Category: 19777-66-3

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Modified amino acids and peptides. Part 2. A convenient conversion of amino and peptide alcohols into amines, published in 1992-12-31, which mentions a compound: 19777-66-3, Name is (S)-Propane-1,2-diamine dihydrochloride, Molecular C3H12Cl2N2, Electric Literature of C3H12Cl2N2.

A convenient general method for the conversion of N-protected amino and peptide alcs. RNHCHR1CH2R2 (I; R = Z, Boc, Z-Ala, R1 = H, PhCH2, Me, CH2CHMe2, R2 = OH; Z = PhCH2O2C, Boc = Me3CO2C) into amines I (R2 = NH2, NEt2) is described. Thus, treatment of I (R = OH) with MeSO2Cl gave the corresponding mesylates, which underwent substitution with HNEt2 to give I (R2 = NEt2) or NaN3 to give the corresponding azides I (R2 = N3). Hydrogenation of I (R2 = N3) gave the corresponding monoprotected diamines I (R = Boc, R2 = NH2) or free diamines I (R = H, R2 = NH2), depending on the protecting group. Selective reduction of the azido group in I (R = Z, R2 = N3) was performed in high yield using NaBH4 in the presence of 10% Pd/C to give I (R = Z, R2 = NH2).

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Repta, A. J.; Baltezor, M. J.; Bansal, P. C. researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).SDS of cas: 19777-66-3.They published the article 《Utilization of an enantiomer as a solution to a pharmaceutical problem: application to solubilization of 1,2-bis(4-piperazine-2,6-dione)propane》 about this compound( cas:19777-66-3 ) in Journal of Pharmaceutical Sciences. Keywords: ICRF 159 solubilization enantiomer; piperazinedionepropane solubilization enantiomer. We’ll tell you more about this compound (cas:19777-66-3).

An enantiomer (R)(-)-I [24613-06-7] of the cytotoxic agent (±)-1,2-bis(4-piperazine-2,6-dione)propane [(±)-I] (ICRF 159) [21416-67-1] was utilized to overcome a solubility problem in the preparation of a solution suitable for i.v. use. The enantiomers (S)(+)-I [24584-09-6] and (R)(-)-I were prepared and were about five times more soluble and melted at about 40° lower than the racemic compound This study appears to be the 1st reported instance in which the difference in the phys. properties of a racemic compound and its enantiomers was utilized to improve a pharmaceutical formulation. The expected differences in the phys. properties of racemic solids and their corresponding enantiomers are discussed briefly in relation to the 3 racemic modifications known to exist.

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Oshita, Hiromi; Suzuki, Takashi; Kawashima, Kyohei; Abe, Hitoshi; Tani, Fumito; Mori, Seiji; Yajima, Tatsuo; Shimazaki, Yuichi published the article 《π-π Stacking interaction in an oxidized CuII-Salen complex with a side-chain indole ring: An approach to the function of the tryptophan in the active site of galactose oxidase》. Keywords: galactose oxidase active site mimic copper salen complex tryptophan; copper; heterocycles; oxidation; pi interactions; radicals.They researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Formula: C3H12Cl2N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:19777-66-3) here.

In order to gain new insights into the effect of the π-π stacking interaction of the indole ring with the CuII-phenoxyl radical as seen in the active form of galactose oxidase, we have prepared a CuII complex of a methoxy-substituted salen-type ligand, containing a pendent indole ring on the dinitrogen chelate backbone, and characterized its one-electron-oxidized forms. The X-ray crystal structures of the oxidized CuII complex exhibited the π-π stacking interaction of the indole ring mainly with one of the two phenolate moieties. The phenolate moiety in close contact with the indole moiety showed the characteristic phenoxyl radical structural features, indicating that the indole ring favors the π-π stacking interaction with the phenoxyl radical. The UV/Vis/NIR spectra of the oxidized CuII complex with the pendent indole ring was significantly different from those of the complex without the side-chain indole ring, and the absorption and CD spectra exhibited a solvent dependence, which is in line with the phenoxyl radical-indole stacking interaction in solution The other physicochem. results and theor. calculations strongly support that the indole ring, as an electron donor, stabilizes the phenoxyl radical by the π-π stacking interaction.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about From Mesocates to Helicates: Structural, Magnetic and Chiro-Optical Studies on Nickel(II) Supramolecular Assemblies Derived from Tetradentate Schiff Bases.Electric Literature of C3H12Cl2N2.

The systematic reactions of a family of tetradentate pyridyl/imine and quinolyl/imine racemic or enantiopure Schiff bases with Ni(NO3)2 or Ni(ClO4)2 in the presence of sodium azide yielded, as a function of the starting racemic, chiral or achiral base, a set of chiral, meso or achiral complexes. In all cases, the compounds consist of two NiII cations linked by a double azido bridge in its end-on coordination mode. All the dimers exhibit a mesocate supramol. structure and one of them, the unprecedented mix of helicate and mesocate in 2:1 ratio. The transition from mesocate to helicate conformation was reached by tuning the flexibility of the central spacers of the Schiff bases and the size of the substituents. Electronic CD (ECD) studies were performed for two pairs of enantiomers and interpreted by DFT calculations Susceptibility measurements show a ferromagnetic coupling between the NiII cations mediated by the end-on azido bridges.

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SDS of cas: 19777-66-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists. Author is Ameriks, Michael K.; Ao, Hong; Carruthers, Nicholas I.; Lord, Brian; Ravula, Suchitra; Rech, Jason C.; Savall, Brad M.; Wall, Jessica L.; Wang, Qi; Bhattacharya, Anindya; Letavic, Michael A..

The synthesis, SAR, and preclin. characterization of a series of substituted 6,7-dihydro[1,2,4]triazolo[4,3]pyrazin-8(5H)-one P2X7 receptor antagonists are described. Optimized leads from this series comprise some of the most potent human P2X7R antagonists reported to date (IC50s < 1 nM). They also exhibit sufficient potency and oral bioavailability in rat to enable extensive in vivo profiling. Although many of the disclosed compounds are peripherally restricted, compound I is brain penetrant and upon oral administration demonstrated dose-dependent target engagement in rat hippocampus as determined by ex vivo receptor occupancy with radiotracer II (ED50 = 0.8 mg/kg). There are many compounds similar to this compound(19777-66-3)SDS of cas: 19777-66-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Kobayashi, Yuki; Obayashi, Riho; Watanabe, Yuki; Miyazaki, Hiroki; Miyata, Issei; Suzuki, Yuta; Yoshida, Yukihiro; Shioiri, Takayuki; Matsugi, Masato published the article 《Unprecedented Asymmetric Epoxidation of Isolated Carbon-Carbon Double Bonds by a Chiral Fluorous Fe(III) Salen Complex: Exploiting Fluorophilic Effect for Catalyst Design》. Keywords: fluorous salen iron chloride complex preparation; vinylbenzene salen iron chloride complex enantioselective epoxidation; phenyl oxirane preparation.They researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Electric Literature of C3H12Cl2N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:19777-66-3) here.

The first asym. epoxidation of isolated carbon-carbon double bonds by a chiral salen complex using ubiquitous Fe(III) as a center-metal was described. By simultaneously introducing fluorous tags and tert-Bu groups into the ligand of the salen complex, asym. epoxidation was achieved. The fluorous tags act as both the electron-withdrawing groups, to improve the catalytic activity for oxidation, and the driving force to form a unique asym. stereo environment. Crystallog. anal. of the complex revealed that the catalyst has a distinctive umbrella structure based on intramol. fluorophilic effect. This is the first example of asym. catalytic space construction that exploits fluorous space-interaction of neighboring fluorous tags.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ) is researched.COA of Formula: C3H12Cl2N2.Park, Jae-Hoon; Ha, Hyun-Joon; Lee, Won Koo; Genereux-Vincent, Tobie; Kazlauskas, Romas J. published the article 《Molecular Basis for the Stereoselective Ammonolysis of N-Alkyl Aziridine-2-Carboxylates Catalyzed by Candida antarctica Lipase B》 about this compound( cas:19777-66-3 ) in ChemBioChem. Keywords: mol modeling stereoselective ammonolysis aziridinecarboxylate catalyst Candida antarctica lipase. Let’s learn more about this compound (cas:19777-66-3).

Candida antarctica lipase B was used to catalyzed a stereoselective ammonolysis of N-(alkyl)aziridine-2-carboxylates in tert-butanol with ammonia and yielded (2S)-2-aziridinecarboxamide and remaining (2R)-2-aziridinecarboxylic acid ester. Varying the N-1 substituent on the aziridine ring changed the rate and stereoselectivity of the reaction. Substrates with a benzyl substituent or a (1R)-1-phenylethyl substituent reacted approx. ten times faster than substrates with a (1S)-1-phenylethyl substituent. Substrates with a benzyl substituent showed little stereoselectivity (E = 5-7) while substrates with either a (1R)-1-phenylethyl or (1S)-1-phenylethyl substituent showed high stereoselectivity (D > 50). Mol. modeling by using the current paradigm for enantioselectivity-binding of the slow enantiomer by an exchange-of-substituents orientation-could not account for the exptl. results. However, modeling an umbrella-like-inversion orientation for the slow enantiomer could account for the exptl. results. Steric hindrance between a Me group in the (1S)-1-phenylethyl substituent and Thr138 and Ile189 in the acyl-binding site likely accounts for the slow reaction. Enantioselectivity likely stems from an unfavorable interaction of the methine hydrogen with Thr40 for the slow enantiomer and from subtle differences in the orientations of the other three substituents. This success in rationalizing the enantioselectivity supports the notion that an umbrella-like-inversion orientation can contribute to enantioselectivity in lipases.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yoshida, Yusuke; Inoue, Katsuya; Kurmoo, Mohamedally researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Electric Literature of C3H12Cl2N2.They published the article 《On the Nature of the Reversibility of Hydration-Dehydration on the Crystal Structure and Magnetism of the Ferrimagnet [MnII(enH)(H2O)][CrIII(CN)6]·H2O》 about this compound( cas:19777-66-3 ) in Inorganic Chemistry. Keywords: manganese chromium complex hydration dehydration crystal structure magnetism. We’ll tell you more about this compound (cas:19777-66-3).

The authors report the synthesis, crystal structure, and thermal and magnetic properties of the two-dimensional achiral soft ferrimagnet [MnII(enH)(H2O)][CrIII(CN)6]·H2O (1), en = 1,2-diaminoethane, as well as the recyclability of the dehydration and rehydration and their influence on the crystal structure and its magnetic properties. Unlike [Mn(S-pnH)(H2O)][Cr(CN)6]·H2O (2S, pn = 1,2-diaminopropane), which is a chiral (P212121) enantiopure ferrimagnet (TC = 38 K), 1 crystallizes in the achiral orthorhombic Pcmn space group, having a similar two-dimensional square network of Mn-Cr with bridging cyanide, and 1 behaves also as a soft ferrimagnet (TC = 42 K). X-ray diffraction experiments on a single crystal of 1 indicate a transformation from a single crystal to an amorphous phase upon dehydration and partial recovery of its crystallinity upon rehydration. The dehydrated phase 1-DP exhibits long-range ordering at 75 K to a ferrimagnetic state and coercive field at 2 K of 100 Oe, which are a higher critical temperature and coercive field than for the virgin sample (HC = 60 Oe). Thermogravimetric analyses indicate that the crystallinity deteriorates upon hydration-dehydration cycling, with persistence toward the amorphous phase, as also seen by magnetization measurements. This effect is associated with an increase of statistical disorder inherent in the dehydration-rehydration process. X-ray powder diffraction suggests that 1-DP may retain order within the layers but loses coherence in the stacking of the layers.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 19777-66-3, is researched, Molecular C3H12Cl2N2, about Effect of composition on the properties of novel optically active methacrylic copolymers containing side-chain zinc-porphyrin chromophores suitable to chiral recognition, the main research direction is methacrylic copolymer synthesis chiral recognition.Application In Synthesis of (S)-Propane-1,2-diamine dihydrochloride.

New chiral methacrylic copolymers, bearing in the side chain one or two L-lactic acid residues linked to a porphyrin moiety, with variable molar content of Me methacrylate co-units, have been prepared by radical copolymerization of the corresponding monomers. The resulting macromols. have been fully characterized both in solution and in the solid state with particular attention to their thermal, UV-Vis and chiroptical properties by comparison with those of the related porphyrin containing homopolymers and monomeric models. The zinc-porphyrin coordination complexes of the above functional derivatives have been studied as macromol. hosts for the chiral recognition of optically active diamine on the basis of the amine/zinc coordination complex exhibiting CD spectra related to the absolute configuration of the diamine guest. The results are discussed in terms of diamine complexation ability by the zinc-porphyrin complex which is related to copolymer composition and, consequently, to backbone flexibility and chromophore mobility.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Propane-1,2-diamine dihydrochloride(SMILESS: C[C@H](N)CN.[H]Cl.[H]Cl,cas:19777-66-3) is researched.Formula: C9H7NO2. The article 《HPLC detection and evaluation of chiral compounds with a laser-based chiroptical detector》 in relation to this compound, is published in LC-GC. Let’s take a look at the latest research on this compound (cas:19777-66-3).

The sensitivity and ruggedness of chiroptical detectors have improved considerably during the past decade. The authors examine >230 chiral compounds using the latest laser-based polarimetry detector for HPLC. They also examine the relation between optical rotation at the detector wavelength of 675 nm and the sodium D line. The authors consider the sensitivity, linear dynamic range, and effect of solvent composition on rotation and its general use as an HPLC detector for chiral compounds

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