Category: 2427-71-6

New learning discoveries about 2427-71-6

2427-71-6 6-Chloro-2(1H)-quinoxalinone 75507, aquinoxaline compound, is more and more widely used in various fields.

2427-71-6, 6-Chloro-2(1H)-quinoxalinone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloroquinoxalin-2(1H)-one (1.0 g, 5.5 mmol) and phosphorus tribromide (PBr3; 3.5 mL, 36.1 mmol) was heated at 120 C. for 4 h. The reaction mass was cooled to RT, diluted with cold H2O and extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, filtered and concentrated under vacuum to get crude product. The crude compound was purified by silica gel column chromatography (eluting with EtOAc/hexane) to afford 2-bromo-6-chloroquinoxaline (550 mg, 2.26 mmol, 42%) as a solid. 1H NMR (200 MHz, CDCl3): delta 8.86 (s, 1H), 8.11 (s, 1H), 7.99 (d, J=8.8 Hz, 1H), 7.75 (dd, J=9.0, 2.4 Hz, H). MS (ESI): m/z 243 [M+]., 2427-71-6

2427-71-6 6-Chloro-2(1H)-quinoxalinone 75507, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; US2012/329802; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

Analyzing the synthesis route of 2427-71-6

2427-71-6, As the paragraph descriping shows that 2427-71-6 is playing an increasingly important role.

2427-71-6, 6-Chloro-2(1H)-quinoxalinone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 6 1-Carboxymethyl-6-chloroquinoxaline-2,3(1H,4H)-dione In accordance with the procedure described in example 1 the title compound was prepared starting from 6-chloroquinoxalin-2(1H)-one (Heterocycles, 23 , (1985), 143). M.p. 318-19C. 1-NMB (DMSO-d6: delta 4.88 (s, 2H), 7.30-7.40 (m, 3H), 12.25 (s, 1H), 13.32 (br.s, 1H). Analysis: Calculated for C1072lO4 C, 47.17; H, 2.77; N, 11.00; Cl, 13.92%. Found: C, 47.12; H, 2.79; N, 10.96; Cl, 13.89%.

2427-71-6, As the paragraph descriping shows that 2427-71-6 is playing an increasingly important role.

Reference£º
Patent; NOVO NORDISK A/S; EP520024; (1996); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

Simple exploration of 2427-71-6

The synthetic route of 2427-71-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2427-71-6,6-Chloro-2(1H)-quinoxalinone,as a common compound, the synthetic route is as follows.

EXAMPLE 6 1-Carboxymethyl-6-chloroquinoxaline-2,3(1H,4H)-dione In accordance with the procedure described in example 1 the title compound was prepared starting from 6-chloroquinoxalin-2(1H)-one (Heterocycles, 23, (1985), 143). M.p. 318-19 C. 1 H-NMR (DMSO-d6):delta4.88 (s, 2H), 7.30-7.40 (m, 3H), 12.25 (s, 1H), 13.32 (br.s, 1H). Analysis: Calculated for C10 H7 N2 ClO4: C, 47.17; H, 2.77; N, 11.00; Cl, 13.92%. Found: C, 47.12; H, 2.79; N, 10.96; Cl, 13.89%., 2427-71-6

The synthetic route of 2427-71-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novo Nordisk A/S; US5166155; (1992); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

Brief introduction of 2427-71-6

As the paragraph descriping shows that 2427-71-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2427-71-6,6-Chloro-2(1H)-quinoxalinone,as a common compound, the synthetic route is as follows.

EXAMPLE 4 6-Chloro-1,2,3,4-tetrahydroquinoxalin-2-one (IV) Sodium borohydride (5.10 g) is added to a mixture of 6-chloro-1,2-dihydroquinoxalin-2-one (5.60 g), and ethanol (200 ml). The resultant solution is stirred for 2.5 hr at 20-25. The material is partitioned between water and ethyl acetate, the phases are separated, the organic phase is dried over magnesium sulfate and concentrated under reduced pressure to give a solid which is recrystallized from ethyl acetate/hexane to give the title compound, mp 171-174; IR (mineral oil) 2953, 2925, 1687, 1517, 1408, 1307 and 1299 cm-1; NMR (CDCl3 -MeOD) 6.6-6.8 and 3.95 delta; MS (m/z) 182, 153.

As the paragraph descriping shows that 2427-71-6 is playing an increasingly important role.

Reference£º
Patent; The Upjohn Company; US5541324; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider