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ARYLAMINE SUBSTUTUTED QUINOXALINE AND THEIR USE AS ANTICANCER DRUGS

The present invention provides new compounds of formula I and II, which have potential of protein phosphatase 2A (PP2A) agonistt, CIP2A inhibitor and SET antagonist. Also provided are treatment methods using the compounds of formula I and II.

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Facile assembly of fused benzofuro-heterocycles

This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

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Synthesis of new benzo-substituted macrocyclic ligands containing quinoxaline subunits

The macrocyclic Schiff bases 20-25 were prepared by cyclocondensation of the bis aldehydes 12-15 with the appropriate diaminoalkanes 17-19. Reduction of the latter with NaBH4 afforded the corresponding azacrown ethers 27-30. Heating of the aldehydes 12-16 in refluxing acetic acid afforded the corresponding 2,3-bis(benzofuranyl)quinoxalines 33-37. Nucleophilic reaction of the bis phenols 45-48, 54, 56, 57 with the appropriate dihalo compounds 1, 38 afforded the corresponding macrocyclic diamides 49-52 and 1,omega- bis[quinoxalino(2,3-b)benzoxazepino-13-on-yl]alkanes 60, 61, respectively. (C) 2000 Elsevier Science Ltd.

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Properties and Exciting Facts About 2,3-Dichloroquinoxaline

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AlCl3-mediated heteroarylation-cyclization strategy: One-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

An inexpensive, practical and one-pot method has been developed for the synthesis of quinoxalines fused with pyrano[3,4-b]indole, the central core of Lamellarin D. The methodology involved construction of the central pyranone ring via an AlCl3-mediated heteroarylation-cyclization method. A number of compounds were prepared using this methodology, some of which were converted to the corresponding indol-3-ylquinoxaline derivatives. Several of the pyrano[3,4-b]indole fused quinoxalines showed promising growth inhibition of cervical and lung cancer cells and good interactions with topoisomerase I in silico.

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Can You Really Do Chemisty Experiments About 2,3-Dichloroquinoxaline

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Electrochemical reduction of quinoxalino<2,3-b>quinoxaline

The electrochemical reduction of quinoxalino<2,3-b>quinoxaline gives fluoflavine (2) the structure of which is discussed.The electrochemical reduction of fluoflavine in acidic medium leads to a hexahydroquinolino<2,3-b>quinoxaline.A reduction mechanism is proposed based on cyclic voltammetry results and preparative electrolysis.The results obtained in the case of quinoxalino<2,3-b>quinoxaline are used to rationalize the results obtained in the case of pyrazino<2,3-b>pyrazines and pyrazino<2,3-b>quinoxalines.

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Discovery of 2,3-Dichloroquinoxaline

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Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

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Awesome Chemistry Experiments For 2,3-Dichloroquinoxaline

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QUINOXALINE DERIVATIVES

Compounds of the formula I in which R, R1 and R2 have the meanings indicated in Claim 1, are PI3K inhibitors and can be employed, inter alia, for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumours.

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ELECTROLUMINESCENT IMIDAZO-QUINOXALINE CARBENE METAL COMPLEXES

Metal carbene complexes comprising at least one imidazo-quinoxaline ligand, organic electronic devices, especially OLEDs (Organic Light- Emitting Diodes) which comprise such complexes, a light-emitting layer comprising at least one inventive metal carbene complex, an apparatus selected from the group consisting of illuminating elements, stationary visual display units and mobile visual display units comprising such an OLED, the use of such a metal carbene complex for electrophotographic photoreceptors, photoelectric converters, organic solar cells (organic photovoltaics), switching elements, organic light emitting field effect transistors (OLEFETs), image sensors, dye lasers and electroluminescent devices and a process for preparing such metal carbene complexes.

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AlCl3 induced C-arylation/cyclization in a single pot: A new route to benzofuran fused N-heterocycles of pharmacological interest

A new and one-pot synthesis of benzofuran fused N-heterocycles has been accomplished via AlCl3-mediated C-C followed by C-O bond formation between 2,3-dichloropyrazine or its derivatives and phenols. The methodology provided novel compounds as potential inhibitors of PDE4B. The single crystal X-ray data of a synthesized benzofuran derivative are presented. Scope of the methodology, in vitro pharmacological data of some of the synthesized compounds, along with docking study of an active compound are described.

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Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions

1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines are synthesized through the multi-component reaction of 3-substituted 2-chloroquinoxalines, propargyl bromide, and excess secondary amines in the presence of a palladium copper catalytic system. This one-pot process provides an unexpected synthesis of new trisubstituted pyrrolo[1,2-a]quinoxalines by the introduction of two amine substituents onto the fused pyrrole rings in a single reaction procedure. The compounds formed are fully characterized by the analytical spectral data and X-ray analysis. A number of synthesized pyrrolo[1,2-a]quinoxaline derivatives are also screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginos, and Bacillus subtilis. According to the results obtained, compounds 3b, 3c, and 3e are active against M.?luteus, compounds 3b and 3e are active against Ps. Aeruginos, and only compound 3f is active against all the three bacterial strains.

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