Category: 23088-23-5

Reference of 23088-23-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 23088-23-5, Name is Methyl 6-Quinoxalinecarboxylate,introducing its new discovery.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1094 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of Methyl 6-Quinoxalinecarboxylate. Introducing a new discovery about 23088-23-5, Name is Methyl 6-Quinoxalinecarboxylate

1. 2, 3, 4 – Tetrahydroquinoxaline -6 – carboxylic acid methyl ester and its preparation method (by machine translation)

The invention discloses a 1, 2, 3, 4 – tetrahydroquinoxaline – 6 – carboxylic acid methyl ester and its preparation method, the 1, 2, 3, 4 – tetrahydroquinoxaline – 6 – carboxylic acid methyl ester is of the structural formula . Preparation method is as follows: first of all the low priced starting material 3, 4 – diaminobenzoic acid suspended in anhydrous methanol, by use of the concentrated sulfuric acid catalyzed esterification of 3, 4 – diaminobenzoic acid methyl ester; then the 3, 4 – diaminobenzoic acid methyl ester with [1, 4] dioxan – 2, 3 – diol condensation ring make the quinoxaline – 6 – carboxylic acid methyl ester; last-used common reducing agent sodium borohydride will quinoxaline – 6 – carboxylic acid methyl ester reduction to obtain 1, 2, 3, 4 – tetrahydroquinoxaline – 6 – carboxylic acid methyl ester. The preparation line and used by the method of the reagent, mild reaction conditions, the middle step and the product is easy to purification processing, provides a process for preparing 1, 2, 3, 4 – tetrahydroquinoxaline – 6 – carboxylic acid methyl ester of the new method. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of Methyl 6-Quinoxalinecarboxylate, you can also check out more blogs about23088-23-5

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1095 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. name: Methyl 6-Quinoxalinecarboxylate, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 23088-23-5

SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1093 | ChemSpider

Reference of 23088-23-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.23088-23-5, Name is Methyl 6-Quinoxalinecarboxylate, molecular formula is C10H8N2O2. In a article£¬once mentioned of 23088-23-5

NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND

The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula -NH-C(=O)-, a group represented by the formula -C(=O)-NH-, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 23088-23-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1090 | ChemSpider

Synthetic Route of 23088-23-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 23088-23-5, molcular formula is C10H8N2O2, introducing its new discovery.

Esters of quinoxaline 1?4-Di-N-oxide with cytotoxic activity on tumor cell lines based on NCI-60 panel

Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1?4-di-N-oxide derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1?4-di-N-oxide substitutes at 7-position with esters group were synthetized and characterized by infrared (IR), proton nuclear magnetic resonance (1H-NMR), spectroscopy, and elemental analysis. Seventeen derivatives (M1-M3, E1-E8, P1-P3 and DR1-DR3) were selected and evaluated for antitumor activities using the NCI-60 human tumor cell lines screen. Results showed that E7, P3 and E6 were the most active compounds against the cell lines tested. Substitutions at 7-position with esters group not necessarily affect the biological activity, but the nature of the esters group could exert an influence on the selectivity. Additionally, substitutions at 2-position influenced the cytotoxic activity of the compounds.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 23088-23-5 is helpful to your research. Synthetic Route of 23088-23-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1097 | ChemSpider

Related Products of 23088-23-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 23088-23-5, Methyl 6-Quinoxalinecarboxylate, introducing its new discovery.

1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS

The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 23088-23-5. In my other articles, you can also check out more blogs about 23088-23-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1092 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C10H8N2O2. Introducing a new discovery about 23088-23-5, Name is Methyl 6-Quinoxalinecarboxylate

AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES

The invention concerns amide derivatives of formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q 1 is heteroaryl which is optionally substituted with 1, 2, 3, or 4 substituents such as hydroxy, halogeno, trifluoromethyl, (1-6C)alkyl, (1-6C)alkoxy, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, amino-(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, heteroaryl and heterocyclyl; p is 0-2 and R 2 is a substituent such as hydroxy and halogeno; q is 0-4; and Q 2 includes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C10H8N2O2, you can also check out more blogs about23088-23-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1089 | ChemSpider

23088-23-5, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 23088-23-5, name is Methyl 6-Quinoxalinecarboxylate. In an article£¬Which mentioned a new discovery about 23088-23-5

Structural requirements for potential Na/H exchange inhibitors obtained from quantitative structure-activity relationships of monocyclic and bicyclic aroylguanidines.

The quantitative structure-activity relationship (QSAR) of N-(3-amino-6-chloro-5-ethylisopropylaminopyrazine-4-carbonyl) guanidine (EIPA) 1ac and its derivatives as Na/H exchange inhibitors was analyzed using th steric parameters and an indicator variable. The results indicated that bicyclic aroylguanidines might have Na/H exchange inhibitory activity. Therefore, various bicyclic aroylguanidines were synthesized and tested for Na/H exchange inhibitory activity. The QSAR study of the bicyclic aroylguanidines showed that hydrophobic bicyclic rings seemed to be preferable for potent activity. The hydrophobicity of the aroyl ring moiety was thought to be particularly important. Thus, the QSAR of EIPA and its derivatives was re-analyzed using hydrophobicity and steric parameters. The results indicated that high hydrophobicity of the pseudo-ring moiety and a substituent of appropriate length at the position corresponding to the 5-position of the naphthalene ring enhance the activity. As expected from the results, 5-bromo-2-naphthoylguanidine 3b and 5-methoxy-2-naphthoylguanidine 3c exhibited strong activity. These findings will be helpful to design new, potent Na/H exchange inhibitors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 23088-23-5 is helpful to your research. 23088-23-5

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1098 | ChemSpider

23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 2-(2-Chloro-4-methoxy-phenyl)-1-quinoxalin-6-yl-ethanone A 2M solution of tert-butylmagnesium chloride (CAS Reg. No. 677-22-5) in diethyl ether (5.9 ml) was added to 2-chloro-4-methoxyphenylacetic acid (1.173 g, CAS Reg. No. 91367-09-8) in THF (10 ml). The mixture was stirred at room temperature for 30 min. A solution of methyl 6-quinoxalinecarboxylate (1 g, CAS Reg. No. 23088-23-5) in THF (3 ml) was added and the resulting mixture was stirred overnight. Aqueous HCl (25%, 1.5 ml) and water (30 ml) were added and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and then concentrated to an oil. The residue was purified by flash chromatography (SiO2, EtOAc/heptane 1:2) to give the title compound (480 mg) as a light brown solid. MS (m/e)=313.2 [M+H+].

23088-23-5, The synthetic route of 23088-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249139; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation Example I-1. Quinoxaline-6-carboxylic acid To a solution of quinoxaline-6-carboxylic acid methyl ester (2084mg, 11.07mmol) in ethanol (25mL) was added an aqueous solution of 1 N sodium hydroxide (25mL), and the solution was stirred for 4 hours under reflux. 1 N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, then, the precipitated solid was collected by filtration, washed with water and isopropanol, then dried to obtain the title compound (1477mg, 8.479mmol, 76.6%) as a solid. 1H-NMR Spectrum (DMSO-d6) delta (ppm): 8.18 (1 H, d, J=8.4Hz), 8.29 (1H, dd, J=8.4, 1.2Hz), 8.61 (1 H, d, J=1.2Hz), 9.00-9.07 (2H, m)., 23088-23-5

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Reference£º
Patent; Eisai R&D Management Co., Ltd.; EP1782811; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider