Archives for Chemistry Experiments of 2,3-Dichloroquinoxaline

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Oligoacenes are of interest as organic p-type semiconductors for use in electronic devices, but their use as n-type semiconductors is limited. N-Heteroacenes have been investigated as oligoacene-based n-type semiconductors due to their enhanced electron affinity. Herein, we report the synthesis, X-ray crystal structures, electrochemical, and field-effect transistor properties of TANC and BTANC.

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The synthesis of various 2,4-disubstituted 4H-1,3,4-thiadiazino-[5,6-b] quinoxalines via reaction of hydrazonoyl halides with 2-amino-3-quinoxalinethiol in ethanol in the presence of sodium ethoxide is described. The structures of the reaction products were elucidated by chemical evidence and by their IR, 1H, 13C-NMR, and MS spectra. The mechanism of the formation of the products is also discussed. Copyright Taylor & Francis Inc.

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Quinoxaline-bridged bidentate bis-imidazolium dicarbene ligand 1,1?-(quinoxaline-2,3-diyl)bis(3-methyl-1H-imidazol-3-ium) hexafluorophosphate salt H2L·2PF6 (3) was prepared by a two-step reaction based on 2,3-bis(imidazol-1-yl)quinoxaline (1). First, the 2,3-bis(imidazol-1-yl)quinoxaline reacted with CH3I resulting in the 1,1?-(quinoxaline-2,3-diyl)bis(3-methyl-1H-imidazol-3-ium) iodide salt H2L·2I (2), then through anion exchange reactions with NH4PF6 in water produced the desired bis-imidazolium bidentate ligand H2L·2PF6 (3). Reaction of the bidentate bis-imidazolium ligands H2L·2PF6 (3) with Ag2O in acetonitrile gave the macrocyclic binuclear silver(I) carbene complex [Ag2(L)2]·2PF6·CH3CN (4). Nickel carbene complex [Ni(L)PPh3Cl]·PF6·2DMSO (5) was obtained via transmetalation of 4 with Ni(PPh3)2Cl2 in DMSO. The bidentate carbene ligand is a chelating ligand in 5, while bridging in 4. The imidazolium ligand H2L·2PF6 (3) and transition metal carbene complexes 4 and 5 have been fully characterized by elemental analysis, NMR, ESI-MS spectroscopy, and X-ray diffraction analyses. Furthermore, the UV and luminescent properties of 3?5 were also studied.

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New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2213-63-0, name is 2,3-Dichloroquinoxaline, introducing its new discovery. COA of Formula: C8H4Cl2N2

1,4-Disubstituted pyrrolo[1,2-a]quinoxalines were prepared through the one-pot multi-component reactions of 3-substituted-2-chloroquinoxalines, propargyl alcohol, and secondary amines, catalyzed by Pd/Cu, in the presence of K2CO3and sodium dodecyl sulfate (SDS) in water. This process provided a facile, eco-friendly, and highly efficient method for the synthesis of new pyrrolo[1,2-a]quinoxalines in water with good yields.

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The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated against three tumor cell lines (HCT116 human colon carcinoma, HepG2, liver hepatocellular carcinoma and MCF-7, human breast adenocarcinoma cell line), in addition to VEGFR-2 enzyme inhibition activity. Compounds VIId, VIIIa, VIIIc, VIIIe and XVa exhibited promising activity against the tested cell lines and weak activity against VEGFR-2. Compound VIIIc induced a significant disruption in the cell cycle profile and cell cycle arrest at the G2/M phase boundary. In further assays, the cytotoxic effect of the highly active compounds was determined using a normal Caucasian fibroblast-like fetal lung cell line (WI-38). Compound VIIIc could be considered as a lead compound that merits further optimization and development as an anti-cancer and an apoptotic inducing candidate against the HCT116 cell line.

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A novel strategy for efficient synthesis of various substituted heterocycles as kinase-directed combinatorial libraries is described. The general scheme involves capture of various dichloroheterocycles onto solid support and further elaborations by aromatic substitution with amines at elevated temperature or by anilines, boronic acids, and phenols via palladium-catalyzed cross-coupling reactions, thus the scaffold itself is transformed into a diversity element within the combinatorial scheme. Libraries consisting of discrete and highly diverse heterocyclic small molecules constructed with these chemistries are currently being evaluated in a variety of cell and protein-based assays. Copyright

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In the present study, twenty-five pyrazole-quinoxaline derivatives (4a-4y) were designed and synthesized, and their biological activity as potential EGFR or HER-2 kinase inhibitors was evaluated. Among them, compound 4l displayed better antiproliferative activity against A549 and MCF-7 cell lines than Eroltinib. Further kinase inhibitory activity assay results indicated that compound 4l demonstrated the most potent enzyme inhibitory activity. Docking simulations were then performed to position compounds 4l and 4x into the active binding site of EGFR to determine the probable binding model. 3D-QSAR models were built to aid in the effective design of the presently studied and future EGFR inhibitors. These discoveries suggested that the title compounds are potential EGFR/HER-2 dual inhibitors and compound 4l may be a promising lead compound for the development of novel antitumor agents, potentially via inhibiting EGFR/HER-2. This journal is

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This invention discloses four sulfur fois vinyl compound and its synthetic method, comprising the following steps : (1) synthesis of 4,5-b chlorophthalic anhydride ; (2) synthesis of 5,6-dichloro-2-cyclohexyl-isoindole -1,3-dione ; (3) synthesis of 5,6- two animal pen methylthio- -2-cyclohexyl-isoindole -1,3-dione ; (4) synthesis of 6-cyclohexyl -5H-[ 1,3] double-sulfur [4,5-f] isoindole -2, 5, 7 (6H)-trione ; (5) synthesis of 6,6 the-two cyclohexyl -5H […], the 5   H-[ 2,2 the […] -bis-[ 1,3] disulfide [4,5-f] different Asia indolyl] – 5,5 the […], 7,7 the […] (6H, 6H the […] ) four alkone. (by machine translation)

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2-Selenocyanatobenzophenone reacts with hydroxylamine to give 3-phenyl-1,2-benzisoselenazole N-oxide, the structure of which is indicated by polarographic reduction studies.The corresponding methyl and ethyl ketones react similarly but 3-methyl-2-selenocyanato acetophenone yields 4,8-dimethyl-2-imino-2H-1,3-benzoselenazine 3-oxide.Benzoselenopheno<3,2-b>indole is formed under mild conditions by action of phenylhydrazine on 2-selenocyanatoacetophenone. 12H-Quinoxalino<2,3-b><1,4>benzoselenazine is obtained by condensation of 2,3-dichloroquinoxaline with the Zn salt of 2-aminobenzeneselenol.

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In this investigation, quinoxaline derivatives namely, 2-(5-(2-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)naphtho[2,3-d]thiazole (CPTQ) and 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)naphtho[2,3-d]thiazole (DPTQ) were synthesized and applied as corrosion inhibitors for mild steel (MS) in15% HCl solution. The corrosion inhibition behaviour of CPTQ and DPTQ was studied through weight loss measurement, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). The maximum corrosion inhibition efficiency of DPTQ and CPTQ was found to be 96.01 and 95.62%, respectively at 100 ppm concentration and 303 K temperature. Potentiodynamic polarization studies showed that CPTQ and DPTQ act as mixed type inhibitors. Surface morphology of uninhibited and inhibited MS specimens was characterized using AFM and SEM studies. DFT, molecular dynamic simulations and calculation of Fukui functions were performed for correlation of theoretical parameters with the experimental results.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1530 | ChemSpider