Category: 2379-56-8

2379-56-8, In an article, published in an article,authors is Cai, Sui Xiong, once mentioned the application of 2379-56-8, Name is 6-Nitroquinoxaline-2,3-dione,molecular formula is C8H3N3O4, is a conventional compound. this article was the specific content is as follows.

5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: Novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors

A group of 5-aza-7-substituted-1,4-dihydroquinoxaline-2,3-diones (QXs) and the corresponding 5-(N. oxyaza)-7-substituted QXs were prepared and evaluated as antagonists of ionotropic glutamate receptors. The in vitro potency of these QXs was determined by inhibition of [3H]-5,7- dichlorokynurenic acid ([3H]DCKA) binding to N-methyl-D-aspartate (NMDA)/glycine receptors, [3H]-(S)-alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid ([3H]AMPA) binding to AMPA receptors, and [3H]kainate ([3H]KA) binding to KA receptors in rat brain membranes. 5-(N- Oxyaza)-QXs 12a-e all have low micromolar or submicromolar potency for NMDA/glycine receptors and low micromolar potencies for AMPA and KA receptors. QXs 12a-e display 2-12-fold selectivity for NMDA/glycine receptors compared to AMPA receptors, and ~2-fold difference between AMPA and KA potency. In contrast to other QXs that either show high selectivity for NMDA (such as ACEA 1021) or AMPA (such as NBQX) receptors, these molecules are broad spectrum antagonists of ionotropic glutamate receptors. 7-Nitro-5-(N- axyaza)-QX (12e) is the most potent inhibitor among 12a-e, having IC50 values of 0.69, 1.3, and 2.4 muM at NMDA, AMPA, and KA receptors, respectively. In functional assays on glutamate receptors expressed in oocytes by rat cerebral cortex poly(A+) RNA, 7-chloro-5-(N-oxyaza)-QX (12a) and 7-nitro-5(N-oxyaza)-QX (12e) have K(b) values of 0.63 and 0.31 muM for NMDA/glycine receptors, and are 6- and 4-fold selective for NMDA over AMPA receptors, respectively. 5-(N-Oxyaza)-7-substituted-QXs 12a-e all have surprisingly high in vivo potency as anticonvulsants in a mouse maximal electroshock-induced seizure (MES) model. 7-Chloro-5-(N-oxyaza)-QX (12a), 7- bromo-5-(N-oxyaza)-QX (12b), and 7-methyl-5-(N-oxyaza)-QX (12c) have ED50 values of 0.82, 0.87, and 0.97 mg/kg iv, respectively. The high in vivo potency of QXs 12a-e is particularly surprising given their low log P values (~ -2.7). Separate studies indicate that QXs 12a and 12e are also active in vive as neuroprotectants and also have antinociceptive activity in animal pain models. In terms of in vivo activity, these 5-(N-oxyaza)-7-substituted- QXs are among the most potent broad spectrum ionotropic glutamate antagonists reported.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1696 | ChemSpider

2379-56-8, An article , which mentions 2379-56-8, molecular formula is C8H3N3O4. The compound – 6-Nitroquinoxaline-2,3-dione played an important role in people’s production and life.

Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening

N-Ureido-quinoxalinedione derivatives have been discovered as leads for a novel series of dipeptidyl peptidase-IV (DPP-IV) inhibitors through high-throughput screening of our chemical library. A brief structure-activity relationship of the compounds was investigated. Among them, entry 5 showed the most potent inhibitory activity. The nitro group in quinoxaline moiety and the aromatic sulfonyl substituted ureido functional group seem to be important to increase the potency dramatically.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1698 | ChemSpider

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2379-56-8, Name is 6-Nitroquinoxaline-2,3-dione, molecular formula is C8H3N3O4, 2379-56-8, In a Article, authors is Obefami, Craig A.£¬once mentioned of 2379-56-8

Synthesis and Some Reactions of 3-Chloro-2-(cyanomethylene)-1,2-dihydroquinoxalines

2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and ethyl cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene)-1,2-dihydroquinoxaline derivatives. The reaction of 3-chloro-2-(dicyanomethylene)-1,2-dihydroquinoxaline (2e) with pyridine and its methyl derivatives led to the zwitterionic structures 6a-c. The structures of the newly synthesized compounds were assigned by spectroscopic data and elemental analyses.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.2379-56-8. In my other articles, you can also check out more blogs about 2379-56-8

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1710 | ChemSpider

2379-56-8, 6-Nitroquinoxaline-2,3-dione is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Nitroquinoxaline-2,3-(1H,4H)-dione (12 g, 59.0 mmol), thionylchloride (28.1 g, 236 mmol) and catalytic amount of dimethylformamide (0.86 g, 11.8 mmol) were dissolved in dichloroethane solvent, followed by reflux stirring for 2 hours. Upon completion of the reaction, the solvent was eliminated. The temperature was lowered to 05C. to solidify the product. The resulting solid was filtered, and dried under reduced pressure. As a result, 12.3 g of a target compound was obtained (87% yield). Mass (M+H +): 244.1 1H NMR (300 MHz, DMSO-d6): delta8.31 (d, J=9.15 Hz, 1H), 8.60 (d, J=9.15 Hz, 1H), 8.88 (s, 1H)., 2379-56-8

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Patent; Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology; Lee, Kwangho; Choi, Gildon; Ali, Imran; Lee, Joo Yun; Lee, Jin Soo; Park, Whui Jung; Kim, Yong Tae; Kim, Seung Hwan; Kim, Jung Hwan; Lim, Jae-Kyung; (250 pag.)US2020/39984; (2020); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider