Category: 221012-82-4

Xing, Ai-ping; Wang, Lai-lai; Kwok, Waihim published the article 《Asymmetric amidocarbonylation of aldehyde and acetamide catalyzed by chiral palladium or rhodium complexes》. Keywords: chiral palladium rhodium catalyst asym amidocarbonylation aldehyde acetamide.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).SDS of cas: 221012-82-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.

The in situ prepared chiral catalyst of Pd/unchelating bidentate phosphine ligand L1 (DPPFF), bipyridine bidentate phosphine ligand L2 (P-PHOS), and bidentate phosphine ligand L3 ((S, Rp) -BPPF), and Rh/phosphite ligands L4-L6, have been applied in amidocarbonylation of cyclohexanecarboxaldehyde or phenylacetaldehyde. Pd/bipyridine bidentate phosphine ligand L2 gave the enantioselectivity 25% (S) and the yield 11% in amidocarbonylation of phenylacetaldehyde, When Pd/unchelating bidentate phosphine ligand L1 was employed in asym. amidocarbonylation of cyclohexanecarboxaldehyde, the enantioselectivity 4.3% (S) and the yield 15% were received.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Delineating Origins of Stereocontrol in Asymmetric Pd-Catalyzed α-Hydroxylation of 1,3-Ketoesters.Product Details of 221012-82-4.

Systematic studies of reaction conditions and subsequent optimization led to the identification of important parameters for stereoselectivity in the asym. α-hydroxylation reaction of 1,3-ketoesters. Enantioselectivities of up to 98% can be achieved for cyclic substrates and 88% for acyclic ketoesters. Subsequently, the combination of cyclic/acyclic ketoester, catalyst, and oxidant was found to have a profound effect on reaction rates and turnover-limiting steps. The stereochem. of the reaction contradicts that observed for other similar electrophilic substitution reactions. This was rationalized by transition-state modeling, which revealed a number of cooperative weak interactions between oxidant, ligand, and counterion, together with C-H/π interactions that cumulatively account for the unusual stereoselectivity.

Although many compounds look similar to this compound(221012-82-4)Product Details of 221012-82-4, numerous studies have shown that this compound(SMILES:COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Fujimoto, Hayato; Kusano, Momoka; Kodama, Takuya; Tobisu, Mamoru published an article about the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4,SMILESS:COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6 ).Quality Control of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:221012-82-4) through the article.

The Ni-catalyzed cyclization of bisphosphine derivatives to form various phosphacycles is reported. The reaction proceeds via the cleavage of two C-P bonds of the bisphosphine. Unlike the previously reported Pd catalysts, the use of Ni as a catalyst allows for the cyclization that requires C(alkyl)-P bond cleavage. A phospha-nickelacycle intermediate was successfully isolated and characterized by x-ray crystallog.

Although many compounds look similar to this compound(221012-82-4)Quality Control of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, numerous studies have shown that this compound(SMILES:COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Polyethylene glycol as an environmentally friendly and recyclable reaction medium for enantioselective hydrogenation.Recommanded Product: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

Polyethylene glycol (PEG) was found to be an inexpensive, non-toxic and recyclable reaction medium for ruthenium- and rhodium-catalyzed asym. hydrogenation of 2-arylacrylic acids (Ru-catalyzed C=C bond reduction), enamides (Rh-catalyzed C=C bond reduction), β-keto esters and simple aromatic ketones (Ru-catalyzed C=O bond reduction). In all cases, high catalytic activities and enantioselectivities have been achieved, which are comparable to those obtained in conventional organic solvent systems. The Ru and Rh catalysts prepared with com. available chiral diphosphine ligands could be readily recycled by simple extraction, as in the case of ionic liquids, and reused up to nine times without obvious loss of catalytic activity and enantioselectivity. The reduced products were obtained from the extracts in high isolated yields. These results indicate that PEGs as new reaction media are attractive alternatives to room temperature ionic liquids

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates. Author is Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine.

For the first time, the asym. hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands. Accelerated examination of ligands and catalysts has been undertaken by using a Chemspeed workstation (automated instrument) workstation enables carrying out, in parallel, eight independent catalytic reactions at the laboratory scale. Tetrahydroquinoxaline-2-carboxylates could be obtained with high yields and up to 74% ee. The synthesis of the target compounds was achieved using chiral ligands, such as (11aR)-10,11,12,13-tetrahydro-N,N-dimethyldiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin-5-amine [i/e/. (R)-siphos], 1,1′-[(1S)-6,6′-dimethoxy[1,1′-biphenyl]-2,2′-diyl]bis[1,1-diphenylphosphine] [i.e., (S)-MeO-BIPHEP], (R)-Cl-MeO-BIPHEP, (R)-difluorphos, (R)-GARPHOS, (R)-P-PHOS, (S)-C3-TUNEPHOS [i.e., 1,1′-[(13aS)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin-1,13-diyl]bis[1,1-diphenylphosphine]], (S)-SEGPHOS, (S)-Xyl-SolPhos, CATASium T3, N-[(1R)-2-[(11bR)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yloxy]-1-methylethyl]-N’-phenylurea [i.e., ureaphos], SL-J404-1, SL-J006-1, SL-J002-1, SL-J003-1, SL-J009-1, SL-T002-1, SL-W006-1. Pre-catalysts included bis(acetato-κO,κO’)[(4R)-1,1′-[4,4′-bi-1,3-benzodioxole]-5,5′-diylbis[1,1-diphenylphosphine-κP]]ruthenium [i.e., Ru(OAc)2[(R)-segphos]], [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium [i.e., RuCl[(R,R)-TsDPEN][p-cymene]] and [1,1′-(1S)-[4,4′-bi-1,3-benzodioxole]-5,5′-diylbis[1,1-diphenylphosphine-κP]][4-cyano-3-nitrobenzenecarboxylato(2-)-κC6,κO1](η3-2-propen-1-yl)iridium.

Compounds in my other articles are similar to this one((R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine)Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 221012-82-4, is researched, Molecular C38H34N2O4P2, about One-step synthesis of chiral dimethyl 2-oxo-3-phenyl-glutarate in the asymmetric triple-carbonylation of styrene, the main research direction is styrene carbon monoxide palladium chiral PHOS enantioselective triple carbonylation; dimethyl oxophenylglutarate stereoselective preparation; carbonylation catalyst palladium chiral PHOS.Recommanded Product: 221012-82-4.

One-step synthesis of chiral di-Me 2-oxo-3-phenyl-glutarate via asym. triple-carbonylation of styrene catalyzed by palladium complex with chiral 2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphine)-3,3′-bipyridine is reported.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Name: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Nickel-catalyzed enantioselective allylic alkylation of lactones and lactams with unactivated allylic alcohols. Author is Ngamnithiporn, Aurapat; Jette, Carina I.; Bachman, Shoshana; Virgil, Scott C.; Stoltz, Brian M..

The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver α-quaternary lactones and lactams bearing an all-carbon quaternary stereocenter I [X = O, N-Bz, R1 = Me, Et; R2 = H, Ph, 2-furanyl, etc.] was reported. The reaction, which utilize a com. available chiral bisphosphine ligand, proceeded in good yield with a high level of enantioselectivity (up to 90% ee) on a range of unactivated allylic alcs. for both lactone and lactam nucleophiles. The utility of this method was further highlighted via a number of synthetically useful product transformations.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 221012-82-4, is researched, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2Journal, Cuihua Xuebao called One-step synthesis of chiral dimethyl 2-oxo-3-phenyl-glutarate in the asymmetric triple-carbonylation of styrene, Author is Wang, Lailai; Zhang, Qinsheng; Cui, Yuming, the main research direction is styrene carbon monoxide palladium chiral PHOS enantioselective triple carbonylation; dimethyl oxophenylglutarate stereoselective preparation; carbonylation catalyst palladium chiral PHOS.Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

One-step synthesis of chiral di-Me 2-oxo-3-phenyl-glutarate via asym. triple-carbonylation of styrene catalyzed by palladium complex with chiral 2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphine)-3,3′-bipyridine is reported.

Compounds in my other articles are similar to this one((R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine)Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 221012-82-4, is researched, Molecular C38H34N2O4P2, about Extensive re-investigations of pressure effects in rhodium-catalyzed asymmetric hydrogenations, the main research direction is pressure effect rhodium catalysis asym hydrogenation.Reference of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

The catalytic hydrogenation of three prochiral substrates Me Z-α-acetamidocinnamate (MAC), Me 2-acetamidoacrylate (M-Acrylate) and Et 4-methyl-3-acetamido-2-propanoate (E-EMAP) with rhodium precursors complexed with chiral diphosphines is reported at 1-30 bar hydrogen pressure. A library of 56 chiral diphosphines, including 23 BINAP derivatives, 7 JOSIPHOS, 5 BIPHEP, 3 DUPHOS derivatives, and 18 other ligands, was used. While it was generally accepted that high hydrogen pressure would result in lower ees, it is now demonstrated on a statistical basis that an equivalent distribution between beneficial and detrimental pressure effects on ee prevails and that the hydrogen pressure effect on enantioselectivity is not an isolated phenomenon since more than 33% of the reaction systems studied are strongly affected. In some case, the enantioselectivity can be improved up to 97% just by applying a higher hydrogen pressure. Extension of these conclusions to other non-chiral reagents is proposed.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Product Details of 221012-82-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Nickel-catalyzed asymmetric α-arylation of ketone enolates. Author is Chen, Guoshu; Kwong, Fuk Yee; Chan, Hoi On; Yu, Wing-Yiu; Chan, Albert S. C..

An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates, generated in situ from 1-benzoalkanones, such as 2-methyl-1-tetralone, 2-methyl-1-indanone or 2-methylbenzosuberone, with aryl halides RX (R = Ph, X = Cl, Br, iodo; R = 4-NCC6H4, 4-F3CC6H4, 4-Me3CC6H4, etc., X = Br) to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider