Category: 217192-22-8

Safety of (4-(Pyridin-4-yl)phenyl)methanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. Author is Iwamura, Ryo; Tanaka, Masayuki; Okanari, Eiji; Kirihara, Tomoko; Odani-Kawabata, Noriko; Shams, Naveed; Yoneda, Kenji.

EP2 receptor agonists are expected to be effective ocular hypotensive agents; however, it has been suggested that agonism to other EP receptor subtypes may lead to undesirable effects. Through medicinal chem. efforts, we identified a scaffold bearing a (pyridin-2-ylamino)acetic acid moiety as a promising EP2-selective receptor agonist. (6-((4-(Pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid 13ax (omidenepag, OMD) exerted potent and selective activity toward the human EP2 receptor (h-EP2). Low doses of omidenepag iso-Pr (OMDI), a prodrug of 13ax, lowered intraocular pressure (IOP) in ocular normotensive monkeys. OMDI was selected as a clin. candidate for the treatment of glaucoma.

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Related Products of 217192-22-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about In situ-prepared homogeneous supramolecular organic framework drug delivery systems (sof-DDSs): Overcoming cancer multidrug resistance and controlled release. Author is Tian, Jia; Yao, Chi; Yang, Wen-Lin; Zhang, Lei; Zhang, Dan-Wei; Wang, Hui; Zhang, Fan; Liu, Yi; Li, Zhan-Ting.

Water-soluble three-dimensional porous supramol. organic frameworks (SOFs) have been demonstrated as a new generation of homogeneous polycationic platforms for anti-cancer drug delivery. The new SOF drug delivery systems (sof-DDSs) can adsorb dianionic pemetrexed (PMX), a clin. used chemotherapeutic agent instantaneously upon dissolving in water, which is driven by both electrostatic attraction and hydrophobicity. The in situ-prepared PMX@SOFs are highly stable and can avoid important release of the drug during plasm circulation and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells to enter the cancer cells. Acidic microenvironment of cancer cells promotes the release of the drug in cancer cells. Both in vitro and in vivo studies have revealed that sof-DDSs considerably improve the treatment efficacy of PMX, leading to 6-12-fold reduction of the IC50 values, as compared with that of PMX alone. The new drug delivery strategy omits the loading process required by most of reported nanoparticle-based delivery systems and thus holds promise for future development of low-cost drug delivery systems.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Inorganica Chimica Acta called Cationic cyclopalladated ferrocenylpyrimidine complex as an efficient catalyst for the synthesis of substituted biarylmethanol by the Suzuki reaction in water, Author is Li, Hong-Mei; Xu, Chen; Hao, Xin-Qi; Li, Zhen; Wang, Zhi-Qiang; Fu, Wei-Jun; Song, Mao-Ping, which mentions a compound: 217192-22-8, SMILESS is OCC1=CC=C(C2=CC=NC=C2)C=C1, Molecular C12H11NO, Synthetic Route of C12H11NO.

A new cationic cyclopalladated ferrocenylpyrimidine 2 has been synthesized and characterized by elemental anal., IR, 1H and C13 NMR. Addnl., its detailed structure has been determined by single-crystal x-ray diffraction and intermol. C-H···O hydrogen bonds were found in the its crystal. 2 Was successfully used in Suzuki reaction of aryl bromides or chlorides excluding water-soluble group with 4-(hydroxymethyl)phenylboronic acid for the synthesis of substituted biarylmethanol in water. Complex 2 was very efficient for these reactions. Typically, using 0.5-1 mol% of catalyst in the presence of 3 equivalent of K3PO4·3H2O as base in water at 100° provided coupling products in good yields.

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SDS of cas: 217192-22-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about A Switchable Catalyst Duo for Acyl Transfer Proximity Catalysis and Regulation of Substrate Selectivity.

Enzymes are encoded with a gamut of information to catalyze a highly selective transformation by selecting the proper reactants from an intricate mixture of constituents. Mimicking biol. machinery, two switchable catalysts with differently sized cavities and allosteric control are conceived that allow complementary size-selective acyl transfer in an on/off manner by modulating the effective local concentration of the substrates. Selective activation of one of two catalysts in a mixture of reactants of similar reactivity enabled upregulation of the desired product.

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Synthetic Route of C12H11NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Tripodal 4-Pyridyl-Derived Host Ligands and Their Metallo-Supramolecular Chemistry: Stella Octangula and Bowl-Shaped Assemblies.

The synthesis of five new cyclotriveratrylene derivatives with 4-pyridyl side arms is reported, along with the crystal structures of three of these. Three ligands with extended 4-pyridylphenyl side arms and a ligand derived from cyclotriphenolene form [Pd6L8]12+ stella octangula assemblies using diffusion-ordered spectroscopy NMR and electrospray MS techniques. This confirms the generality of the stella octangula assembly, providing that the ligand arms show a degree of rigidity. The more flexible ether-linked ligand tris(4-pyridylmethyl)cyclotriguaiacylene forms a smaller [Pd3L4]6+ bowl-shaped assembly in the solid state and in solution The previously reported ligand tris(4-pyridylmethylamino)cyclotriguaiacylene forms a similar assembly in solution

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Application of 217192-22-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Rotaxanes Based on the 1,2-Bis(pyridinio)ethane-24-Crown-8 Templating Motif.

The supramol. interaction between 1,2-bis(pyridinio)ethane axles and 24-membered crown ether wheels provides a template for the formation of interpenetrated [2]pseudorotaxanes. The preformed [2]pseudorotaxanes can then be kinetically trapped to produce permanently interlocked [2]rotaxanes by stoppering with bulky groups that prevent the unthreading of the resulting dumbbell from the wheel. Six [2]rotaxanes were created using 24-crown-8 (24C8), dibenzo-24-crown-8 (DB24C8) and dinaphtho-24-crown-8 (DN24C8) as the wheel and two methods of stoppering; alkylation of a terminal pyridine with tert-butylbenzyl groups and esterification of a terminal benzyl alc. with p-(tert-butyl)benzoate groups. The [2]rotaxanes were characterized by 1H NMR spectroscopy, electro-spray mass spectrometry and X-ray crystallog.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 217192-22-8, is researched, Molecular C12H11NO, about Rotaxanes Based on the 1,2-Bis(pyridinio)ethane-24-Crown-8 Templating Motif, the main research direction is rotaxane bispyridinioethane crown templating motif.Name: (4-(Pyridin-4-yl)phenyl)methanol.

The supramol. interaction between 1,2-bis(pyridinio)ethane axles and 24-membered crown ether wheels provides a template for the formation of interpenetrated [2]pseudorotaxanes. The preformed [2]pseudorotaxanes can then be kinetically trapped to produce permanently interlocked [2]rotaxanes by stoppering with bulky groups that prevent the unthreading of the resulting dumbbell from the wheel. Six [2]rotaxanes were created using 24-crown-8 (24C8), dibenzo-24-crown-8 (DB24C8) and dinaphtho-24-crown-8 (DN24C8) as the wheel and two methods of stoppering; alkylation of a terminal pyridine with tert-butylbenzyl groups and esterification of a terminal benzyl alc. with p-(tert-butyl)benzoate groups. The [2]rotaxanes were characterized by 1H NMR spectroscopy, electro-spray mass spectrometry and X-ray crystallog.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Aerobic Oxidation of Alcohols and the Synthesis of Benzoxazoles Catalyzed by a Cuprocupric Coordination Polymer (Cu+-CP) Assisted by TEMPO, the main research direction is sulfonylquinolinyloxyphthalate copper salt preparation crystal structure; copper sulfonylquinolinyloxyphthalate bipyridine coordination polymer preparation crystal structure; bipyridylbenzoxazole preparation crystal structure; aerobic oxidation alc copper sulfonylquinolinyloxyphthalate bipyridine catalyst TEMPO cocatalyst; benzyl alc aminophenol oxidative cyclization copper sulfonylquinolinyloxyphthalate bipyridine catalyst; biarylmethanol aminophenol oxidative cyclization copper sulfonylquinolinyloxyphthalate bipyridine catalyst; benzoxazole preparation.Electric Literature of C12H11NO.

A Cu+-coordination polymer (CP) based on the tetranuclear unit {[(HSQPA)2Cu4(bipy)4]·2H2O}n·2nH2O was constructed through Cu2+ salt, 2-(sulfonylquinolin-8-yloxy)phthalic acid (H3SQPA), and 4,4′-bipyridine (bipy). This Cu+-CP combined with 2,2,6,6-tetramethylpiperidine-1-oxyl as the cocatalyst is an effective catalyst for aerobic oxidation of alcs. and the synthesis of benzoxazoles and can be recycled at least four times without losing its catalytic activity.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.Related Products of 217192-22-8.

Protein-protein interactions are difficult therapeutic targets, and inhibiting pathol. relevant interactions without disrupting other essential ones presents an addnl. challenge. Herein the authors report how this might be achieved for the potential anticancer target, the TPX2-importin-α interaction. Importin-α is a nuclear transport protein that regulates the spindle assembly protein TPX2. It has two binding sites-major and minor-to which partners bind. Most nuclear transport cargoes use the major site, whereas TPX2 binds principally to the minor site. Fragment-based approaches were used to identify small mols. that bind importin-α, and crystallog. studies identified a lead series that was observed to bind specifically to the minor site, representing the first ligands specific for this site. Structure-guided synthesis informed the elaboration of these fragments to explore the source of ligand selectivity between the minor and major sites. These ligands are starting points for the development of inhibitors of this protein-protein interaction.

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Name: (4-(Pyridin-4-yl)phenyl)methanol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Colour coding the co-conformations of a [2]rotaxane flip-switch. Author is Suhan, Natalie D.; Allen, Laura; Gharib, Mireille T.; Viljoen, Elizabeth; Vella, Sarah J.; Loeb, Stephen J..

Fine-tuning the charge transfer chromophores in a series of [2]rotaxane flip-switches yields a unique optical signal (purple color) for one of the interactions allowing for facile determination of the position of the flip-switch equilibrium

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Quinoxaline – Wikipedia,
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