Category: 212327-10-1

Brief introduction of 212327-10-1

As the paragraph descriping shows that 212327-10-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.212327-10-1,7-Bromo-2-methoxyquinoxaline,as a common compound, the synthetic route is as follows.

Under an argon atmosphere, 140 mg (0.586 mmol) of example 74A was dissolved in 15 ml dioxane. Then 172 mg (1.76 mmol) potassium acetate, 38 mg (0.047 mmol) of 1,1 ‘-bis- (diphenylphosphino)ferrocene palladium(II) chloride-dichloromethane complex and 163 mg (0.644 mmol) of 4,4,4’4l5,5,5’5′-octamethyl-2,2’-bi-l,3,2-dioxaborolan were added. The reaction mixture was stirred overnight at 1300C oil bath temperature. After cooling, dioxane was added to the reaction mixture and it was filtered on kieselguhr. It was washed again with ethyl acetate. The filtrate was concentrated in a rotary evaporator at reduced pressure and dried under high vacuum. We obtained 152 mg of 2-methoxy-7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)quinoxaline as raw product. This was reacted subsequently without further purification., 212327-10-1

As the paragraph descriping shows that 212327-10-1 is playing an increasingly important role.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan; WO2010/20363; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

New learning discoveries about 212327-10-1

212327-10-1, 212327-10-1 7-Bromo-2-methoxyquinoxaline 1237168, aquinoxaline compound, is more and more widely used in various fields.

212327-10-1, 7-Bromo-2-methoxyquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0211] To a solution of 7-bromo-2-methoxyquinoxaline (26.7 g, 0.11 mol, 1.0 eq.) in DMF (1100 mL) were added TEA (77.7 mL, 0.56 mol, 5.0 eq.), Et3SiH (71.2 mL, 0.45 mol, 4.0 eq.) and Pd(dppf)Cl2CH2Cl2 (4.56 g, 5.6 mmol, 0.05 eq.). The resulting mixture was stirred at 90 C in an autoclave for 12 h under CO (1 MPa), then cooled and concentrated. The resulting residue was purified via flash column chromatography (EA/PE=l/4, v/v) to afford 3-methoxyquinoxaline-6-carbaldehyde as a white solid (8.5 g, 40.5%yield).

212327-10-1, 212327-10-1 7-Bromo-2-methoxyquinoxaline 1237168, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2014/75077; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

Simple exploration of 212327-10-1

212327-10-1, The synthetic route of 212327-10-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.212327-10-1,7-Bromo-2-methoxyquinoxaline,as a common compound, the synthetic route is as follows.

0306] To a solution of 7-bromo-2-methoxyquinoxaline (24.1 g, 100 mmol, 1 eq.) in DMF (50 mL) and EtOH ( 250 mL ) was added NaOAc (32.8 g, 400 mmol, 4 eq.) and Pd(dppf)Cl2 (1.63 g, 2 mmol, 0.02 eq) under N2 protection. The resulting mixture was stirred at 90 C under CO (3 MPa) overnight, then cooled to rt, filtered and concentrated to afford crude ethyl 3-methoxyquinoxaline-6- carboxylate as a brown solid (23.2 g, 100%) which used in next step without further purification

212327-10-1, The synthetic route of 212327-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/40515; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider