Category: 19777-66-3

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Unprecedented Asymmetric Epoxidation of Isolated Carbon-Carbon Double Bonds by a Chiral Fluorous Fe(III) Salen Complex: Exploiting Fluorophilic Effect for Catalyst Design, Author is Kobayashi, Yuki; Obayashi, Riho; Watanabe, Yuki; Miyazaki, Hiroki; Miyata, Issei; Suzuki, Yuta; Yoshida, Yukihiro; Shioiri, Takayuki; Matsugi, Masato, which mentions a compound: 19777-66-3, SMILESS is C[C@H](N)CN.[H]Cl.[H]Cl, Molecular C3H12Cl2N2, Name: (S)-Propane-1,2-diamine dihydrochloride.

The first asym. epoxidation of isolated carbon-carbon double bonds by a chiral salen complex using ubiquitous Fe(III) as a center-metal was described. By simultaneously introducing fluorous tags and tert-Bu groups into the ligand of the salen complex, asym. epoxidation was achieved. The fluorous tags act as both the electron-withdrawing groups, to improve the catalytic activity for oxidation, and the driving force to form a unique asym. stereo environment. Crystallog. anal. of the complex revealed that the catalyst has a distinctive umbrella structure based on intramol. fluorophilic effect. This is the first example of asym. catalytic space construction that exploits fluorous space-interaction of neighboring fluorous tags.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Cold Crystallization of Chiral Schiff-Base Nickel(II) Complex Having Alkyl Chains and a Characteristic Methyl Group.Product Details of 19777-66-3.

Mols. exhibiting cold crystallization, an exothermic phenomenon in heating following supercooling, can be used as a heat storing material. However, examples in nonpolymers are still few. A chiral Schiff-base nickel(II) complex, which had a characteristic Me group and long alkyl chains, exhibited complicated thermal behavior including cold crystallization The Me group was a steric barrier to dimerization and mol. stacking, leading to the supercooled state. The thermal behavior of enantiomer was different from that of racemate.

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Name: (S)-Propane-1,2-diamine dihydrochloride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2.

The enantiomeric purity of reagents used in asym. synthesis is of fundamental importance when evaluating the selectivity of a reaction and the product purity. In this work, 109 chiral reagents (many recently introduced) are assayed. Approx. 64% of these reagents had moderate to high levels of enantiomeric impurities (i.e. from >0.1% to <16%). The type of chiral reagents assayed and used in enantioselective synthesis include metal-ligand catalysts for allylic substitutions, catalysts for addition of Grignard reagents and other additions, epoxidations and reduction of ketones and aldehydes; Ru-complex auxiliaries for asym. cyclopropanation, as well as amine, diamine, alc., diol, amino alc., carboxylic acid and oxazolidinone auxiliaries; epoxide, lactone, furanone, pyrrolidinone, nitrile, sulfoximine and carboxylic acid synthons (including malic acid, mandelic acid, lactic acid and tartaric acid); and a variety of chiral resolving agents. Accurate, efficient assays for all compounds are given. From this literature《Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2》,we know some information about this compound(19777-66-3)Name: (S)-Propane-1,2-diamine dihydrochloride, but this is not all information, there are many literatures related to this compound(19777-66-3).

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Ng, Christina; Sabat, Michal; Fraser, Cassandra L. published the article 《Metal Complexes with Cis α Topology from Stereoselective Quadridentate Ligands with Amine, Pyridine, and Quinoline Donor Groups》. Keywords: crystal structure copper bispentafluorophenylbismethylpyridyldiazahexane chloro; transition metal ethylenediamine propylenediamine quadridentate derivative preparation; diastereomer transition metal quadridentate polyamine preparation; stereoselective quadridentate polyamine metal complex diastereomer; oxidation potential transition metal quadridentate polyamine; topol stereoselective transition metal quadridentate polyamine.They researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Formula: C3H12Cl2N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:19777-66-3) here.

