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In order to further understand the mechanism details during saline wastewater treatment by ?OH-based advanced oxidation processes (AOPs), the degradation efficiency of an azo dye Acid Orange 7 (AO7) in UV/H2O2 process was investigated as a function of a wide range of salinity and pH. Kinetic modeling results demonstrated that the inhibitory effect of Cl- on AO7 degradation observed in the laboratory experiments could be attributed to both scavenging effect of Cl- on ?OH and the much lower reactivity of chlorine radicals formed, although the chlorine radicals may be more abundant than ?OH. Such retardation behavior was favored under acidic conditions due to a lower yield of ?OH generated by the dissociation of ClOH?- to ?OH and Cl-. Traces of Br- had a greater inhibitory effect on AO7 bleaching rate than Cl-. AOX (halogenated organic compounds adsorbable on activated carbon) was found to increase with the increasing content of Cl-. Based on the intermediate products and especially several toxic halogenated byproducts identified by GC-MS, the possible degradation pathways of saline dyeing wastewater were proposed.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1610 | ChemSpider

 

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New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2213-63-0, name is 2,3-Dichloroquinoxaline, introducing its new discovery. Electric Literature of 2213-63-0

Oligomers of human islet amyloid polypeptide (h-IAPP) are believed to be the pathogenic species for type 2 diabetes mellitus. Peptide-cleaving agents selective for oligomers of h-IAPP were synthesized by using quinoxaline derivatives as recognition sites attached to the Co(III) complex of cyclen in this study. When the initial concentration of h-IAPP was lowered from 4.0 to 0.20 lM cleavage yield of the new agents was enhanced by 3 times reaching 16-22 mol %. This shows that the agents would have significant activities at subnano molar concentrations if the concentration of h-IAPP is lowered to the in vivo values. This further indicates that the peptide-cleaving agents prepared previously in this laboratory possess sufficiently high activity for application as a new therapeutic option for Alzheimer’s disease, type 2 diabetes mellitus, and Parkinson’s disease.

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Quinoxaline | C8H6N1291 | ChemSpider

 

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Resorcinarene-based deep cavitands alanine methyl resorcinarene acid (AMA), alanine undecyl resorcinarene acid (AUA) and glycine undecyl resorcinarene acid (GUA), which contain chiral amino acids, have been synthesized. The upper rim of the resorcinarene host is elongated with four identical substituents topped with alanine and glycine groups. The structures of the new resorcinarenes were elucidated by nuclear magnetic resonance (NMR), mass spectrometry (MS) and the sustained off-resonance irradiation collision induced dissociation (SORI-CID) technique in FTICR-MS. These studies revealed that eight water molecules associate to the cavitand, two for each alanine group. The alanine substituent groups are proposed to form a kite-like structure around the resorcinarene scaffold. The binding of AMA, AUA, and GUA with chiral R- and S-methyl benzyl amines was studied by 1H NMR titration, and compared to that of a binary l-tartaric acid and the monoacid phthalyl alanine (PA). The results show that these compounds interact with amine guests; however, with four carboxylic acid groups, they bind several amine molecules strongly while the binary l-tartaric acid only binds one amine guest strongly. The simple compound PA, which contains one carboxylic group, shows weak binding to the amines. The 1H NMR titration of AUA with primary, secondary, and tertiary chiral amines showed that it can discriminate between these three types of amines and showed chiral discrimination for chiral secondary amines.

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Quinoxaline – Wikipedia,
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name: 2,3-Dichloroquinoxaline, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a article,once mentioned of 2213-63-0

The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 wt % 4-dimethylaminopyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale.

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Starting from 2,3-dichloroquinoxaline, a synthetic strategy for the preparation of 1-(3-phenylpropyl)-4-(pyridinylmethoxy)[1,2,4]triazolo[4,3-a]quinoxalines is described.

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Quinoxaline – Wikipedia,
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An inherently chiral ABii diphosphonato cavitand (±)-4 bearing a single quinoxaline bridging moiety was synthesized and resolved by chiral HPLC. Its chiroptical properties were investigated and VCD experiments allowed the determination of its absolute configuration. Distinguishable diastereomeric complexes in solution with l-adrenaline were observed by 1H and 31P NMR together with a noticeable enantio-discrimination at 253 K (dr ?2:1) in favor of the dextrorotatory cavitand (+)-4.

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Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.

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Quinoxaline – Wikipedia,
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The specification includes a number including novel compounds and organic light emitting […] substrate. (by machine translation)

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Reference:
Quinoxaline – Wikipedia,
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A synthesis of novel hexacyclic bis-benzimidazoles 6 starting from 2,3-diarylamino-quinoxalines via an oxidative cyclization cascade is described. These very stable and high-melting derivatives are featured by their strong fluorescence in the blue region of the visible spectrum. The cyclization reaction between 2,3-dichloroquinoxaline and 1,2-phenylenediamine did not lead to derivatives of type 6. In this case, only fluoflavine 7 was isolated quantitatively.

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Reference:
Quinoxaline – Wikipedia,
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Condensation reactions of N’-phenylbenzohydrazide, N’-phenylbenzothiohydrazide, and dithizone with a variety of activated aromatic and heteroaromatic 1,2-dihalogeno and 1-halogeno-2-nitro compounds are described in which the hydrazide or thiohydrazide functions as a bidentate nucleophile.These reactions lead to derivatives of the 4H-1,3,4-benzoxadiazines and 4H-1,3,4-benzothiadiazines and analogous pyrimido-, pyrazino-, and quinoxalinooxadiazines and -thiadiazines which are representative of new ring systems.The corresponding reaction of N’-phenylbenzothiohydrazide with chloranil proceeds with expulsion of sulfur.The mechanism of this reaction is discussed.

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Quinoxaline – Wikipedia,
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