Category: 221012-82-4

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Stereoselective alternating copolymerization of propene and carbon monoxide catalyzed by Pd(II) -chiral ligands treated with BF3 · Et2O, the main research direction is stereoselective alternating polymerization propylene carbon monoxide; palladium phosphine complex boron compound catalyst stereoselective alternating polymerization.COA of Formula: C38H34N2O4P2.

The use of BF3·Et2O as a co-catalyst in the alternating copolymerization of propene and carbon monoxide catalyzed by [L2]Pd (OAC)2 (L2 = chiral diphosphine ligand) in CH2Cl2/CH3OH was reported. High yields of chiral polyketone were obtained. 13C NMR, 1H NMR and molar optical rotation confirmed that the copolymers have an alternating structure and high streroregularity. The IR spectra of the copolymers showed that both spiroketal and pure ketone structures were present at the same time. Low mol. weight and wide polydispersity of the chiral polyketones were achieved.

Here is just a brief introduction to this compound(221012-82-4)COA of Formula: C38H34N2O4P2, more information about the compound((R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine) is in the article, you can click the link below.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 221012-82-4, is researched, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2Journal, Article, Angewandte Chemie, International Edition called Iridium-catalyzed asymmetric hydrogenation of pyridinium salts, Author is Ye, Zhi-Shi; Chen, Mu-Wang; Chen, Qing-An; Shi, Lei; Duan, Ying; Zhou, Yong-Gui, the main research direction is piperidine enantioselective preparation; pyridinium salt preparation enantioselective hydrogenation iridium phosphine ligand catalyst.Product Details of 221012-82-4.

A highly efficient iridium-catalyzed asym. hydrogenation of 2-substituted pyridinium salts is developed. A series of chiral 2-substituted piperidines were obtained in good to excellent yields and up to 93% ee.

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Quinoxaline – Wikipedia,
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Computed Properties of C38H34N2O4P2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Stereoselective alternating copolymerization of propene and carbon monoxide catalyzed by Pd(II) -chiral ligands treated with BF3 · Et2O. Author is Wang, Hai-jun; Li, Cheng; Wang, Lai-lai.

The use of BF3·Et2O as a co-catalyst in the alternating copolymerization of propene and carbon monoxide catalyzed by [L2]Pd (OAC)2 (L2 = chiral diphosphine ligand) in CH2Cl2/CH3OH was reported. High yields of chiral polyketone were obtained. 13C NMR, 1H NMR and molar optical rotation confirmed that the copolymers have an alternating structure and high streroregularity. The IR spectra of the copolymers showed that both spiroketal and pure ketone structures were present at the same time. Low mol. weight and wide polydispersity of the chiral polyketones were achieved.

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Quinoxaline – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, European Journal of Medicinal Chemistry called The preparation of bi-functional organophosphine oxides as potential antitumor agents, Author is Lam, Kim-Hung; Chui, Chung-Hin; Gambari, Roberto; Wong, Raymond Siu-Ming; Cheng, Gregory Yin-Ming; Lau, Fung-Yi; Lai, Paul Bo-San; Tong, See-Wai; Chan, Kit-Wah; Wong, Wai-Yeung; Chan, Albert Sun-Chi; Tang, Johnny Cheuk-On, which mentions a compound: 221012-82-4, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2, Name: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

Following previously reported pyridinyl phosphine oxides as antitumor agents, the com. available C2-axial chiral organophosphine ligand catalysts, such as 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) 1 and 2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine (P-Phos) 2 as a convenient source for producing organophosphine oxides were targeted as antitumor leads. Their corresponding chiral and racemic bi-phosphine oxides 3 and 4 can be obtained easily through a simple oxidation step with hydrogen peroxide, and their antitumor activities towards human hepatocellular carcinoma Hep3B cell line were reported. It was found that compound 3 shows stronger antitumor activity than that of 4, where axial chirality cannot improve their activity. Further athymic nude mice Hep3B xenograft model demonstrates the attractive in vivo antitumor potential of 3.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Recommanded Product: 221012-82-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Atropisomeric [(diphosphine)Au2Cl2] Complexes and their Catalytic Activity Towards Asymmetric Cycloisomerisation of 1,6-Enynes. Author is Barreiro, Elena M.; Boltukhina, Ekaterina V.; White, Andrew J. P.; Hii, King Kuok.

