New explortion of 2,3-Dichloroquinoxaline

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2,3-Dichloroquinoxaline when treated with the multi-sulphur dithiolate (1) gave the thione (2), which was coupled using neat triethyl phosphite to give the bisquinoxalinodithiin-fused tetrathiafulvalene, BQDT-TTF (3).Cross coupling of thione (2) with 4,5-bis(methylthio)-1,3-dithiole-2-thione and 5,6-dihydro-1,3-dithio<4,5-b><1,4>dithiin-2-thione afforded the unsymmetrical donors (4) and (5) respectively.The oxidation potentials of donors (4) and (5) are reported along with the preparation and electrical conductivity measurement of a tri-iodide cation-radical salt of BQDT-TTF (3).

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New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.Application of 2213-63-0, In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Several [1,2,4]triazolo[4,3-a]quinoxalines that were reported as antidepressants in the patent literature were found to possess moderate affinity for the adenosine A1 and A2 receptors. On the basis of structural parallels with adenine and adenosine, the N-cyclopentyl derivative was synthesized and found to have improved affinity and selectivity for the A1 receptor. In the N-cyclopentyl series, affinity was optimal with trifluoromethyl substitution at the 1-position, resulting in a compound (9) with 7.3 nM A1 affinity and 138-fold selectivity for the A1 receptor.

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Cyclocondensation of 2,3-dichloroquinoxaline (4) and the 2-aminothiophenols 1a-h or their zinc mercaptides 3a-h in the presence of alkaline dimethylformamide or in acidic medium afforded the corresponding 12H-quinoxalino<2,3-b><1,4>benzothiazines 7a-h in excellent yields.Similarly, the reaction of 4 with substituted 2-aminophenols 2 in the presence of base using dimethylformamide as solvent gave the 12H-quinoxalino<2,3-b><1,4>benzoxazines 7i-k.Acetyl derivatives of 7a-k were prepared.

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Phenylalanine derivatives of formula (1) are described: in which:Ar1 is an aromatic or heteroaromatic group;L1 is a linker atom or group;R is a carboxylic acid or a derivative thereof;Ar2 is an optionally substituted aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of a4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

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An optically active 2,3-bis(dialkylphosphino)pyrazine derivative represented by formula (1) is disclosed. The pyrazine derivative is preferably a quinoxaline derivative represented by formula (2). In formula (1) and (2), R1 is preferably a t-butyl or adamantyl group, and R2 is preferably a methyl group. wherein R1 is a substituted or unsubstituted, straight chain or branched alkyl group having 2 to 10 carbon atoms; R2 is a substituted or unsubstituted, straight chain or branched alkyl group having fewer carbon atoms than R1; and R3 and R4, which may be the same or different, are each a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or R3 and R4 are taken together to form a saturated or unsaturated ring. wherein R1 and R2 are as defined above; and R5 is a monovalent substituent.

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Abstract: Synthesis of 2,3-disubstituted 1-alkylpyrrolo[2,3-b]quinoxalines was accomplished through the reaction of 3-chloroquinoxalin-2-amines with internal alkynes in the presence of Pd(OAc)2, NaOAc, and KOtBu in DMSO. This method afforded desired pyrrolo[2,3-b]quinoxalines in 65?92% reaction yields. The minimum inhibition concentration and minimum bactericidal concentration determinations against Micrococcus luteus and Pseudomonas aeruginosa revealed that some of the synthesized compounds showed the same values compared to tetracycline. These compounds could be used in the future research for the development of new antibiotics. Graphical Abstract: [Figure not available: see fulltext.].

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2213-63-0 is helpful to your research. Electric Literature of 2213-63-0

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The present invention provides an excellent solubility, it has high anticancer property and has low toxicity posture anti-cancer agent. Anticancer agent of the present invention is characterized in that the composition of: containing the following formula (1) of the said phosphine transition metal complex and a cyclodextrin compound. [Process 1] (In the formula, R 1 and R 2 shows straight-chain or branched alkyl, cycloalkyl, with substituent cycloalkyl, adamantyl, phenyl or phenyl with substituent, the carbon number is 1-10, the group can be the same, can also be a different group. R 3 and R 4 represents a hydrogen atom or straight-chain or branched alkyl group, the carbon number is 1-6, the group can be the same, can also be a different group. R 3 and R 4 can also be bonded to each other to form a saturated or unsaturated ring, the saturated or unsaturated ring can also be provided with a substituent. elects from the gold M said, copper and silver of transition metal atom of the group. X – represents an anion). (by machine translation)

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Compounds of the general formula (I):wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT 2 receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2 c receptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.

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The emission and excitation spectra of quinoline and 2,3-dichloroquinoxaline embedded in a calcinated (600 deg C) porous Vycor glass and dissolved in fluid solutions were recorded at various temperatures.The spectral characteristics and phosphorescence lifetimes of adsorbates were observed to be identical with those in 0.5 N H2SO4 solutions, indicating that H+ is transferred from the surface to the N-hetrocyclics.The strong surface-adsorbate interaction is futher revealed by the dynamic study of adsorbates at 77 and 4.2 K.

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Various oxepine and azepine fused N-heterocyclic derivatives were synthesized using a new and one-pot reaction of 2,3-dichloro quinoxaline/pyrazine with 2-(1H-indol-2-yl)phenol/aniline in the presence of 25 mol% FeCl3. The reaction proceeded via C-C bond followed by C-X (X = O or N) bond formation to construct the central 7-membered ring, affording the desired products in good yields. The structure assignment was confirmed by the single crystal X-ray analysis of a synthesized oxepine fused N-heterocycle derivative. Most of the synthesized compounds were found to be promising when tested for their anti-proliferative properties against cervical and breast cancer cell lines.

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