Category: 15804-19-0

Electric Literature of 15804-19-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a Article£¬once mentioned of 15804-19-0

Benzimidazoles and related heterocycles : 8. Acid-catalyzed rearrangement of 3-aryl-1?H-spiro[2-pyrazoline-5,2?-quinoxalin]- 3?(4?H)-ones as a new efficient method for the synthesis of 2-(pyrazol-3-yl)benzimidazoles

3-Aryl-1?H-spiro[2-pyrazoline-5,2?-quinoxalin] -3?(4?H)-ones, easily available by the reaction of 3-(2-aryl-2-oxoethylidene)-3,4-dihydroquinoxalin-2(1H)-ones with hydrazine hydrate (and phenylhydrazine), in boiling acetic acid undergo new acid-catalyzed rearrangement with the contraction of pyrazine ring of the quinoxaline system to form 2-(pyrazol-3-yl)benzimidazoles. Possible mechanisms of this rearrangement are considered.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N359 | ChemSpider

Reference of 15804-19-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a article£¬once mentioned of 15804-19-0

Synthesis and Characterization of some Novel Quinoxaline-2,3-Dione Derivatives: A Preliminary Investigation on their Activity Against a Human Epithelial Carcinoma Cell Line

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid, was reacted with chlorosulphonic acid under cold condition followed by a reaction with various benzimidazoles to give 2, 3- dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl benzimidazoles in satisfactory yield. Their structures were confirmed using 1H NMR, IR and mass analysis. Cytotoxicity of these derivatives were evaluated by growth inhibition of HEp-2 cells in vitro. The preliminary bioassay indicated that these compounds showed moderate cytotoxicity

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 15804-19-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N392 | ChemSpider

Related Products of 15804-19-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a Article£¬once mentioned of 15804-19-0

Design, synthesis, biological evaluation and molecular docking study on peptidomimetic analogues of XK469

XK469 is identified as a potent quinoxaline antineoplastic agent based on its significant clinical efficacy. It probably exerts its activity via DNA topoisomerase II (topo II) inhibition. To obtain more effective antineoplastic agents, a spectrum of peptidomimetic-type quinoxaline analogues of XK469 was herein designed, synthesized, and evaluated. Few compounds (e.g. 13a and 13b) exhibited obvious cytotoxicity indicated by in?vitro anti-proliferative assay. SAR investigation revealed that introducing of hydrophobic tert-butylamine or dodecylamine moiety at the 3-position of quinoxaline core is favorable for achieving a better anti-proliferative potency, while peptidomimetic derivatives only yielded moderate cytotoxicity. Compounds with improved anti-proliferative activities also demonstrated decent anti-metastatic potencies comparable with that of doxorubicin (Doxo) based on in?vivo mouse model study. The topo II-mediated kinetoplast DNA (kDNA) decatenation assay as well as molecular docking studies implicated that these compounds tend to be potent topo II inhibitors. Overall, compounds 13a and 13b, 13b in particular, standed out from various assessments and might be promising candidates for further chemical optimization.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 15804-19-0. In my other articles, you can also check out more blogs about 15804-19-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N415 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 15804-19-0, name is Quinoxaline-2,3(1H,4H)-dione, introducing its new discovery. HPLC of Formula: C8H6N2O2

Synthesis and antiallergy activity of 2-aryl-5-aroylmethylimidazo [1,2-a]quinoxalin-4-one

Quinoxaline-2,3-diones 1 have been alkylated with phenacyl bromides 2 using K2CO3 acetone and PTC to give 1,4-bis(aroylmethyl) quinoxaline-2,3-diones 3,4 which when refluxed in acetic acid containing ammonium acetate yield the imidazo 1,2-aquinoxalines 5,6. Antiallergy activity of these compounds is discussed.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 15804-19-0, and how the biochemistry of the body works.HPLC of Formula: C8H6N2O2

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N328 | ChemSpider

Synthetic Route of 15804-19-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2. In a Article£¬once mentioned of 15804-19-0

First use of 1,4-dihydro-2,3-quinoxalinedione in the chemistry of coordination polymers: A 3D copper(II) complex containing the 2,3-dioxyquinoxalinate(-2) ligand in a novel coordination mode

The reaction of 1,4-dihydro-2,3-quinoxalinedione (H2L?) with CuCl2 in the presence of LiOH in DMF has led to the 3D coordination polymer [Cu3L2Cl2(DMF)4]n (1) with an (82 ¡¤ 10)-a, lig (LiGe), topology, where L2- is 2,3-dioxyquinoxalinate(-2). This compound is the first coordination polymer of any transition metal featuring L2- and contains the ligand in a novel 3.1111 (Harris notation) coordination mode. IR data are discussed in terms of the chemical composition of the polymer and the coordination mode of L2-. Variable-temperature (2-300 K) magnetic susceptibility and variable-field (0-5 T) magnetization studies reveal that L2- propagates weak antiferromagnetic exchange interactions through its “quinoxaline” moiety.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N339 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C8H6N2O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2

Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors

The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: 1 which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N276 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Quinoxaline-2,3(1H,4H)-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2

Synthesis of 1-(3-phenylpropyl)-4-(pyridinylmethoxy)-[1,2,4]triazolo[4,3-a] quinoxalines

Starting from 2,3-dichloroquinoxaline, a synthetic strategy for the preparation of 1-(3-phenylpropyl)-4-(pyridinylmethoxy)[1,2,4]triazolo[4,3-a]quinoxalines is described.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Quinoxaline-2,3(1H,4H)-dione, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 15804-19-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N400 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: Quinoxaline-2,3(1H,4H)-dione, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 15804-19-0, name is Quinoxaline-2,3(1H,4H)-dione. In an article£¬Which mentioned a new discovery about 15804-19-0

1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents

A series of new 1,4-dihydro-1,2,4-triazolo[4,3-a]quinoxaline-1,4-diones has been reported. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated rat passive cutaneous anaphylaxis (PCA). Most of this new class of antiallergic agents showed good activity in the RMC and PCA tests. The most potent compound, 2-acetyl-7-chloro-5-n-propyl-1,2,4-triazolo[4,3-a]quinoxaline-1,4-dione, with an I50 value of 0.1 muM, is 30 times more potent than disodium cromoglycate (DSCG) in the RMC assay.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N354 | ChemSpider

Application of 15804-19-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 15804-19-0, molcular formula is C8H6N2O2, introducing its new discovery.

17O NMR studies of electronic and steric interactions of substituted quinoxaline-2(1H),3(4H)-diones

17O nmr studies, at natural abundance, of substituted quinoxaline-2(1H),3(4H)-diones demonstrate that the 17O chemical shift data can provide new insights into steric and electronic interactions due to long range substituent effects on the aromatic ring. The role of considerable “keto” character and torsion angle deformation of the diamide group in solution is emphasized.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 15804-19-0 is helpful to your research. Application of 15804-19-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N327 | ChemSpider

Electric Literature of 15804-19-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 15804-19-0, molcular formula is C8H6N2O2, introducing its new discovery.

Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis

An oxidant, base and metal free methodology has been developed for the synthesis of various 2-substituted and non-substituted benzazoles, quinazolines and quinazolinones using oxalic/malonic acids as an in situ carbon source. This methodology is applicable for a wide range of substituted o-phenylenediamine, o-aminothiophenol, o-aminophenol and o-aminobenzamide containing various functional groups and provides good to excellent yields of the corresponding product. Furthermore an easy workup procedure, high yield and easy isolation of products are key features of this methodology. The developed protocol is also applicable for the gram scale synthesis of benzimidazoles.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 15804-19-0 is helpful to your research. Electric Literature of 15804-19-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N395 | ChemSpider