Category: 217192-22-8

Application of 217192-22-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. Author is Chenge, Jude T.; Van Duyet, Le; Swami, Shalini; McLean, Kirsty J.; Kavanagh, Madeline E.; Coyne, Anthony G.; Rigby, Stephen E. J.; Cheesman, Myles R.; Girvan, Hazel M.; Levy, Colin W.; Rupp, Bernd; von Kries, Jens P.; Abell, Chris; Leys, David; Munro, Andrew W..

The Mycobacterium tuberculosis H37Rv genome encodes 20 cytochromes P 450, including P450s crucial to infection and bacterial viability. Many M. tuberculosis P450s remain uncharacterized, suggesting that their further anal. may provide new insights into M. tuberculosis metabolic processes and new targets for drug discovery. CYP126A1 is representative of a P 450 family widely distributed in mycobacteria and other bacteria. Here we explore the biochem. and structural properties of CYP126A1, including its interactions with new chem. ligands. A survey of azole antifungal drugs showed that CYP126A1 is inhibited strongly by azoles containing an imidazole ring but not by those tested containing a triazole ring. To further explore the mol. preferences of CYP126A1 and search for probes of enzyme function, we conducted a high throughput screen. Compounds containing three or more ring structures dominated the screening hits, including nitroarom. compounds that induce substrate-like shifts in the heme spectrum of CYP126A1. Spectroelectrochem. measurements revealed a 155-mV increase in heme iron potential when bound to one of the newly identified nitroarom. drugs. CYP126A1 dimers were observed in crystal structures of ligand-free CYP126A1 and for CYP126A1 bound to compounds discovered in the screen. However, ketoconazole binds in an orientation that disrupts the BC-loop regions at the P 450 dimer interface and results in a CYP126A1 monomeric crystal form. Structural data also reveal that nitroarom. ligands “”moonlight”” as substrates by displacing the CYP126A1 distal water but inhibit enzyme activity. The relatively polar active site of CYP126A1 distinguishes it from its most closely related sterol-binding P450s in M. tuberculosis, suggesting that further investigations will reveal its diverse substrate selectivity.

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Related Products of 217192-22-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Colour coding the co-conformations of a [2]rotaxane flip-switch. Author is Suhan, Natalie D.; Allen, Laura; Gharib, Mireille T.; Viljoen, Elizabeth; Vella, Sarah J.; Loeb, Stephen J..

Fine-tuning the charge transfer chromophores in a series of [2]rotaxane flip-switches yields a unique optical signal (purple color) for one of the interactions allowing for facile determination of the position of the flip-switch equilibrium

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 217192-22-8, is researched, SMILESS is OCC1=CC=C(C2=CC=NC=C2)C=C1, Molecular C12H11NOJournal, Inorganica Chimica Acta called Cationic cyclopalladated ferrocenylpyrimidine complex as an efficient catalyst for the synthesis of substituted biarylmethanol by the Suzuki reaction in water, Author is Li, Hong-Mei; Xu, Chen; Hao, Xin-Qi; Li, Zhen; Wang, Zhi-Qiang; Fu, Wei-Jun; Song, Mao-Ping, the main research direction is cationic cyclopalladated ferrocenylpyrimidine catalyst preparation crystal mol structure catalyst; Suzuki reaction aryl halide hydroxymethyl phenylboronic acid cyclopalladated ferrocenylpyrimidine.Reference of (4-(Pyridin-4-yl)phenyl)methanol.

A new cationic cyclopalladated ferrocenylpyrimidine 2 has been synthesized and characterized by elemental anal., IR, 1H and C13 NMR. Addnl., its detailed structure has been determined by single-crystal x-ray diffraction and intermol. C-H···O hydrogen bonds were found in the its crystal. 2 Was successfully used in Suzuki reaction of aryl bromides or chlorides excluding water-soluble group with 4-(hydroxymethyl)phenylboronic acid for the synthesis of substituted biarylmethanol in water. Complex 2 was very efficient for these reactions. Typically, using 0.5-1 mol% of catalyst in the presence of 3 equivalent of K3PO4·3H2O as base in water at 100° provided coupling products in good yields.

There is still a lot of research devoted to this compound(SMILES：OCC1=CC=C(C2=CC=NC=C2)C=C1)Reference of (4-(Pyridin-4-yl)phenyl)methanol, and with the development of science, more effects of this compound(217192-22-8) can be discovered.

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Related Products of 217192-22-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about A Switchable Catalyst Duo for Acyl Transfer Proximity Catalysis and Regulation of Substrate Selectivity. Author is Goswami, Abir; Gaikwad, Sudhakar; Schmittel, Michael.

Enzymes are encoded with a gamut of information to catalyze a highly selective transformation by selecting the proper reactants from an intricate mixture of constituents. Mimicking biol. machinery, two switchable catalysts with differently sized cavities and allosteric control are conceived that allow complementary size-selective acyl transfer in an on/off manner by modulating the effective local concentration of the substrates. Selective activation of one of two catalysts in a mixture of reactants of similar reactivity enabled upregulation of the desired product.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (4-(Pyridin-4-yl)phenyl)methanol( cas:217192-22-8 ) is researched.Computed Properties of C12H11NO.Mercer, Darren J.; Vukotic, V. Nicholas; Loeb, Stephen J. published the article 《Linking [2]rotaxane wheels to create a new type of metal organic rotaxane framework》 about this compound( cas:217192-22-8 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: cadmium aromatic nitrogen substituted benzocrown pyridinioethane rotaxane complex preparation; crystal structure cadmium aromatic nitrogen substituted benzocrown pyridinioethane rotaxane. Let’s learn more about this compound (cas:217192-22-8).

Three new [2]rotaxanes with aromatic nitrogen donors appended to the crown ether wheel were synthesized by the combination of tetraarom. nitrogen group substituted dibenzo-24-crown-8 ether wheel (tetraarom. nitrogen group = 8-hydroxyquinoline, 3-pyridyl, 4-pyridyl) and a dicationic 1,2-bis(pyridinium)ethane axle and used as ligands to coordinate Cd(II) ions. One of these yields a new type of 2-periodic, metal organic rotaxane framework in which the wheel rather than the axle was used to link the metal nodes. The cadmium complexes and reactant precursor were characterized via x-ray determination

If you want to learn more about this compound((4-(Pyridin-4-yl)phenyl)methanol)Computed Properties of C12H11NO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(217192-22-8).

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Product Details of 217192-22-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Linking [2]rotaxane wheels to create a new type of metal organic rotaxane framework.

Three new [2]rotaxanes with aromatic nitrogen donors appended to the crown ether wheel were synthesized by the combination of tetraarom. nitrogen group substituted dibenzo-24-crown-8 ether wheel (tetraarom. nitrogen group = 8-hydroxyquinoline, 3-pyridyl, 4-pyridyl) and a dicationic 1,2-bis(pyridinium)ethane axle and used as ligands to coordinate Cd(II) ions. One of these yields a new type of 2-periodic, metal organic rotaxane framework in which the wheel rather than the axle was used to link the metal nodes. The cadmium complexes and reactant precursor were characterized via x-ray determination

If you want to learn more about this compound((4-(Pyridin-4-yl)phenyl)methanol)Product Details of 217192-22-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(217192-22-8).

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, ChemMedChem called Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design, Author is Holvey, Rhian S.; Valkov, Eugene; Neal, David; Stewart, Murray; Abell, Chris, which mentions a compound: 217192-22-8, SMILESS is OCC1=CC=C(C2=CC=NC=C2)C=C1, Molecular C12H11NO, Related Products of 217192-22-8.

Protein-protein interactions are difficult therapeutic targets, and inhibiting pathol. relevant interactions without disrupting other essential ones presents an addnl. challenge. Herein the authors report how this might be achieved for the potential anticancer target, the TPX2-importin-α interaction. Importin-α is a nuclear transport protein that regulates the spindle assembly protein TPX2. It has two binding sites-major and minor-to which partners bind. Most nuclear transport cargoes use the major site, whereas TPX2 binds principally to the minor site. Fragment-based approaches were used to identify small mols. that bind importin-α, and crystallog. studies identified a lead series that was observed to bind specifically to the minor site, representing the first ligands specific for this site. Structure-guided synthesis informed the elaboration of these fragments to explore the source of ligand selectivity between the minor and major sites. These ligands are starting points for the development of inhibitors of this protein-protein interaction.

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Name: (4-(Pyridin-4-yl)phenyl)methanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Colour coding the co-conformations of a [2]rotaxane flip-switch. Author is Suhan, Natalie D.; Allen, Laura; Gharib, Mireille T.; Viljoen, Elizabeth; Vella, Sarah J.; Loeb, Stephen J..

Fine-tuning the charge transfer chromophores in a series of [2]rotaxane flip-switches yields a unique optical signal (purple color) for one of the interactions allowing for facile determination of the position of the flip-switch equilibrium

In some applications, this compound(217192-22-8)Name: (4-(Pyridin-4-yl)phenyl)methanol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Application of 217192-22-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (4-(Pyridin-4-yl)phenyl)methanol, is researched, Molecular C12H11NO, CAS is 217192-22-8, about Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. Author is Iwamura, Ryo; Tanaka, Masayuki; Okanari, Eiji; Kirihara, Tomoko; Odani-Kawabata, Noriko; Shams, Naveed; Yoneda, Kenji.

EP2 receptor agonists are expected to be effective ocular hypotensive agents; however, it has been suggested that agonism to other EP receptor subtypes may lead to undesirable effects. Through medicinal chem. efforts, we identified a scaffold bearing a (pyridin-2-ylamino)acetic acid moiety as a promising EP2-selective receptor agonist. (6-((4-(Pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid 13ax (omidenepag, OMD) exerted potent and selective activity toward the human EP2 receptor (h-EP2). Low doses of omidenepag iso-Pr (OMDI), a prodrug of 13ax, lowered intraocular pressure (IOP) in ocular normotensive monkeys. OMDI was selected as a clin. candidate for the treatment of glaucoma.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Rotaxanes Based on the 1,2-Bis(pyridinio)ethane-24-Crown-8 Templating Motif, published in 2011-03-31, which mentions a compound: 217192-22-8, Name is (4-(Pyridin-4-yl)phenyl)methanol, Molecular C12H11NO, Related Products of 217192-22-8.

The supramol. interaction between 1,2-bis(pyridinio)ethane axles and 24-membered crown ether wheels provides a template for the formation of interpenetrated [2]pseudorotaxanes. The preformed [2]pseudorotaxanes can then be kinetically trapped to produce permanently interlocked [2]rotaxanes by stoppering with bulky groups that prevent the unthreading of the resulting dumbbell from the wheel. Six [2]rotaxanes were created using 24-crown-8 (24C8), dibenzo-24-crown-8 (DB24C8) and dinaphtho-24-crown-8 (DN24C8) as the wheel and two methods of stoppering; alkylation of a terminal pyridine with tert-butylbenzyl groups and esterification of a terminal benzyl alc. with p-(tert-butyl)benzoate groups. The [2]rotaxanes were characterized by 1H NMR spectroscopy, electro-spray mass spectrometry and X-ray crystallog.

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