Category: 19777-66-3

Park, Jae-Hoon; Ha, Hyun-Joon; Lee, Won Koo; Genereux-Vincent, Tobie; Kazlauskas, Romas J. published an article about the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3,SMILESS:C[C@H](N)CN.[H]Cl.[H]Cl ).Electric Literature of C3H12Cl2N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:19777-66-3) through the article.

Candida antarctica lipase B was used to catalyzed a stereoselective ammonolysis of N-(alkyl)aziridine-2-carboxylates in tert-butanol with ammonia and yielded (2S)-2-aziridinecarboxamide and remaining (2R)-2-aziridinecarboxylic acid ester. Varying the N-1 substituent on the aziridine ring changed the rate and stereoselectivity of the reaction. Substrates with a benzyl substituent or a (1R)-1-phenylethyl substituent reacted approx. ten times faster than substrates with a (1S)-1-phenylethyl substituent. Substrates with a benzyl substituent showed little stereoselectivity (E = 5-7) while substrates with either a (1R)-1-phenylethyl or (1S)-1-phenylethyl substituent showed high stereoselectivity (D > 50). Mol. modeling by using the current paradigm for enantioselectivity-binding of the slow enantiomer by an exchange-of-substituents orientation-could not account for the exptl. results. However, modeling an umbrella-like-inversion orientation for the slow enantiomer could account for the exptl. results. Steric hindrance between a Me group in the (1S)-1-phenylethyl substituent and Thr138 and Ile189 in the acyl-binding site likely accounts for the slow reaction. Enantioselectivity likely stems from an unfavorable interaction of the methine hydrogen with Thr40 for the slow enantiomer and from subtle differences in the orientations of the other three substituents. This success in rationalizing the enantioselectivity supports the notion that an umbrella-like-inversion orientation can contribute to enantioselectivity in lipases.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 19777-66-3, is researched, SMILESS is C[C@H](N)CN.[H]Cl.[H]Cl, Molecular C3H12Cl2N2Journal, Tetrahedron: Asymmetry called Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2, Author is Armstrong, Daniel W.; He, Lingfeng; Yu, Timothy; Lee, Jauh T.; Liu, Yan-song, the main research direction is enantiomeric purity chiral catalyst auxiliary synthon resolving agent.Reference of (S)-Propane-1,2-diamine dihydrochloride.

The enantiomeric purity of reagents used in asym. synthesis is of fundamental importance when evaluating the selectivity of a reaction and the product purity. In this work, 109 chiral reagents (many recently introduced) are assayed. Approx. 64% of these reagents had moderate to high levels of enantiomeric impurities (i.e. from >0.1% to <16%). The type of chiral reagents assayed and used in enantioselective synthesis include metal-ligand catalysts for allylic substitutions, catalysts for addition of Grignard reagents and other additions, epoxidations and reduction of ketones and aldehydes; Ru-complex auxiliaries for asym. cyclopropanation, as well as amine, diamine, alc., diol, amino alc., carboxylic acid and oxazolidinone auxiliaries; epoxide, lactone, furanone, pyrrolidinone, nitrile, sulfoximine and carboxylic acid synthons (including malic acid, mandelic acid, lactic acid and tartaric acid); and a variety of chiral resolving agents. Accurate, efficient assays for all compounds are given. If you want to learn more about this compound((S)-Propane-1,2-diamine dihydrochloride)Reference of (S)-Propane-1,2-diamine dihydrochloride, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(19777-66-3).

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Category: quinoxaline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Modified amino acids and peptides. Part 2. A convenient conversion of amino and peptide alcohols into amines.

A convenient general method for the conversion of N-protected amino and peptide alcs. RNHCHR1CH2R2 (I; R = Z, Boc, Z-Ala, R1 = H, PhCH2, Me, CH2CHMe2, R2 = OH; Z = PhCH2O2C, Boc = Me3CO2C) into amines I (R2 = NH2, NEt2) is described. Thus, treatment of I (R = OH) with MeSO2Cl gave the corresponding mesylates, which underwent substitution with HNEt2 to give I (R2 = NEt2) or NaN3 to give the corresponding azides I (R2 = N3). Hydrogenation of I (R2 = N3) gave the corresponding monoprotected diamines I (R = Boc, R2 = NH2) or free diamines I (R = H, R2 = NH2), depending on the protecting group. Selective reduction of the azido group in I (R = Z, R2 = N3) was performed in high yield using NaBH4 in the presence of 10% Pd/C to give I (R = Z, R2 = NH2).

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Product Details of 19777-66-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Optically active complexes of Schiff bases. I. Syntheses and properties of optically active tetradentate Schiff bases.

Reproducible syntheses and resolutions of 1,2-diamines were reported. Isomeric Schiff bases were prepared by condensation of 1 mole of (+),(-), or meso-1,2-diamine with 2 moles MeCOCH2COMe, salicylaldehyde or (+)-hydroxymethylenecamphor and identified by NMR and ir spectra. Configurational studies of the Schiff bases were made on the basis of ORD and CD spectra.

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Category: quinoxaline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about From Mesocates to Helicates: Structural, Magnetic and Chiro-Optical Studies on Nickel(II) Supramolecular Assemblies Derived from Tetradentate Schiff Bases. Author is Mayans, Julia; Font-Bardia, Merce; Di Bari, Lorenzo; Arrico, Lorenzo; Zinna, Francesco; Pescitelli, Gennaro; Escuer, Albert.

The systematic reactions of a family of tetradentate pyridyl/imine and quinolyl/imine racemic or enantiopure Schiff bases with Ni(NO3)2 or Ni(ClO4)2 in the presence of sodium azide yielded, as a function of the starting racemic, chiral or achiral base, a set of chiral, meso or achiral complexes. In all cases, the compounds consist of two NiII cations linked by a double azido bridge in its end-on coordination mode. All the dimers exhibit a mesocate supramol. structure and one of them, the unprecedented mix of helicate and mesocate in 2:1 ratio. The transition from mesocate to helicate conformation was reached by tuning the flexibility of the central spacers of the Schiff bases and the size of the substituents. Electronic CD (ECD) studies were performed for two pairs of enantiomers and interpreted by DFT calculations Susceptibility measurements show a ferromagnetic coupling between the NiII cations mediated by the end-on azido bridges.

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Formula: C3H12Cl2N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Topography of nucleic acid helices in solutions. IX. Models for the interactions of optically active diamines, amino acid amides, diamino acids, and lysyl dipeptides with nucleic acid systems. Author is Gabbay, Edmond J..

Mol. framework models of the complexes formed between the salts N+H3CHRCONHCH2CH2N+Me2N.2Br- (I), N+H3C(CO2-)H(CH2)nH+H3Cl- (n = 2, 3, and 4) (II), N+HEC[CH2]4N+H3]HCONHCHRCO2-Cl-, (III), and N+H3CHRCH2N+H3.2Cl- (R = Me and CO2H) (IV) and adjacent phosphate anions of a helical polynucleotide chain were examined in detail; 15-, 16-, 17-, and 18-membered rings are formed as the result of complexing the salts I-IV to the nucleic acid helix. Certain conformations are not as favorable as other. Moreover, it is possible to predict which of the two optical isomers of I-IV should interact to a greater extent with a nucleic acid helix. The results using 11 different sets of optical isomers of I-IV on three different helical structures, i.e., poly I-poly C, poly A-poly U, and calf thymus DNA, were predicted correctly and consistently.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Molecular Basis for the Stereoselective Ammonolysis of N-Alkyl Aziridine-2-Carboxylates Catalyzed by Candida antarctica Lipase B》. Authors are Park, Jae-Hoon; Ha, Hyun-Joon; Lee, Won Koo; Genereux-Vincent, Tobie; Kazlauskas, Romas J..The article about the compound:(S)-Propane-1,2-diamine dihydrochloridecas:19777-66-3,SMILESS:C[C@H](N)CN.[H]Cl.[H]Cl).Reference of (S)-Propane-1,2-diamine dihydrochloride. Through the article, more information about this compound (cas:19777-66-3) is conveyed.

Candida antarctica lipase B was used to catalyzed a stereoselective ammonolysis of N-(alkyl)aziridine-2-carboxylates in tert-butanol with ammonia and yielded (2S)-2-aziridinecarboxamide and remaining (2R)-2-aziridinecarboxylic acid ester. Varying the N-1 substituent on the aziridine ring changed the rate and stereoselectivity of the reaction. Substrates with a benzyl substituent or a (1R)-1-phenylethyl substituent reacted approx. ten times faster than substrates with a (1S)-1-phenylethyl substituent. Substrates with a benzyl substituent showed little stereoselectivity (E = 5-7) while substrates with either a (1R)-1-phenylethyl or (1S)-1-phenylethyl substituent showed high stereoselectivity (D > 50). Mol. modeling by using the current paradigm for enantioselectivity-binding of the slow enantiomer by an exchange-of-substituents orientation-could not account for the exptl. results. However, modeling an umbrella-like-inversion orientation for the slow enantiomer could account for the exptl. results. Steric hindrance between a Me group in the (1S)-1-phenylethyl substituent and Thr138 and Ile189 in the acyl-binding site likely accounts for the slow reaction. Enantioselectivity likely stems from an unfavorable interaction of the methine hydrogen with Thr40 for the slow enantiomer and from subtle differences in the orientations of the other three substituents. This success in rationalizing the enantioselectivity supports the notion that an umbrella-like-inversion orientation can contribute to enantioselectivity in lipases.

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Application of 19777-66-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Resolution of propandiamine and synthesis of dexrazoxane. Author is Wang, Yuling; Song, Hongrui; Song, Aihua.

The resolution of propandiamine and synthesis of dexrazoxane were studied. Using 1,2-propandiamine as primary material, the synthetic method of dexrazoxane by resolution, alkylation and cyclization was established. The L-tartaric acid was used as a resolving reagent, 1,2-propandiamine was resolved and the (+)-enantiomer was obtained. The method of changing 1,2-propandiamine bitartrate into hydrochloride was improved. The method was simpler and might be of application.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Cold Crystallization of Chiral Schiff-Base Nickel(II) Complex Having Alkyl Chains and a Characteristic Methyl Group.Related Products of 19777-66-3.

Mols. exhibiting cold crystallization, an exothermic phenomenon in heating following supercooling, can be used as a heat storing material. However, examples in nonpolymers are still few. A chiral Schiff-base nickel(II) complex, which had a characteristic Me group and long alkyl chains, exhibited complicated thermal behavior including cold crystallization The Me group was a steric barrier to dimerization and mol. stacking, leading to the supercooled state. The thermal behavior of enantiomer was different from that of racemate.

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Zhou, Kai; Zelder, Felix published the article 《Vitamin B12 Mimics Having a Peptide Backbone and Tuneable Coordination and Redox Properties》. Keywords: vitamin B12 mimic preparation redox dissociation equilibrium; cobalt corrin preparation redox dissociation equilibrium.They researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Computed Properties of C3H12Cl2N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:19777-66-3) here.

The coordination chem. and electrochem. properties of vitamin B12 mimics were studied. The model complexes have a peptide linkage between the corrin macrocycle and the axially coordinated dimethylbenzimidazole base. The dimethylbenzimidazole dissociation and Co(III)/Co(II) redox equilibrium were studied in relation to the peptide linking groups.

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