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TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS

There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

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Quinoxaline | C8H6N455 | ChemSpider

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A Dual Palladium and Copper Hydride Catalyzed Approach for Alkyl?Aryl Cross-Coupling of Aryl Halides and Olefins

We report an efficient means of sp2?sp3 cross coupling for a variety of terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis. In addition to its applicability to a range of aryl bromide substrates, this process was also suitable for electron-deficient aryl chlorides, furnishing higher yields than the corresponding aryl bromides in these cases. The optimized protocol does not require the use of a glovebox and employs air-stable Cu and Pd complexes as precatalysts. A reaction on 10 mmol scale further highlighted the practical utility of this protocol. Employing a similar protocol, a series of cyclic alkenes were also examined. Cyclopentene was shown to undergo efficient coupling under these conditions. Lastly, deuterium-labeling studies indicate that deuterium scrambling does not take place in this sp2-sp3 cross coupling, implying that beta-hydride elimination is not a significant process in this transformation.

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2, 1448-87-9. In a Article, authors is Tanji, Ken-Ichi£¬once mentioned of 1448-87-9

Microwave-assisted dehydration and chlorination using phosphonium salt

Microwave-assisted reaction using phosphonium salt for dehydration of primary amides and chlorination of hydroxyheteroaromatics was carried out. Copyright Taylor & Francis, Inc.

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Metal- and Acid-Free C-H Formylation of Nitrogen Heterocycles: Using Trioxane as an Aldehyde Equivalent Enabled by an Organic-Soluble Oxidant

A metal-free, innate, and practical C-H formylation of nitrogen heterocycles using trioxane as a formyl equivalent is reported. This reaction provides a mild and robust method for modifying medicinally relevant heterocycles with an aldehyde handle. The use of an organic soluble oxidant, tetrabutylammonium persulfate, is critical in promoting the desired coupling.

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Scope of the suzuki-miyaura cross-coupling reaction of potassium trifluoroboratoketohomoenolates

Potassium trifluoroboratoketohomoenolates were prepared in good yields from either the corresponding alpha,beta-unsaturated compounds or methyl ketones. These organoboron reagents were effectively cross-coupled with various aryl and heteroaryl chlorides.

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Photoredox-Catalysed Decarboxylative Alkylation of N-Heteroarenes with N-(Acyloxy)phthalimides

An iridium photoredox catalyst in combination with either a stoichiometric amount of Br¡ãnsted acid or a catalytic amount of Lewis acid is capable of catalyzing regioselective alkylation of N-heteroarenes with N-(acyloxy)phthalimides at room temperature under irradiation. A broad range of N-heteroarenes can be alkylated using a variety of secondary, tertiary, and quaternary carboxylates. Mechanistic studies suggest that an IrII/IrIIIredox catalytic cycle is responsible for the observed reactivity.

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Green oxidant H2O2 as a hydrogen atom transfer reagent for visible light-mediated Minisci reaction

A visible light-mediated “green” protocol for metal-free oxidative coupling of heteroarenes and aliphatic C-H components has been achieved via a radical pathway. This cross-dehydrogenative coupling method features a broad scope of substrates. The green oxidant H2O2 is used as a hydrogen atom transfer reagent, which is environmentally benign, low cost, and atom economical.

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Synthesis and characterization of linear 1,4-diazine-triphenylamine?based selective chemosensors for recognition of nitroaromatic compounds and aliphatic amines

Novel 1,4-diazine-based dyes of the D?pi?A type, possessing triphenylamine as an electron-donating group, have been developed. Fluorescence studies have demonstrated that emission of these fluorophores is sensitive towards different nitroaromatic compounds and aliphatic amines, both in solutions and in a vapor phase. Moreover, these compounds can be considered as ?naked-eye? fluorescent probes for solution polarity because they possess pronounced solvatochromic properties. Therefore, these compounds have to be regarded as potential multifunctional chemosensors for monitoring hazardous organic substances.

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Synthesis of thieno[2,3-b]quinoxalines from 2-haloquinoxalines

Thieno[2,3-b]quinoxalines were synthesized from 2-haloquinoxalines using palladium catalyst. The coupling of latter with alkynes and addition of one mol equivalent of bromine to the 2-alkynylquinoxalines thus produced was described. The resulting dibromides reacted with dipotassium trithiocarbonate to produce the desired compound.

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O-Alkyl-S-[3-oxo-1,2,4-triazolobenzopyrazin(2)yl-methyl]-(thiono)thiolphosphoric(phosphonic) acid esters

O-Alkyl-S-[3-oxo-1,2,4-triazolobenzopyrazin(2)yl-methyl]-(thiono)thiolphosphoric(phosphonic) acid esters of the formula STR1 in which R is alkyl with 1 to 4 carbon atoms, R1 is alkyl or alkoxy with 1 to 4 carbon atoms, and X is oxygen or sulfur, Which possess insecticidal properties.

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Quinoxaline | C8H6N452 | ChemSpider