Category: 221012-82-4

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tang, Wei-Jun; Zhu, Shou-Fei; Xu, Li-Jin; Zhou, Qi-Lin; Fan, Qing-Hua; Zhou, Hai-Feng; Lam, Kimhung; Chan, Albert S. C. researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Formula: C38H34N2O4P2.They published the article 《Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio》 about this compound( cas:221012-82-4 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: quinoline alkyl asym hydrogenation iridium spiro diphosphinite; tetrahydroquinoline asym synthesis. We’ll tell you more about this compound (cas:221012-82-4).

The chiral diphosphinite ligand derived from (R)-1,1′-spirobiindane-7,7′-diol has been found to be highly effective in the Ir-catalyzed asym. hydrogenation of quinolines with high substrate/catalyst ratio (up to 5000) and high enantioselectivity (up to 94% ee).

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Maj, Anna M.; Suisse, Isabelle; Hardouin, Christophe; Agbossou-Niedercorn, Francine published the article 《Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines》. Keywords: quinoline cyclooctadiene iridium chloride chiral bisphosphine ligand iodine hydrogenation; tetrahydroquinoline stereoselective preparation.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Application of 221012-82-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.

The asym. hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.

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Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Construction of Acyclic Quaternary Carbon Stereocenters by Catalytic Asymmetric Hydroalkynylation of Unactivated Alkenes.

Quaternary carbon stereocenters are common structural motifs in organic synthesis. The construction of these stereocenters in a catalytic and enantioselective manner remains a prominent synthetic challenge. In particular, methods for the synthesis of alkyne-substituted quaternary carbon stereocenters are very rare. Previous catalytic systems for hydroalkynylation of alkenes create tertiary stereocenters. An iridium catalyzed asym. hydroalkynylation of nonactivated trisubstituted alkene is described. The hydroalkynylation of β,γ-unsaturated amides occurs with high regio- and enantioselectivities to afford alkyne-substituted acyclic quaternary carbon stereocenters. Computational and exptl. data suggest that the enantioselectivity is not only determined by the facial selectivity of the alkene but also by an alkene isomerization process. This strategy provides an efficient method to access alkyne-substituted acyclic quaternary carbon stereocenters with minimally functionalized starting materials.

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Quinoxaline – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine(SMILESS: COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6,cas:221012-82-4) is researched.Application In Synthesis of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. The article 《Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of (R)-Tolterodine》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:221012-82-4).

Rhodium-catalyzed asym. 1,4-addition of arylboronic acids R1B(OH)2 (R1 = Ph, 4-MeC6H4, 3-MeC6H4, 4-ClC6H44, 4-MeOC6H4) to coumarins I (R = 6-Me, H, 6-MeO2C, 8-MeO) proceeded with high enantioselectivity in the presence of a rhodium catalyst (3 mol %) generated from Rh(acac)(C2H4)2 and (R)-Segphos to give the corresponding (R)-4-arylchroman-2-ones II in over 99% ee. This asym. reaction was applied to the synthesis of (R)-tolterodine.

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Quinoxaline – Wikipedia,
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Grasa, Gabriela A.; Zanotti-Gerosa, Antonio; Hems, William P. published the article 《A chiral [(dipyridylphosphine)RuCl2(1,3-diphenylpropanediamine)] catalyst for the hydrogenation of aromatic ketones》. Keywords: hydrogenation transfer stereoselective ruthenium catalyst preparation ketone; phenylphosphine bipyridine ruthenium propanediamine preparation transfer hydrogenation catalyst; asym synthesis phenylphosphine bipyridine ruthenium propanediamine preparation.They researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).Name: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:221012-82-4) here.

The use of chiral (+)-(S,S)-1,3-Diphenyl-1,3-propanediamine in combination with Ru-Xyl-P-Phos, gave up to 95% ee in the hydrogenation of acetophenone. Thus, [(3R)-4,4′-bis[bis(3,5-dimethylphenyl)phosphine]-2,2′,6,6′-tetramethoxy-3,3′-bipyridine]dichloro[(1S,3S)-1,3-diphenyl-1,3-propanediamine]ruthenium was prepared and its catalytic activity and selectivity were compared with its corresponding stereoisomers.

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Quinoxaline – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Enantioselective Allylation, Crotylation, and Reverse Prenylation of Substituted Isatins: Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation, the main research direction is benzylisatin stereoselective preparation mechanism; isatin allylacetate allene allylation crotylation prenylation; alkylation transfer hydrogenation iridium catalyst isopropanol.HPLC of Formula: 221012-82-4.

The first examples of enantioselective catalytic allylations, crotylations, and reverse prenylations of isatin are reported. Unlike conventional allylation methodologies, they have been achieved by isopropanol-mediated transfer hydrogenation without the use of stoichiometric amounts of allylmetal reagents. Activated ketones in the form of substituted isatins were subjected to highly enantioselective carbonyl allylation, crotylation, and reverse prenylation, constituting a convenient synthesis of optically enriched 3-substituted 3-hydroxy-oxindoles, e.g. I.

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Recommanded Product: 221012-82-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Highly effective chiral dipyridylphosphine ligands: Synthesis, structural determination, and applications in the Ru-catalyzed asymmetric hydrogenation reactions. Author is Barbara, Pierluigi; Bianchini, Claudio.

The synthesis of the new heteroaromatic chiral diphosphine ligands (R) and (S)-(P-phos) [P- phos = 2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine] was carried out by a standard synthetic protocol ending up with an Ullmann coupling, followed by resolution of the racemic product. The ligands display an axial chirality due to atropisomery-, analogous to that observed in the parent ligand MeO-BIPHEP. Well-defined ruthenium(II) catalysts were prepared and employed to catalyze the hydrogenation of a prochiral olefins of pharmaceutical relevance and various β-ketoesters.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 221012-82-4, is researched, Molecular C38H34N2O4P2, about Multicomponent Cyclopropane Synthesis Enabled by Cu-Catalyzed Cyclopropene Carbometalation with Organoboron Reagent: Enantioselective Modular Access to Polysubstituted 2-Arylcyclopropylamines, the main research direction is enantioselective multicomponent synthesis arylcyclopropylamine; copper catalyzed cyclopropene carbometalation organoboron reagent.Related Products of 221012-82-4.

The use of functional-group-tolerant organoboron in lieu of basic organometallic reagents in base-metal-catalyzed cyclopropene carbometalation opens three-component cyclopropane synthesis, as exemplified by the modular assembly of the highly medicinally relevant 2-arylcyclopropylamine (ACPA) framework via stereoselective carboamination. The highly enantioselective version has been realized to afford enantioenriched ACPAs with up to all three cyclopropyl carbons as stereogenic centers in one operation, representing the first example of enantioselective multicomponent cyclopropane synthesis. The reaction significantly improves the efficiency of ACPA synthesis and may inspire the development of other multicomponent cyclopropane syntheses beyond amination.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 221012-82-4, is researched, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2Journal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Application of Copper(II)-Dipyridylphosphine Catalyst in the Asymmetric Hydrosilylation of Simple Ketones in Air, Author is Zhang, Xi-Chang; Wu, Yan; Yu, Feng; Wu, Fei-Fei; Wu, Jing; Chan, Albert S. C., the main research direction is ketone hydrosilylation copper pyridylphosphine catalyst; secondary alc asym preparation.Reference of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine.

A copper(II) salt/chiral dipyridylphosphine/PhSiH3 system (see scheme) acts as a very effective and practical catalyst for the asym. reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94 %), giving many chiral alcs. that are intermediates for physiol. active compounds Remarkable temperature effects were observed for some heteroaromatic ketones.

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Recommanded Product: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Asymmetric hydrogenation of isobutyrophenone Using a [(diphosphine)RuCl2(1,4-diamine)] catalyst. Author is Grasa, Gabriela A.; Zanotti-Gerosa, Antonio; Medlock, Jonathan A.; Hems, William P..

The use of three chiral 1,4-diamines in the [(diphosphine)RuCl2(diamine)] catalyst system is demonstrated in the hydrogenation of acetophenone. The use of a 1,4-diamine offers unique properties that allow tuning of the catalyst system. These include the 1st example of the use of a racemic diamine in combination with a chiral phosphine, which gives 95% ee in the hydrogenation of isobutyrophenone.

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Quinoxaline – Wikipedia,
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