Though the principles governing quadridentate topol. and metal stereochem. were known for some time, the cis α topol. was little exploited in designing catalysts for asym. reactions. Study of the inorganic chem. of labile metal cis α complexes was undertaken as a prelude to exploring their potential to serve as catalysts for a variety of different reactions. The synthesis of 1st row transition metal complexes of quadridentate ligands with ethylenediamine (en) and S-propylenediamine (S-pn) backbones that were alkylated at N with either pyridine (py) or quinoline (qn) donor groups as well as with noncoordinating benzyl (Bn) or pentafluorobenzyl (F5Bn) groups was undertaken. The steric and electronic properties vary throughout the ligand series, en(Bn)py, 1, en(F5Bn)py, 2, S-pn(F5Bn)py, 3, and S-pn(F5Bn)qn, 4. These ligands were reacted with MCln salts (n = 2, M = Mn, Fe, Co, Ni, Cu, Zn; n = 3, M = Fe) to generate, in most cases, octahedral complexes with the targeted cis α topol. UV/visible, NMR, IR, cyclic voltammetry (CV), and conductivity anal. are described for the metal compounds x-ray structural anal. of [Cu{en(F5Bn)py}Cl]Cl reveals a five coordinate square pyramidal geometry. Single or major diastereomers were obtained for all diamagnetic Zn(II) complexes as well as for Co(III) analogs that were prepared by oxidation of Co(II) species using Br2 as the oxidant. Electronic differences among ligands are reflected in the oxidation potentials of the resp. metal complexes as determined by CV, with fluorinated systems showing greater resistance to oxidation, as expected.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 19777-66-3, is researched, SMILESS is C[C@H](N)CN.[H]Cl.[H]Cl, Molecular C3H12Cl2N2Journal, Jingxi Huagong Zhongjianti called Synthesis of dexrazoxane, Author is Yu, Caixia; Yang, Yihong; Zhang, Heng; Yang, Jianshe, the main research direction is dexrazoxane synthesis diaminopropane.Product Details of 19777-66-3.

Dexrazoxane, a cardiac medicine, was synthesized in 35.7% overall yield starting from racemic 1,2-diaminopropane. The resolution of l,2-diaminopropane with D-(-)-tartaric acid followed by reaction with potassium chloride resulted in (S)-1,2-diaminopropane dihydrochloride, which was further converted into the title compound in two steps. The structure was confirmed with 1H NMR and IR.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 19777-66-3, is researched, SMILESS is C[C@H](N)CN.[H]Cl.[H]Cl, Molecular C3H12Cl2N2Journal, Article, Chemistry – A European Journal called π-π Stacking interaction in an oxidized CuII-Salen complex with a side-chain indole ring: An approach to the function of the tryptophan in the active site of galactose oxidase, Author is Oshita, Hiromi; Suzuki, Takashi; Kawashima, Kyohei; Abe, Hitoshi; Tani, Fumito; Mori, Seiji; Yajima, Tatsuo; Shimazaki, Yuichi, the main research direction is galactose oxidase active site mimic copper salen complex tryptophan; copper; heterocycles; oxidation; pi interactions; radicals.Formula: C3H12Cl2N2.

In order to gain new insights into the effect of the π-π stacking interaction of the indole ring with the CuII-phenoxyl radical as seen in the active form of galactose oxidase, we have prepared a CuII complex of a methoxy-substituted salen-type ligand, containing a pendent indole ring on the dinitrogen chelate backbone, and characterized its one-electron-oxidized forms. The X-ray crystal structures of the oxidized CuII complex exhibited the π-π stacking interaction of the indole ring mainly with one of the two phenolate moieties. The phenolate moiety in close contact with the indole moiety showed the characteristic phenoxyl radical structural features, indicating that the indole ring favors the π-π stacking interaction with the phenoxyl radical. The UV/Vis/NIR spectra of the oxidized CuII complex with the pendent indole ring was significantly different from those of the complex without the side-chain indole ring, and the absorption and CD spectra exhibited a solvent dependence, which is in line with the phenoxyl radical-indole stacking interaction in solution The other physicochem. results and theor. calculations strongly support that the indole ring, as an electron donor, stabilizes the phenoxyl radical by the π-π stacking interaction.

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Quinoxaline – Wikipedia,
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Recommanded Product: (S)-Propane-1,2-diamine dihydrochloride. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2. Author is Armstrong, Daniel W.; He, Lingfeng; Yu, Timothy; Lee, Jauh T.; Liu, Yan-song.

The enantiomeric purity of reagents used in asym. synthesis is of fundamental importance when evaluating the selectivity of a reaction and the product purity. In this work, 109 chiral reagents (many recently introduced) are assayed. Approx. 64% of these reagents had moderate to high levels of enantiomeric impurities (i.e. from >0.1% to <16%). The type of chiral reagents assayed and used in enantioselective synthesis include metal-ligand catalysts for allylic substitutions, catalysts for addition of Grignard reagents and other additions, epoxidations and reduction of ketones and aldehydes; Ru-complex auxiliaries for asym. cyclopropanation, as well as amine, diamine, alc., diol, amino alc., carboxylic acid and oxazolidinone auxiliaries; epoxide, lactone, furanone, pyrrolidinone, nitrile, sulfoximine and carboxylic acid synthons (including malic acid, mandelic acid, lactic acid and tartaric acid); and a variety of chiral resolving agents. Accurate, efficient assays for all compounds are given. There is still a lot of research devoted to this compound(SMILES：C[C@H](N)CN.[H]Cl.[H]Cl)Recommanded Product: (S)-Propane-1,2-diamine dihydrochloride, and with the development of science, more effects of this compound(19777-66-3) can be discovered.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 19777-66-3, is researched, Molecular C3H12Cl2N2, about Synthesis of a water-soluble chiral NMR shift reagent: (S)-PDTA, the main research direction is alanine transformation chirality retention; PDTA water soluble chiral NMR shift reagent stereoselective preparation; propylenediamine tetraacetic acid stereoselective preparation.Reference of (S)-Propane-1,2-diamine dihydrochloride.

A five-step synthesis of the water-soluble chiral polydentate ligand, (S)-PDTA (I) starting from L-alanine has been worked out, via 5 steps with retention of chirality. The total yield is 50.7% (average of ∼88% for each step), while published methods report 33.4% total yield over four steps.

There is still a lot of research devoted to this compound(SMILES：C[C@H](N)CN.[H]Cl.[H]Cl)Reference of (S)-Propane-1,2-diamine dihydrochloride, and with the development of science, more effects of this compound(19777-66-3) can be discovered.

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Quinoxaline – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 19777-66-3, is researched, Molecular C3H12Cl2N2, about Synthesis of dexrazoxane, the main research direction is dexrazoxane synthesis diaminopropane.Application of 19777-66-3.

Dexrazoxane, a cardiac medicine, was synthesized in 35.7% overall yield starting from racemic 1,2-diaminopropane. The resolution of l,2-diaminopropane with D-(-)-tartaric acid followed by reaction with potassium chloride resulted in (S)-1,2-diaminopropane dihydrochloride, which was further converted into the title compound in two steps. The structure was confirmed with 1H NMR and IR.

There is still a lot of research devoted to this compound(SMILES：C[C@H](N)CN.[H]Cl.[H]Cl)Application of 19777-66-3, and with the development of science, more effects of this compound(19777-66-3) can be discovered.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists, the main research direction is dihydrotriazolopyrazinone P2X7 receptor antagonist SAR preparation; 6,7-Dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one; Autoradiography; CNS; Depression; P2X7.Computed Properties of C3H12Cl2N2.

The synthesis, SAR, and preclin. characterization of a series of substituted 6,7-dihydro[1,2,4]triazolo[4,3]pyrazin-8(5H)-one P2X7 receptor antagonists are described. Optimized leads from this series comprise some of the most potent human P2X7R antagonists reported to date (IC50s < 1 nM). They also exhibit sufficient potency and oral bioavailability in rat to enable extensive in vivo profiling. Although many of the disclosed compounds are peripherally restricted, compound I is brain penetrant and upon oral administration demonstrated dose-dependent target engagement in rat hippocampus as determined by ex vivo receptor occupancy with radiotracer II (ED50 = 0.8 mg/kg). There is still a lot of research devoted to this compound(SMILES：C[C@H](N)CN.[H]Cl.[H]Cl)Computed Properties of C3H12Cl2N2, and with the development of science, more effects of this compound(19777-66-3) can be discovered.

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Quinoxaline – Wikipedia,
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