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In an effort to develop potent antiamoebic agents, we have synthesized chalcones (1-8), amino-5-substituted-(3-phenyl(2-pyrazolinyl))methane-1-thione derivatives (1a-8a) and 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives (1b-8b) and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of E. histolytica. All the compounds were characterized by electronic, IR, 1H NMR and mass spectroscopic data. It was observed that the antiamoebic activity enhances on modifying the structure of chalcones to the pyrazolines and further to quinoxalines. The MTT assay was performed on human kidney epithelial cell line to check the cytotoxicity of the compounds and the results were compared with metronidazole. Compound 6b showed better antiamoebic activity and less toxicity than metronidazole.

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The ‘proton sponge’ – triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series.

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A PdII-catalyzed 2:1 coupling reaction of alkynylbenziodoxole with carboxylic acid to afford (alk-1-en-3-ynyl)benziodoxole, which is efficiently promoted by an octahydrophenazine ligand, is reported. The reaction involves a Pd-assisted 1,2-iodine(III) shift of the alkynylbenziodoxole followed by stereoselective introduction of carboxy and alkynyl groups (the latter originating from another molecule of the alkynylbenziodoxole) into the 1-position of the transient Pd-vinylidene species. The product of this 1,1-carboxyalkynylation reaction serves as a new functionalized enyne-type building block for further synthetic transformations.

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A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallographic studies of the compound.

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The present invention relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By using the organic electroluminescent compound according to the present invention, it is possible to produce an organic electroluminescent device having low driving voltage, excellent current and power efficiencies, and noticeably improved driving lifespan.

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A new P-chiral phosphine ligand, (R,R)-2,3-bis(tert-butylmethylphosphino)quinoxaline, has been prepared by the reaction of enantiomerically pure tert-butylmethylphosphine-borane with 2,3-dichloroquinoxaline. This ligand, in contrast to most of the previously reported P-chiral ligands, is an air-stable solid and exhibits excellent enantioselectivities in both Rh-catalyzed asymmetric hydrogenations and Rh- or Pd-catalyzed carbon-carbon bond-forming reactions. Copyright

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The title compound, C34H22N4O4, results from the reaction of 2,3,6,7-tetrahydroxy-9,10-dimethyl-9,10-dihydro-9, 10-ethanoanthracene with 2,3-dichloroquinoxaline. The molecule, which contains a binary crystallographic symmetry axis, comprises two planar ‘wings’ around a central bicyclic unit. The non-ideal geometry of the latter evidences some strain, as in previous compounds with the same central core. Each molecule is involved in pi-pi interactions with four of its neighbours, oriented upside-down, which results in the formation of sheets of tightly packed molecules.

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Condensation of 4-amino-5-mercapto-3-(m-methylphenyl)-s-triazole 1 with cyanogen bromide gives 6-amino-3-(m-methylphenyl)-s-triazolo[3,4-b]-1,3,4-thiadiazole 2 which on condensation with chloranil yields 3.9-di-(m-methylphenyl)-6,14-diaxo-bis-(s-triazolo[3,4-b]-1,3,4-thiadiazolo[3, 2-b][imidazo[4.5-b]cyclohexane]-5a. 6a-diene) 3. 3-(m-Methylphenyl)-s-triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b] quinoxaline 4 is obtained by a similar condensation of 2 with 2,3-dichloroquinoxaline. The reaction of 2 with alpha-haloketones followed by bromination affords 7-aryl-3-(m-methylphenyl) imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles 5 and their 6-bromo analogues 6 respectively. The antibacterial and antifungal activities of some of the compounds have also been evaluated.

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The sublevel phosphorescence spectra of quinoxaline and 2,3-dichloroquinoxaline are obtained in a light atom host such as naphthalene-d8 and 1,2,4,5,-tetramethylbenzene and in a heavy atom host such as 1,2,4,5,-tetrabromobenzene.Only the radiative decays, but not the nonradiative decays, are susceptibile to external heavy atom effect.For the phosphorescence from the in-plane sublevels significant heavy atom effect is observed for the 0-0 and some vibronic bands involving nontotally symmetric vibrations.For the phosphorescence from the out-of-plane sublevel, external heavy atom effect exists but the enhancement is very slight.These features are interpreted satisfactorily in the framework of a theory.The external heavy atom effect observed in 1,4-dibromobenzene differs sonsiderably, and the origin of the discrepancy is discussed.

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Condensation of 4-amino-5-mercapto-3-p-(t-butylphenyl)-s-triazole 1 with cyanogen bromide gives 6-amino-3-p-(tbutylphenyl)-s-triazolo[3,4-b][1,3,4]thiadiazole 2 which on condensation of with chloranil yields 3,9-di-p-(t-butylphenyl)6,14-dioxo-bis-(s-triazolo[3,4-b] [1,3,4]thiadiazolo[3,2-b]-[imidazo[4,5-b]cyclohexane]-5a,6a-diene) 3. 3-p-(t-Butylphenyl)s-triazolo[3,4-b][1,3,4]thiadiazolo[3,2-b]-imidazo [4,5-b] quinoxaline 4 is obtained by a similar condensation of 2 with 2,3-dichloroquinoxaline. The reaction of 2 with alpha-haloketones followed by bromination affords 7-aryl-3-p-(t-butylphenyl)imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles 5 and their 6-bromo analogues 6 respectively. The antibacterial and anti-fungal activities of some of the compounds have also been evaluated.

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Quinoxaline – Wikipedia,
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