X-ray crystal structures of two [(diphosphine)Au2Cl2] complexes (in which diphosphine = P-Phos and xylyl-P-Phos; P-Phos = [2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine]) were determined and compared to the reported structures of similar atropisomeric gold complexes. Correlations between the Au-Au distances and torsional angles for the biaryl series of ligands (MeOBIPHEP, SEGPhos, and P-Phos; BIPHEP = 2,2′-bis(diphenylphosphino)-1,1′-biphenyl, SEGPhos = [(4,4′-bi-1,3-benzodioxole)-5,5′-diyl]bis[diphenylphosphine]) can be made; these measurements appear to be very dependent upon the phosphorus substituent. Conversely, the same effect was not observed for ligands based on the binaphthyl (BINAP) series. The catalytic activity of these complexes was subsequently assessed in the enantioselective cycloisomerization of 1,6-enynes ArCCCH2OCH2CH:CHC6H5 (Ar = 4-O2NC6H4, 3-CH3OC6H4, C6H5, 4-CH3C6H4) and revealed an over-riding electronic effect: more-electron-rich phosphines promote greater enantioselectivity. The possibility of silver acting as a (co-) catalyst was ruled out in these reactions.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Conference, General Review, e-EROS Encyclopedia of Reagents for Organic Synthesis called 3,3′-Bipyridine, 4,4′-bis(diphenylphosphino)-2,2′,6,6′-tetramethoxy-, (3R)-; 3,3′-Bipyridine, 4,4′-bis(diphenylphosphino)-2,2′,6,6′-tetramethoxy-, (3S)-, Author is Srinivasarao, Madduri, which mentions a compound: 221012-82-4, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2, Related Products of 221012-82-4.

Properties and applications of 3,3′-bipyridine, 4,4′-bis(diphenylphosphino)-2,2′,6,6′-tetramethoxy-, (3R)-; 3,3′-bipyridine, 4,4′-bis(diphenylphosphino)-2,2′,6,6′-tetramethoxy-, (3S)-, a chiral biaryl bisphosphine ligands used for high activity and selectivity in catalytic hydrogenation of ketones, β-ketoesters, α,β-unsaturated carbonyl compounds, quinolines; transfer hydrogenation, Pauson-Khand-type reactions, carbonylation and other reductions are reviewed.

From this literature《3,3′-Bipyridine, 4,4′-bis(diphenylphosphino)-2,2′,6,6′-tetramethoxy-, (3R)-; 3,3′-Bipyridine, 4,4′-bis(diphenylphosphino)-2,2′,6,6′-tetramethoxy-, (3S)-》,we know some information about this compound(221012-82-4)Related Products of 221012-82-4, but this is not all information, there are many literatures related to this compound(221012-82-4).

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ) is researched.Recommanded Product: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.Zhou, Hai-Feng; Fan, Qing-Hua; Tang, Wei-Jun; Xu, Li-Jin; He, Yan-Mei; Deng, Guo-Jun; Zhao, Li-Wen; Gu, Lian-Quan; Chan, Albert S. C. published the article 《Polyethylene glycol as an environmentally friendly and recyclable reaction medium for enantioselective hydrogenation》 about this compound( cas:221012-82-4 ) in Advanced Synthesis & Catalysis. Keywords: polyethylene glycol solvent stereoselective catalytic hydrogenation. Let’s learn more about this compound (cas:221012-82-4).

Polyethylene glycol (PEG) was found to be an inexpensive, non-toxic and recyclable reaction medium for ruthenium- and rhodium-catalyzed asym. hydrogenation of 2-arylacrylic acids (Ru-catalyzed C=C bond reduction), enamides (Rh-catalyzed C=C bond reduction), β-keto esters and simple aromatic ketones (Ru-catalyzed C=O bond reduction). In all cases, high catalytic activities and enantioselectivities have been achieved, which are comparable to those obtained in conventional organic solvent systems. The Ru and Rh catalysts prepared with com. available chiral diphosphine ligands could be readily recycled by simple extraction, as in the case of ionic liquids, and reused up to nine times without obvious loss of catalytic activity and enantioselectivity. The reduced products were obtained from the extracts in high isolated yields. These results indicate that PEGs as new reaction media are attractive alternatives to room temperature ionic liquids

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wu, Jing; Pai, Cheng Chao; Kwok, Wai Him; Guo, Rong Wei; Au-Yeung, Terry T. L.; Yeung, Chi Hung; Chan, Albert S. C. researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Name: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.They published the article 《Studies on the rhodium- and ruthenium-catalyzed asymmetric hydrogenation of α-dehydroamino acids using a family of chiral dipyridylphosphine ligand (P-Phos)》 about this compound( cas:221012-82-4 ) in Tetrahedron: Asymmetry. Keywords: acetamidoarylacrylate asym hydrogenation; dehydroamino acid asym hydrogenation; phenylalanine derivative enantiopure preparation; hydrogenation catalyst chiral dipyridylphosphine rhodium ruthenium preparation. We’ll tell you more about this compound (cas:221012-82-4).

The applications of the chiral dipyridylphosphine ligands I [Ar = Ph, C6H4Me-4, C6H3(Me)2-3,5] in Ru- and Rh-catalyzed hydrogenations of a variety of (Z)-2-acetamido-3-arylacrylates RCH:C(NHCOMe)CO2R1 (R = Ph, C6H4Cl-2, C6H4Cl-3, C6H4Cl-4, C6H4Me-4, C6H4OMe-4, R1 = H, Me) have been studied systematically. The results show that the electronic and steric properties of these ligands have significant influences on the enantioselectivity of the reduction Rh and Ru complexes of the same dipyridylphosphine ligand family exhibit different trends in enantioselectivity toward the same substrate.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chan, Sau Hing; Lam, Kim Hung; Li, Yue-Ming; Xu, Lijin; Tang, Weijun; Lam, Fuk Loi; Lo, Wai Hung; Yu, Wing Yiu; Fan, Qinghua; Chan, Albert S. C. researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).SDS of cas: 221012-82-4.They published the article 《Asymmetric hydrogenation of quinolines with recyclable and air-stable iridium catalyst systems》 about this compound( cas:221012-82-4 ) in Tetrahedron: Asymmetry. Keywords: quinoline asym hydrogenation recyclable iridium catalyst; tetrahydroquinoline alkyl asym synthesis. We’ll tell you more about this compound (cas:221012-82-4).

The iridium complex-catalyzed asym. hydrogenation of quinolines in a poly(ethylene glycol) di-Me ether (DMPEG)/hexane biphasic system was studied. Catalysts with C2-sym. ligands such as Xyl-P-Phos, Cl-MeO-BIPHEP, SYNPHOS, and DifluorPhos are highly effective for this type of reaction. Most of the catalysts tested can be retained in DMPEG (Mn = 500), and the asym. hydrogenation of various quinoline substrates can be carried out in DMPEG/hexane biphasic system with up to 92% ee. The catalysts and the products can be separated via simple phase separation, and the reactivity/stereoselectivity of the catalysts can be retained for at least three reaction cycles.

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Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Pd-catalyzed asymmetric alternating co-polymerization of propene with carbon monoxide using ionic liquids. Author is Wang, Hai-Jun; Wang, Lai-Lai; Lam, Wing-Sze; Yu, Wing-Yiu; Chan, Albert S. C..

A protocol for Pd-catalyzed stereoselective co-polymerization of propene and carbon monoxide using chiral ligands, such as (2S,3S)-DIOP and (R)-P-Phos in [C4mim][PF6]/[C6mim][PF6] as an ionic liquid medium was developed. With (2S,3S)-DIOP as chiral ligand and [C4mim][PF6] as medium, the Pd-catalyzed co-polymerization of propene and CO gave almost completely regioregular polyketones, and the product polymer showed moderate stereoregularity (61% of l-diads). The highest molar optical rotation = +15.9 and polydispersity = 1.2 were attained when (R)-P-Phos was used as the ligand and [C6mim]PF6 as the solvent. The co-polymer exhibited regioregularity of H-H/H-T/T-T (%) = 17:66:17.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider