Category: 221012-82-4

Lam, Kim-Hung; Chui, Chung-Hin; Gambari, Roberto; Wong, Raymond Siu-Ming; Cheng, Gregory Yin-Ming; Lau, Fung-Yi; Lai, Paul Bo-San; Tong, See-Wai; Chan, Kit-Wah; Wong, Wai-Yeung; Chan, Albert Sun-Chi; Tang, Johnny Cheuk-On published the article 《The preparation of bi-functional organophosphine oxides as potential antitumor agents》. Keywords: BINAP P Phos organophosphine oxide preparation potential antitumor agent.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Product Details of 221012-82-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.

Following previously reported pyridinyl phosphine oxides as antitumor agents, the com. available C2-axial chiral organophosphine ligand catalysts, such as 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) 1 and 2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine (P-Phos) 2 as a convenient source for producing organophosphine oxides were targeted as antitumor leads. Their corresponding chiral and racemic bi-phosphine oxides 3 and 4 can be obtained easily through a simple oxidation step with hydrogen peroxide, and their antitumor activities towards human hepatocellular carcinoma Hep3B cell line were reported. It was found that compound 3 shows stronger antitumor activity than that of 4, where axial chirality cannot improve their activity. Further athymic nude mice Hep3B xenograft model demonstrates the attractive in vivo antitumor potential of 3.

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Li, Zhanyu; Zhang, Mengru; Zhang, Yu; Liu, Shuang; Zhao, Jinbo; Zhang, Qian published the article 《Multicomponent Cyclopropane Synthesis Enabled by Cu-Catalyzed Cyclopropene Carbometalation with Organoboron Reagent: Enantioselective Modular Access to Polysubstituted 2-Arylcyclopropylamines》. Keywords: enantioselective multicomponent synthesis arylcyclopropylamine; copper catalyzed cyclopropene carbometalation organoboron reagent.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Computed Properties of C38H34N2O4P2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.

The use of functional-group-tolerant organoboron in lieu of basic organometallic reagents in base-metal-catalyzed cyclopropene carbometalation opens three-component cyclopropane synthesis, as exemplified by the modular assembly of the highly medicinally relevant 2-arylcyclopropylamine (ACPA) framework via stereoselective carboamination. The highly enantioselective version has been realized to afford enantioenriched ACPAs with up to all three cyclopropyl carbons as stereogenic centers in one operation, representing the first example of enantioselective multicomponent cyclopropane synthesis. The reaction significantly improves the efficiency of ACPA synthesis and may inspire the development of other multicomponent cyclopropane syntheses beyond amination.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ) is researched.Quality Control of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.Suzuki, Shunsuke; Shibata, Yu; Tanaka, Ken published the article 《Rhodium-Catalyzed Asymmetric [2+2+2] Cycloaddition of 1,6-Enynes with Racemic Secondary Allylic Alcohols through Kinetic Resolution》 about this compound( cas:221012-82-4 ) in Chemistry – A European Journal. Keywords: bicyclic cyclohexene preparation enantioselective diastereoselective; enyne allylic alc cycloaddition reaction rhodium catalyst; allylic alcohols; asymmetric [2+2+2] cycloaddition; enynes; kinetic resolution; rhodium. Let’s learn more about this compound (cas:221012-82-4).

It has been established that a cationic rhodium(I)/P-phos complex catalyzes the asym. [2+2+2] cycloaddition of 1,6-enynes R1CCCH2ZCH2CH(=CH2)R2 (R1 = Me, Ph, pentyl; R2 = H, Me) with racemic secondary allylic alcs. R3CH(OH)CH=CH2 to produce the corresponding chiral bicyclic cyclohexenes I, possessing three stereogenic centers, as a single diastereomer with excellent ee values. Mechanistic experiments revealed that the present cycloaddition proceeds through the kinetic resolution of the racemic secondary allylic alcs., in which one enantiomer preferentially reacts with the 1,6-enyne.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Multicomponent Cyclopropane Synthesis Enabled by Cu-Catalyzed Cyclopropene Carbometalation with Organoboron Reagent: Enantioselective Modular Access to Polysubstituted 2-Arylcyclopropylamines, the main research direction is enantioselective multicomponent synthesis arylcyclopropylamine; copper catalyzed cyclopropene carbometalation organoboron reagent.Reference of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

The use of functional-group-tolerant organoboron in lieu of basic organometallic reagents in base-metal-catalyzed cyclopropene carbometalation opens three-component cyclopropane synthesis, as exemplified by the modular assembly of the highly medicinally relevant 2-arylcyclopropylamine (ACPA) framework via stereoselective carboamination. The highly enantioselective version has been realized to afford enantioenriched ACPAs with up to all three cyclopropyl carbons as stereogenic centers in one operation, representing the first example of enantioselective multicomponent cyclopropane synthesis. The reaction significantly improves the efficiency of ACPA synthesis and may inspire the development of other multicomponent cyclopropane syntheses beyond amination.

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Quinoxaline – Wikipedia,
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Synthetic Route of C38H34N2O4P2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Asymmetric amidocarbonylation of aldehyde and acetamide catalyzed by chiral palladium or rhodium complexes. Author is Xing, Ai-ping; Wang, Lai-lai; Kwok, Waihim.

The in situ prepared chiral catalyst of Pd/unchelating bidentate phosphine ligand L1 (DPPFF), bipyridine bidentate phosphine ligand L2 (P-PHOS), and bidentate phosphine ligand L3 ((S, Rp) -BPPF), and Rh/phosphite ligands L4-L6, have been applied in amidocarbonylation of cyclohexanecarboxaldehyde or phenylacetaldehyde. Pd/bipyridine bidentate phosphine ligand L2 gave the enantioselectivity 25% (S) and the yield 11% in amidocarbonylation of phenylacetaldehyde, When Pd/unchelating bidentate phosphine ligand L1 was employed in asym. amidocarbonylation of cyclohexanecarboxaldehyde, the enantioselectivity 4.3% (S) and the yield 15% were received.

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Quinoxaline – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 221012-82-4, is researched, Molecular C38H34N2O4P2, about Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio, the main research direction is quinoline alkyl asym hydrogenation iridium spiro diphosphinite; tetrahydroquinoline asym synthesis.Recommanded Product: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

The chiral diphosphinite ligand derived from (R)-1,1′-spirobiindane-7,7′-diol has been found to be highly effective in the Ir-catalyzed asym. hydrogenation of quinolines with high substrate/catalyst ratio (up to 5000) and high enantioselectivity (up to 94% ee).

In some applications, this compound(221012-82-4)Recommanded Product: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Reference of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Nickel-catalyzed asymmetric α-arylation of ketone enolates. Author is Chen, Guoshu; Kwong, Fuk Yee; Chan, Hoi On; Yu, Wing-Yiu; Chan, Albert S. C..

An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates, generated in situ from 1-benzoalkanones, such as 2-methyl-1-tetralone, 2-methyl-1-indanone or 2-methylbenzosuberone, with aryl halides RX (R = Ph, X = Cl, Br, iodo; R = 4-NCC6H4, 4-F3CC6H4, 4-Me3CC6H4, etc., X = Br) to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

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Quinoxaline – Wikipedia,
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Formula: C38H34N2O4P2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Enantioselective bis-alkoxycarbonylation of styrene catalyzed by novel chiral dipyridylphosphine cationic palladium(II) complexes.

The preparation of new palladium complexes that are composed of a series of chiral dipyridylphosphines have been described. The structure of the complex [{(R)-1}Pd(H2O)2](OTf)2 was unambiguously determined by single-crystal X-ray diffractometry. These complexes were found to be effective in the asym. bis-methoxycarbonylation of styrene, reaching up to 84% e.e. and 79% chemoselectivity for dimethyl-2-phenylsuccinate (DMPS) under the optimal conditions. In addition, the complexes exhibited almost identical enantioselectivity on DMPS.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enantioselective Allylation, Crotylation, and Reverse Prenylation of Substituted Isatins: Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation, published in 2009, which mentions a compound: 221012-82-4, mainly applied to benzylisatin stereoselective preparation mechanism; isatin allylacetate allene allylation crotylation prenylation; alkylation transfer hydrogenation iridium catalyst isopropanol, Computed Properties of C38H34N2O4P2.

The first examples of enantioselective catalytic allylations, crotylations, and reverse prenylations of isatin are reported. Unlike conventional allylation methodologies, they have been achieved by isopropanol-mediated transfer hydrogenation without the use of stoichiometric amounts of allylmetal reagents. Activated ketones in the form of substituted isatins were subjected to highly enantioselective carbonyl allylation, crotylation, and reverse prenylation, constituting a convenient synthesis of optically enriched 3-substituted 3-hydroxy-oxindoles, e.g. I.

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Ngamnithiporn, Aurapat; Jette, Carina I.; Bachman, Shoshana; Virgil, Scott C.; Stoltz, Brian M. published the article 《Nickel-catalyzed enantioselective allylic alkylation of lactones and lactams with unactivated allylic alcohols》. Keywords: alpha quaternary lactone enantioselective preparation; lactone allyl alc nickel catalyst allylic alkylation; enantioselective preparation alpha quaternary lactam; lactam allyl alc nickel catalyst allylic alkylation.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.

The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver α-quaternary lactones and lactams bearing an all-carbon quaternary stereocenter I [X = O, N-Bz, R1 = Me, Et; R2 = H, Ph, 2-furanyl, etc.] was reported. The reaction, which utilize a com. available chiral bisphosphine ligand, proceeded in good yield with a high level of enantioselectivity (up to 90% ee) on a range of unactivated allylic alcs. for both lactone and lactam nucleophiles. The utility of this method was further highlighted via a number of synthetically useful product transformations.

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Quinoxaline – Wikipedia,
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