Category: 2213-63-0

2213-63-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article, authors is Soliman, Ahmed M.M.£¬once mentioned of 2213-63-0

Synthesis of some novel imidazopyrazole and pyrazolopyrimidine derivatives

Figure Persented 5-Amino-3-anilino-1H-pyrazole-4-carbonitrile 1 was alkylated with various halo reagents under phase transfer conditions to give the corresponding imidazopyrazole derivatives 2a-2c -6. Pyrazolo[1,5-a] pyrimidine derivatives 11, 12, 13, 14 were prepared by treating compound 1 with different dicarbonyl reagents, namely, diethymalonate, ethyl 3-oxo-3-phenylpropanoate, pentane-2,4-dione or ethyl 3-oxobutanoate.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.2213-63-0. In my other articles, you can also check out more blogs about 2213-63-0

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1550 | ChemSpider

2213-63-0, 2,3-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,3-dichloro-quinoxaline (500 mg, 2.51 mmol) in THF (5 mL) at 0 C. was added sodium methoxide (0.57 mL of a 25% solution in methanol, 2.51 mmol) dropwise. The reaction was stirred at 0 C. for 30 min then warmed to room temperature or 1 h. The reaction mixture was diluted with dichloromethane, washed with brine, dried (MgSO4), and concentrated in vacuo to give compound 76 as a yellow solid., 2213-63-0

As the paragraph descriping shows that 2213-63-0 is playing an increasingly important role.

Reference£º
Patent; Beavers, Mary Pat; Dudash, Joseph; Zhang, Yongzheng; US2005/148586; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 21Preparation of Compound 59Step A – Synthesis of lnt-21AInt-19A (4.0 g, 20 mmol) was combined with NH4CI (5.4 g, 100 mmol) and 27% ammonia (32 mL) in isopropanol (40 mL). The mixture was heated in a sealed vessel for 20 h at 80 C, allowed to cool, and partitioned with CH2Cl2 and water. Washing with brine, drying (MgSO4), and concentration gave Int-21 A as a yellow solid., 2213-63-0

As the paragraph descriping shows that 2213-63-0 is playing an increasingly important role.

Reference£º
Patent; SCHERING CORPORATION; HARRIS, Joel, M.; NEUSTADT, Bernard, R.; STAMFORD, Andrew, W.; WO2011/60207; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

2-Amino-3-chloroquinoxaline (2a). The compound was synthesized by a slightly modified version of the procedure of Saikachi and Tagami [1] using a reaction temperature of only 80 C. Compound 1 (8.0 g, 40.2 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (60 mL) and heated to 80 ?C. Then, ammonia gas was bubbled through the hot solution for 3 h while the reaction was monitored by TLC. The crude product was poured into water (100 mL). The precipitate was collected by filtration, dried over CaCl2 and crystallized from chloroform to give 4.8 g (63%) pale yellow crystals, mp. 137-139 C. The NMR data are in accordance with a semihydrate. 1H-NMR (CDCl3): delta 1.85 (br, 1 H, 0.5 H2O), 5.53 (br s, 2 H, NH2), 7.47 (td, 3J = 8.3, 6.8, 4J = 1.7 Hz, 1 H, H-6), 7.63 (td, 3J = 8.3, 6.8, 4J = 1.4 Hz, 1 H, H-7), 7.69 (ddd, 3J = 8.3, 4J = 1.5, 5J = 0.5 Hz, 1 H, H-8), 7.86 ppm (ddd, 3J = 8.2, 4J = 1.3, 5J = 0.5 Hz, 1 H, H-5). 13C-NMR (CDCl3): delta 125.4 (CH-6), 126.1 (CH-8), 128.1 (CH-5), 130.6 (CH-7), 137.1, 137.3 (Cq-4a, Cq-3), 140.3 (Cq-8a), 148.7 ppm (Cq-2). MS (EI 70 eV, 165 ?C): m/z (%) = 181 (30) [M+(37Cl)], 179 (100) [M+(35Cl)], 144 (84), 117 (23), 102 (8), 90 (26), 44 (81). Water was separated by azeotropic distillation with toluene at normal pressure. Residual toluene was removed in vacuum. Anal. Calcd for C8H6ClN3 (179.61 gmol-1): C, 53.50; H, 3.37; N 23.40. Found: C, 53.59; H, 3.40; N 22.96.

2213-63-0, The synthetic route of 2213-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adam, Mohamed Shaker S.; Mohamad, Ahmad Desoky; Jones, Peter G.; Kindermann, Markus K.; Heinicke, Joachim W.; Polyhedron; vol. 50; 1; (2013); p. 101 – 111;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

2213-63-0, 2,3-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of sodium (1 mmol) and an alcohol (3 mL) was stirred for 15 min at room temperature. Then 2,3-dichloroquinoxaline (1 mmol) was added to the mixture until the complete consumption of the starting materials (monitored by TLC). After evaporation of the solvent, the resulting precipitate was washed with H2O; it did not require any further purification., 2213-63-0

The synthetic route of 2213-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Keivanloo, Ali; Soozani, Atena; Bakherad, Mohammad; Mirzaee, Mahdi; Rudbari, Hadi Amiri; Bruno, Giuseppe; Tetrahedron; vol. 73; 12; (2017); p. 1633 – 1639;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of sodium (1 mmol, 0.023 g) and alcohol (3 mL) was stirred for 15 min at room temperature. Then 2,3-dichloroquinoxaline (1 mmol, 0.199 g) was added to the mixture until the complete consumption of the starting materials, monitored by TLC. After evaporation of the solvent, the resulting precipitate was washed with H2O; it did not require any further purification., 2213-63-0

As the paragraph descriping shows that 2213-63-0 is playing an increasingly important role.

Reference£º
Article; Keivanloo, Ali; Kazemi, Shaghayegh Sadat; Nasr-Isfahani, Hossein; Bamoniri, Abdolhamid; Tetrahedron; vol. 72; 41; (2016); p. 6536 – 6542;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

Reference Example 20 To a suspension of 2,3-dichloroquinoxaline (300 mg, 1.51 mmol) in methanol (15 mL) and N,N-dimethylformamide (1.0 mL) was added sodium methoxide (28% in methanol, 309 mg, 1.66 mmol) dropwise at 0 0C. After being stirred for 2 hour at room temperature, the reaction mixture was concentrated in vacuo. The residue was diluted with chloroform and water. The organic layer was separated with phase separator and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane to hexane: ethyl acetate = 19: 1) to give 2-chloro-3-methoxyquinoxaline (the compound of Reference Example 20 listed in Table of Reference Example as described hereinafter) as a colorless powder (251 mg,%)., 2213-63-0

The synthetic route of 2213-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; MORIMOTO, Hiroshi; SAKAMOTO, Toshiaki; HIMIYAMA, Toshiyuki; KAWANISHI, Eiji; MATSUMURA, Takehiko; WO2010/30027; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider