Category: 2958-87-4

2958-87-4, 2,3,6-Trichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 20 By reaction of 2,3,6-trichloroquinoxaline with propargylamine, following a procedure that is similar to that described in example 2, there is obtained 8-chloro-1-methylimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.) and, subsequently, 4,8-dichloro-1-methylimidazo[1,2-a] quinoxaline., 2958-87-4

2958-87-4 2,3,6-Trichloroquinoxaline 18070, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

A suspension of 2,3,6-trichloroquinoxaline (J. Med. Chem. 33, 2240-54,1990) (5.84 g, 25 mmol) in dry methanol (70 ml) was stirred at 50 C. while methanolic sodium methoxide (30 mmol) (prepared from 0.7 g of sodium and 70 ml of dry methanol) was added over 5 hours. After the addition was complete, heating and stirring was continued for a further 16 hours. The mixture was cooled in an ice bath, the precipitate filtered off, washed with a small amount of methanol and dried to afford 4.28 g of a mixture consisting of 2,3-dimethoxy-6-chloroquinoxaline, 2,6-dichloro-3-methoxyquinoxaline and 3,6-dichloro-2-methoxy-quinoxaline, respectively., 2958-87-4

The synthetic route of 2958-87-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novo Nordisk A/S; US6927214; (2005); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 17 By reaction of 2,3,6-trichloroquinoxaline with aminoacetaldehyde dimethyl acetal, according to a procedure that is similar to that followed in example 1, there is obtained 8-chloroimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.)., 2958-87-4

As the paragraph descriping shows that 2958-87-4 is playing an increasingly important role.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 2 9-Chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline and 10-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline A mixture of 23.3 g. of 2,3,6-trichloroquinoxaline, 11.5 g. of 2-piperidinomethanol, 40 ml. of triethylamine and 400 ml. of dimethylformamide is stirred at room temperature for 4 hours and then heated on a steam bath for 48 hours. A 500 ml. portion of water is added dropwise. The solid is recovered by filtration, washed with water and air dried. This solid is dissolved in dichloromethane, passed through Magnesol and recrystallized from ethyl acetate. Recrystallization from ethanol or ethyl acetate gives pale yellow crystals of 10-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 147-149 C. Fractional crystallization from the mother liquor gives a second yield of the above 10-chloro derivative plus 9-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 107-109 C. The monohydrochloride salts of both compounds may be prepared as described in Example 1 and decompose above 300 C., 2958-87-4

2958-87-4 2,3,6-Trichloroquinoxaline 18070, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; American Cyanamid Company; US4200748; (1980); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider