Category: 1910-90-3

Wang, Han et al. published their research in Molecules in 2012 | CAS: 1910-90-3

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.COA of Formula: C8H5BrN2O2

Large-scale solvent-free chlorination of hydroxy-pyrimidines, -pyridines, -pyrazines and -amides using equimolar POCl3 was written by Wang, Han;Wen, Kun;Wang, Le;Xiang, Ye;Xu, Xiaocheng;Shen, Yongjia;Sun, Zhihua. And the article was included in Molecules in 2012.COA of Formula: C8H5BrN2O2 This article mentions the following:

Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxypyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3COA of Formula: C8H5BrN2O2).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.COA of Formula: C8H5BrN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Dhameliya, Tejas M. et al. published their research in Journal of Organic Chemistry in 2017 | CAS: 1910-90-3

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson閳ユ獨, and Alzheimer閳ユ獨 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application of 1910-90-3

Rationalization of Benzazole-2-carboxylate versus Benzazine-3-one/Benzazine-2,3-dione Selectivity Switch during Cyclocondensation of 2-Aminothiophenols/Phenols/Anilines with 1,2-Biselectrophiles in Aqueous Medium was written by Dhameliya, Tejas M.;Chourasiya, Sumit S.;Mishra, Eshan;Jadhavar, Pradeep S.;Bharatam, Prasad V.;Chakraborti, Asit K.. And the article was included in Journal of Organic Chemistry in 2017.Application of 1910-90-3 This article mentions the following:

The cyclocondensation reaction of 2-aminothiophenols with 1,2-biselectrophiles such as Et glyoxalate and di-Et oxalate in aqueous medium leads to the formation of benzothiazole-2-carboxylates via the 5-endo-trig process contrary to Baldwin’s rule. The reaction of 2-aminophenols/anilines produced the corresponding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Baldwin’s rule. The mechanistic insights of these cyclocondensation reactions using the hard-soft acid-base principle, quantum chem. calculations (d. functional theory), and orbital interaction studies rationalize the selectivity switch of benzothiazole-2-carboxylates vs. benzazine-3-ones/benzazine-2,3-diones. The presence of water facilitates these cyclocondensation reactions by lowering of the energy barrier. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3Application of 1910-90-3).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson閳ユ獨, and Alzheimer閳ユ獨 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application of 1910-90-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Hatakeyama-Sato, Kan et al. published their research in Batteries & Supercaps in 2022 | CAS: 1910-90-3

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.SDS of cas: 1910-90-3

Quadruply Fused Aromatic Heterocycles toward 4 V-Class Robust Organic Cathode-Active Materials was written by Hatakeyama-Sato, Kan;Go, Choitsu;Akahane, Tomoki;Kaseyama, Takahiro;Yoshimoto, Takuji;Oyaizu, Kenichi. And the article was included in Batteries & Supercaps in 2022.SDS of cas: 1910-90-3 This article mentions the following:

Quadruply fused aromatic heterocycles are examined as 4 V-class organic cathode-active materials. A newly synthesized dimethylfluoflavin-substituted polymer displays reversible charge/discharge at high potentials of 3.5 and 4.1 V (vs. Li/Li+) as a cathode-active material for organic secondary batteries. The robust redox-active heterocycles enable the long cycle-life (>1000) while maintaining the high potential over 4 V. The linear polymer backbone and radical spin configuration in the heterocycles are the keys to enhancing the voltages and the cycle life. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3SDS of cas: 1910-90-3).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.SDS of cas: 1910-90-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Good, Andrew C. et al. published their research in Journal of Medicinal Chemistry in 2012 | CAS: 1910-90-3

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Application In Synthesis of 6-Bromoquinoxaline-2,3(1H,4H)-dione

Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design was written by Good, Andrew C.;Liu, Jinyu;Hirth, Bradford;Asmussen, Gary;Xiang, Yibin;Biemann, Hans-Peter;Bishop, Kimberly A.;Fremgen, Trisha;Fitzgerald, Maria;Gladysheva, Tatiana;Jain, Annuradha;Jancsics, Katherine;Metz, Markus;Papoulis, Andrew;Skerlj, Renato;Stepp, J. David;Wei, Ronnie R.. And the article was included in Journal of Medicinal Chemistry in 2012.Application In Synthesis of 6-Bromoquinoxaline-2,3(1H,4H)-dione This article mentions the following:

We have studied the subtleties of fragment docking and binding using data generated in a Pim-1 kinase inhibitor program. Crystallog. and docking data analyses have been undertaken using inhibitor complexes derived from an inhouse surface plasmon resonance (SPR) fragment screen, a virtual needle screen, and a de novo designed fragment inhibitor hybrid. These investigations highlight that fragments that do not fill their binding pocket can exhibit promiscuous hydrophobic interactions due to the lack of steric constraints imposed on them by the boundaries of said pocket. As a result, docking modes that disagree with an observed crystal structure but maintain key crystallog. observed hydrogen bonds still have potential value in ligand design and optimization. This observation runs counter to the lore in fragment-based drug design that all fragment elaboration must be based on the parent crystal structure alone. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3Application In Synthesis of 6-Bromoquinoxaline-2,3(1H,4H)-dione).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Application In Synthesis of 6-Bromoquinoxaline-2,3(1H,4H)-dione

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

09/29/21 News More research is needed about 1910-90-3

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1910-90-3 is helpful to your research. 1910-90-3

New Advances in Chemical Research, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 1910-90-3, In a article, mentioned the application of 1910-90-3, Name is 6-Bromoquinoxaline-2,3(1H,4H)-dione, molecular formula is C8H5BrN2O2

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a?n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a?3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i?3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1910-90-3 is helpful to your research. 1910-90-3

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1945 | ChemSpider

 

Sep 2021 News Top Picks: new discover of 1910-90-3

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1910-90-3, and how the biochemistry of the body works.Reference of 1910-90-3

Reference of 1910-90-3, New research progress on 1910-90-3 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.1910-90-3, Name is 6-Bromoquinoxaline-2,3(1H,4H)-dione, molecular formula is C8H5BrN2O2. In a article，once mentioned of 1910-90-3

Heterocyclic dihydroxyquinoxaline compounds having the formula STR1 wherein R 1 is halogen, CN, CF 3, ethynyl, or N 3 andR 2 is SO 2 C 1-3 -alkyl, CF 3, NO 2, ethynyl, or CN.The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters, particularly the quisqualate receptors, and especially as neuroleptics.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1910-90-3, and how the biochemistry of the body works.Reference of 1910-90-3

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1944 | ChemSpider

 

More research is needed about 6-Bromoquinoxaline-2,3(1H,4H)-dione

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1910-90-3, and how the biochemistry of the body works.Synthetic Route of 1910-90-3

Synthetic Route of 1910-90-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1910-90-3, Name is 6-Bromoquinoxaline-2,3(1H,4H)-dione,introducing its new discovery.

6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics

Heterocyclic dihydroxyquinoxaline compounds having the formula STR1 wherein R 1 is halogen, CN, CF 3, ethynyl, or N 3 andR 2 is SO 2 C 1-3 -alkyl, CF 3, NO 2, ethynyl, or CN.The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters, particularly the quisqualate receptors, and especially as neuroleptics.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1910-90-3, and how the biochemistry of the body works.Synthetic Route of 1910-90-3

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1944 | ChemSpider

Simple exploration of 1910-90-3

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1910-90-3 is helpful to your research. 1910-90-3

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 1910-90-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1910-90-3, name is 6-Bromoquinoxaline-2,3(1H,4H)-dione. In an article£¬Which mentioned a new discovery about 1910-90-3

A One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a?n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a?3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i?3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1910-90-3 is helpful to your research. 1910-90-3

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1945 | ChemSpider

Simple exploration of 1910-90-3

1910-90-3, The synthetic route of 1910-90-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1910-90-3,6-Bromoquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 1 6-Bromo-2,3-dihydroxy-7-nitroquinoxaline To a solution of 0.5 g (2.1 mmol) of 6-bromo-2,3-dihydroxy quinoxaline in 5 ml of concentrated sulfuric acid is added at 0 C. 210 mg (2.1 mmol) KNO3. The solution is stirred at 0 C. for 30 min. and at 24 C. for 3 h. The reaction mixture is poured into ice-water giving 5 g precipitate. The crude product is dissolved in 30 ml of hot 2N NaOH. 4N HCl is added ajusting pH to 2 giving 0.4 g (67%) of 6-bromo-2,3-dihydroxy-7-nitro-quinoxaline, m.p. >300 C. NMR: two singlets (ppm 7.3 and 7.7 downfield from TMS).

1910-90-3, The synthetic route of 1910-90-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; A/S Ferrosan; US4812458; (1989); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider