Category: 148231-12-3

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 100ml three-necked flask, 5,8-dibromo quinoxaline 1.00g (3.47mmol), 4- (4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine 3 .27g (15.97mmol), tetrakistriphenylphosphinepalladium 0.401g (0.347mmol), as a phase transfer catalyst, adding Aliquat336 (Aldrich) 0.150g (0.371mmol), after argon gas replacement, sequentially added degassed 1,4-dioxane 27ml and 1M- potassium carbonate aqueous solution 22ml with argon gas, after the reflux at 105 15 hours, the reaction solution after returning to room temperature, the chloroform and was added saturated brine . The solution was transferred to a separatory funnel, and the organic layer was washed with saturated brine, after dehydration by stirring at room temperature for 1 hour over magnesium sulfate as a drying agent to the organic layer, then palladium scavenger silica gel (Aldrich the Ltd.) was stirred for 1 hour at 2g was added at room temperature to remove residual palladium in the organic layer. After filtering off the drying agent and silica gel, and the solvent was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (toluene / acetone = 1/2) to obtain a desired product. The yield 0.78g, 79% yield., 148231-12-3

The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RICOH COMPANY LIMITED; HIRANO, SHIGENOBU; OKADA, TAKASHI; SAGISAKA, TOSHIYA; SATO, TSUTOMU; (22 pag.)JP5811808; (2015); B2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen atmosphere, the compound of formula (F) (1.34 g, 7.26 mmol) 5,8-dibromoquinoxanline (0.951 g, 3.30 mmol), sodium tert-butoxide (0.952 g, 9.90 mmol), Bis (dibenzylideneacetone) palladium (0) (0.114 g), (¡À) -2,2 ‘- (¡À) -2,2′-bis (diphenylphosphino ) -1,1′-binaphthalene [(¡À) -2,2′-Bis (diphenylphosphino) -1,1’-binaphthalene] (0.185 g, 0.297 mmol) was refluxed for 12 hours. After the temperature was lowered to room temperature, the mixture was washed with water, the residue was removed with MgSO 4, hydrazine monohydrate was added thereto, and the mixture was stirred at room temperature for 30 minutes. Precipitated in hexane, filtered off the solid and dried under vacuum to obtain the compound P-1.

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Chem, Ltd.; Kim Jin-seok; Bae Jae-sun; Lee Jae-cheol; Shin Hyeon-a; Hwang Min-ho; Ryu So-yeong; Jeong Se-jin; (36 pag.)KR2019/5591; (2019); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 C. Then, the respective terminal arylacetylene (4aeg) (2.5 mmol) dissolved in tetrahydrofuran (10 mL) was added dropwise. The reaction mixture was stirred under reflux for 20min under a nitrogen atmosphere. Cooled down to room temperature, the solution was evaporated, and the crude product was purified by a silica gel chromatography column using hexane/dichloromethane (70:30) as the eluent to afford the respective final compound 5a-g. 5.3.1. 5,8-Bis[(4-methoxyphenyl)ethynyl]quinoxaline: compound 5a Yield: 74 mg (55%). IR (KBr): 2956, 2919, 2850, 2210, 1602, 1565, 1507, 1464, 1248, 826 cm 1.1H NMR (400 MHz, CDCl3) d ppm: 9.00 (s, 2 H), 7.97 (s, 2 H), 7.64 (d, J ? 8.0 Hz, AreH, 4 H), 6.93 (d, J ? 8.0 Hz, AreH, 4 H), 3.85 (s, -OCH3, 6 H). 13C NMR (100 MHz, CDCl3) d ppm: 160.1, 145.4, 143.1, 133.6, 133.4, 123.9, 115.0, 114.0, 97.8, 85.1, 55.3. APPI-MS m/z: Molecular formula C26H18N2O2 requires [MthH]th 391.1441; found: 391.1443., 148231-12-3

The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 148231-12-3

As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the 5,8- […][…] soluble in toluene solvent, and by adding 4 – (diphenyl amino) phenyl boronic acid (1.1 equivalent). The K2CO3 (4.4 equiv) dissolved in distilled water in and added to the mixed solution. By adding tetrahydrofuran solvent, and by adding palladium (0.05 equiv). The mixture at 80 C and the temperature of the refluxing under stirring. After the reaction is finished, by ethyl acetate extraction mixture. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of methylene chloride and hexane to carry out wet refining column chromatography, thereby obtaining compound “m”. (Yield: 43%), 148231-12-3

148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the use of a compound “d” (0.3mol), 5,8-di bromo-Oxoquinoxaline (0.15mol), Pd (OAc)2(6.11mmol), P(t-Bu)3(50 wt %, 15 . 28mmol) sodium and tertiary butyl alcohol (0.61mol) is added to the toluene solvent and stirring. In the solution 120 C and the temperature of the refluxing under stirring 12 hours. After the completion of reaction, the solution is cooled to the room temperature and water and ethyl acetate extraction. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, so as to obtain compound 22. (Yield: 79%), 148231-12-3

As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

A mixture of 3,5-dimethoxyphenylboronic acid (Step 1.8) (3.38 g, 18.6 mmol) in EtOH (15 ml.) was added dropwise to a mixture of 5,8-dibromo-quinoxaline (Step 1.5) (10.7 g, 37.1 mmol, 2 equiv), PdCI2(dppf) (530 mg, 0.7 mmol, 0.03 equiv), Na2CO3 (2 M solution in H2O, 37 ml_, 74.3 mmol, 4 equiv) in toluene (100 ml.) at 1050C, under an argon atmosphere. The reaction mixture was stirred at 105 0C for 2 h, allowed to cool to rt, diluted with EtOAc and H2O, filtered through a pad of celite and extracted with EtOAc. The organic phase was washed with H2O and brine, dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by trituration in DCM, followed by silica gel column chromatography (Hex/EtOAc, 4:1 ) to afford 4.54 g of the title compound as a yellow solid: ES-MS: 345.0 [M+H]+; tR= 5.13 min (System 1 ); Rf = 0.17 (Hex/EtOAc, 4:1 ).

148231-12-3, As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2009/141386; (2009); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider