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The reaction of 6-chloro-2-(1-methylhydrazino)quinoxaline 4-oxide 1 or 6-chloro-2-(1-methylhydrazino)quinoxaline 5 with phenyl isothiocyanate under reflux in N,N-dimethylformamide gave 7-chloro-3-methyl-1,2,4-triazolo<4,3-a>quinoxalin-3-ium-1-thioate 4, which was also obtained by refluxing of 6-chloro-2-<1-methyl-2-(N-phenylthiocarbamoyl)hydrazino>quinoxaline 4-oxide 2b or 6-chloro-2-<1-methyl-2-(N-phenylthiocarbamoyl)hydrazino>quinoxaline 6 in N,N-dimethylformamide.

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Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL- 13

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The invention discloses thick mixed oxygen radical phenoxy carboxylic acid derivatives and their herbicidal activity, the chemical structural formula shown in formula I: In the formula, R1 , R2 , R3 , R4 , R5 , R6 C is hydrogen or1 – C3 C alkyl or1 – C3 Halogenated alkyl in any one of; X is – N=CH – or oxygen; Y is nitrogen or oxygen; X1 For hydrogen either fluorine or chlorine either bromine or iodine or trifluoromethyl or cyano or nitro in any one of the. The invention also relates to a composition containing the above-mentioned compound and thick mixed oxygen radical phenoxy carboxylic acid derivatives in agricultural herbicide application, some compounds have herbicidal activity of very high, in the amount of 5 g/mu can be obtained under a very good control effect. (by machine translation)

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Compounds that interact with the histamine H4 receptor, and which may be useful for treating or preventing disorders and conditions mediated by the histamine H4 receptor, e.g. inflammation, are of formula (I) wherein Q is CR1 or N; X is CR2 or N, provided that Q and X are not both N; Y is CR3 or N; Z is CH or N; R1, R2, R3, R4, R5 and R6 are independently H, F, Cl, Br, I, or a hydrocarbon group which optionally contains one or more heteroatoms; and R7 is a heterocyclic radical including one or more N atoms; or a pharmaceutically acceptable salt, ester or solvate thereof.

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Facile regioselective synthesis of 2,6-dichloroquinoxaline and 2-chloro-6-iodoquinoxaline is described.Electrophilic substitution reaction of 2(1H)-quinoxalinone with chloride and iodide ion in 95percent sulfuric acid occurred at 6-position exclusively.

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Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.

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This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.

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The invention relates to a synthesis method of spore, characterized in that the first hydroquinone with sodium hydroxide to prepare the sodium salt of hydroquinone, with 2, 6 – dichloro quinozaline reaction, to obtain 4 – (6 – chloro – 2 kuikui oh linlin oxygen radical) phenol, then with paratoluene sulfonic acid ethyl lactate reaction to obtain the spore. The synthesizing process to optimize the original process, advantage lies in the organic solvent in the reaction and post-processing, the system reduces the response of the alkaline, avoids the strong alkaline aqueous phase reactions the drawback of easy to produce impurities, reduces the raw material 2, 6 – dichloro quinozaline hydrolysis, so that the 4 – (6 – chloro – 2 kuikui oh linlin oxygen radical) to the phenol content of 98% or more, the yield of 92% or more, follow-up synthesis reaction the yield of 90% or more. (by machine translation)

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The isoxazolo<2,3-a>quinoxalines 11a,b and pyrrolo<1,2-a>quinoxalines 12a,b were selectively synthesized from the 2-substituted 6-chloroquinoxaline 4-oxides 10a,b.The pyrrolo<1,2-a>quinoxalines 12a,b were clarified to be produced by the ring transformation of the isoxazolo<2,3-a>quinoxalines 11a,b.

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The present invention relates to a method for producing quizalofop-P-ethyl environment-friendly process, characterized in that the first hydroquinone with sodium hydroxide reaction to prepare the sodium salt of hydroquinone, with 2, 6 – dichloro quinozaline reaction, to obtain 4 – (6 – chloro – 2 kuikui oh linlin oxygen radical) phenol, then with paratoluene sulfonic acid ethyl lactate reaction to obtain the quizalofop-P-ethyl, herbicide then the grease of the alkaline hydrolysis, acidification, recovery 6 – chloro – 2 – hydroxy-quinoxaline. The synthesis process is advantageous in that the organic solvent in the reaction and post-processing, the system reduces the response of the alkaline, avoids the strong alkaline aqueous phase reactions the drawback of easy to produce impurities, reduces the raw material 2, 6 – dichloro quinozaline hydrolysis, so that the 4 – (6 – chloro – 2 kuikui oh linlin oxygen radical) to the phenol content of 98% or more, the yield of 92% or more, the recovery of the herbicide of the grease in the 6 – chloro – 2 – hydroxy-quinoxaline, not only reduces the discharge capacity of the solid waste, the protection of the environment, reduces the quizalofop-P-ethyl intermediate cost. (by machine translation)

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