Category: 25594-62-1

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 2-Acetylquinoxaline, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 25594-62-1, name is 2-Acetylquinoxaline. In an article£¬Which mentioned a new discovery about 25594-62-1

Enantioselective Conjugate Addition of 2-Acetyl Azaarenes to beta,beta-Disubstituted Nitroalkene for the Construction of All-Carbon Quaternary Stereocenters

The first highly enantioselective conjugate addition of 2-acetyl azaarenes to alpha-substituted-beta-nitroacrylates was successfully realized under mild conditions by a Ni(II)-bisoxazoline complex, providing the desired adducts bearing an all-carbon quaternary stereocenter in high yield with excellent enantioselectivity. The products obtained in this system could be readily converted into optically active beta2,2-amino esters, succinates, lactones, and lactams.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N756 | ChemSpider

25594-62-1, Name is 2-Acetylquinoxaline, belongs to quinoxaline compound, is a common compound. Application In Synthesis of 2-AcetylquinoxalineIn an article, once mentioned the new application about 25594-62-1.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents, wherein: R1, R2 and R3 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N743 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 25594-62-1, name is 2-Acetylquinoxaline, introducing its new discovery. Quality Control of 2-Acetylquinoxaline

An efficient approach for the construction of trifluoromethylated all-carbon quaternary stereocenters: Enantioselective Ni(ii)-catalyzed Michael addition of 2-acetyl azaarene to beta,beta-disubstituted nitroalkenes

The first example of a highly enantioselective Michael addition of 2-acetyl azaarenes with beta,beta-disubstituted nitroalkenes was achieved using a Ni(acac)2-bisoxazoline complex as a catalyst, which afforded chiral compounds with an all-carbon quaternary stereocenter bearing a CF3 group in good yields with excellent enantioselectivities (up to >99% ee). This reaction, featuring mild conditions, excellent enantioselectivity and broad generality, provides a new efficient strategy for the construction of trifluoromethylated all-carbon quaternary stereocenters.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N753 | ChemSpider

Electric Literature of 25594-62-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 25594-62-1, Name is 2-Acetylquinoxaline, molecular formula is C10H8N2O. In a Article£¬once mentioned of 25594-62-1

AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C-H bond and direct conversion of 2-methyl quinoxalines into related nitriles

A unique method for AgNO2-mediated direct nitration of the quinoxaline tertiary C-H bond and direct conversion of 2-methyl quinoxalines into 2-quinoxaline nitriles under oxidative conditions has been developed. This protocol provides an efficient way to access quinoxaline containing nitroalkanes and nitriles depending on different substrate selection. the Partner Organisations 2014.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 25594-62-1. In my other articles, you can also check out more blogs about 25594-62-1

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N763 | ChemSpider

Because a catalyst decreases the height of the energy barrier, 25594-62-1, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.25594-62-1, Name is 2-Acetylquinoxaline, molecular formula is C10H8N2O. In a article£¬once mentioned of 25594-62-1

Asymmetric Michael Addition of 2-Acetyl Azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex

The first enantioselective Michael addition of 2-acetyl azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst. The reaction affords a series of CF3- A nd 3-indole-containing adducts featuring a trifluoromethylated all-carbon quaternary stereocenter in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee). Furthermore, the functional groups in the adducts including Ca?O, NO2, and the azaarene provide a large variety of useful transformations, leading to the formation of valuable intermediates such as optically active secondary alcohol, pyrroline, ester, and pyrrolidinone which all contain a 3-substituted indole and a trifluoromethylated all-carbon quaternary stereocenter.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 25594-62-1, In my other articles, you can also check out more blogs about 25594-62-1

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N761 | ChemSpider

Chemistry can be defined as the study of matter and the changes it undergoes. 25594-62-1. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.25594-62-1, Name is 2-Acetylquinoxaline, molecular formula is C10H8N2O, introducing its new discovery.

Chloroacetate-promoted selective oxidation of heterobenzylic methylenes under copper catalysis

The efficient selective oxidation and functionalization of C-H bonds with molecular oxygen and a copper catalyst to prepare the corresponding ketones was achieved with ethyl chloroacetate as a promoter. In this transformation, various substituted N-heterocyclic compounds were well tolerated. Preliminary mechanistic investigations indicated that organic radical species were involved in the overall process. The N-heterocyclic compounds and ethyl chloroacetate work synergistically to activate C-H bonds in the methylene group, which results in the easy generation of free radical intermediates, thus leading to the corresponding ketones in good yields.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N755 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25594-62-1,2-Acetylquinoxaline,as a common compound, the synthetic route is as follows.

Scheme A14 l-(quinoxalin-2-yl)ethanone (1.13 g, 6.56 mmol) and N,N-dimethylacetamide dimethylacetal (1.173 ml, 7.22 mmol) were combined and heated to 100 C for 3h. The mixture was cooled to r.t. 1H NMR indicated that the material was sufficiently pure to carry onto the next step without further purification (1.49g, 94% yield). 3-(dimethylamino)-l-(quinoxalin-2-yl)but- 2-en-l-one (791 mg, 3.28 mmol) and methylhydrazine (0.174 ml, 3.28 mmol) were combined in acetic acid (6 ml) and stirred at 55 C until the reaction was judged to be complete by LCMS. The acetic acid was removed and the material was taken up in DCM and washed with saturated NaHC03 solution. The organic extracts were dried over Na2S04, filtered, and concentrated. 1H NMR (500 MHz, CDC13) delta 9.14 (1H, s), 8.13-8.1 1 (2H, m), 7.83-7.77 (2H, m), 6.72 (1H, s), 4.37 (3H, s), 2.39 (3H, s). MS m/z = 225.3.

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Reference£º
Patent; MERCK SHARP & DOHME CORP.; ANAND, Rajan; COLANDREA, Vincent, J.; REITER, Maud; VACHAL, Petr; ZWICKER, Aaron; WILSON, Jonathan, E.; ZHANG, Fengqi; ZHAO, Kake; WO2013/28382; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

25594-62-1, 2-Acetylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 22-bromo-1 -(quinoxalin-2-yl)ethanone (JS111 )Pyridinium tribromide (2.935 g, 9.18 mmol) was added to a stirred solution of JS1 10 (580 mg, 3.67 mmol) in 1 :1 CHCI3/EtOH (60 ml) and the mixture was heated at 50 C for 16 h. Removal of the solvent in vacuo was followed by addition of H20 and extraction with EtOAc (3x). The combined organic extracts were further washed with H20 and brine, dried (MgS04), filtered and concentrated in vacuo. Flash chromatography (CH2CI2 isocractic) afforded the title compound as a brown solid (656 mg, 2.61 mmol, 71 .2%). Mpt: Decomposed before melting [Lit. (Pharmazie 1983, 38(12), 829-32) 1 12-1 14 C]; Rf = 0.26 (CH2CI2); IR (vmax/crrf1, thin film): 1708 (CO stretch), 1392, 762 (C-Br Stretch); 1 H NMR (600 MHz, CDCI3): deltaEta = 4.96 (s, 2H, 12-H), 7.88-7.90 (m, 1 H, 8-H), 7.93-7.96 (m, 1 H, 7-H), 8.20-8.21 (m, 2H, 6,9-H), 9.53 (s, 1 H, 3-H); 13C NMR (150 MHz, CDCI3): 5C = 31.3 (C-12), 129.7 (C-6), 130.6 (C-9), 131 .3 (C- 8), 133.0 (C-7), 141.0 (C-10), 143.4 (C-3), 144.3 (C-5), 144.7 (C-2), 192.4 (C-11 ); LRMS m/z (El+): 252 [M(81Br)]+, 250 [M(79Br)]+, 142, 1 15 [(81Br)], 1 13 [(79Br)]; HRMS m/z (Epsilon ): Found 249.97396; Ci0H7BrN2O requires 249.97363; Anal. Calcd. for Ci0H7BrN2O: C, 47.84; H, 2.81 ; N, 1 1 .16. Found C, 47.70; H, 2.68; N, 10.86%., 25594-62-1

25594-62-1 2-Acetylquinoxaline 11105814, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin; WO2012/168733; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider