Category: 34413-35-9

On June 5, 2018, Jumal, Juliana; Ayomide, Adetunji Fridaos published an article.Related Products of 34413-35-9 The title of the article was Synthesis and radical scavenging activity of 6-hydroxyl-4-methylcoumarin and its derivatives. And the article contained the following:

Four compounds of coumarin derivatives namely 6-hydroxyl-4-methylcoumarin (I), 6-hydroxyl-4-methyl-5-(p-nitrophenyl azocoumarin) (II), 6-hydroxyl-4-methyl-5,7-(bis-p-nitrophenyl azocoumarin) (III) and 6-hydroxyl-4-methyl-5,7-(bis-p-chlorophenyl azocoumarin) (IV) were successfully synthesized. These compounds were prepared by reacting hydroquinone with ethylacetoacetate and selected anilines which are chloro and nitro aniline. All synthesized compounds were characterized by CHN micro-elemental anal., 1H NMR (NMR) and Fourier Transform IR (FTIR) spectroscopic methods. The IR spectra of these compounds exhibited five important stretching vibrations: (-OH), (C=O), (C=C), (C-O) and (C-N) at 3441-3359 cm-1, 1604-1632 cm-1, 1581-1496 cm-1, 1331-1225 cm-1, 1251-1109 cm-1, resp. 1H NMR spectra of these compounds show the presence of proton aromatic, proton Me and proton pyrone ring with the chem. shift at δH 7.00-8.70 ppm, δH 2.20-2.50 ppm and δH 6.10-6.90 ppm, resp. CHN anal. results of all compounds are in good agreement with the calculated values. All the synthesized compounds were evaluated for their antioxidant activity using DPPH method and ascorbic acid used as the standard UV-Vis spectroscopic technique was used to investigate the absorbance of these compounds Compound (II) shows high antioxidant activities compared to compound (I), (III) and (IV) which show moderate to low activities. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Related Products of 34413-35-9

5,6,7,8-Tetrahydroquinoxaline(cas:34413-35-9) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Related Products of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gu, Junping; Tao, Hong; Wang, Junxia; Chen, Senlin; Ouyang, Lusi; Lin, Baomin; Lu, Jiajian published an article in 2021, the title of the article was Effects of cigarette filter design on release behavior of monomer flavor in breakable capsule.Category: quinoxaline And the article contains the following content:

In order to investigate the influences of cigarette filter design on the release of monomer flavor components in breakable capsules, the effects of capsule location in filter and filter ventilation on the transfer rates and puff-by-puff releases of 40 representative monomer flavor components in mainstream cigarette smoke were analyzed. The results showed that: 1) Capsule location in filter and filter ventilation levels significantly affected the transfer rates of the aroma components. The transfer rates of the monomer aroma components were higher when the capsule was planted at 6 mm to the mouth end as compared to those at 18 mm, or when the filter was unventilated. With the increase of the mol. weight of flavor compound, the transfer rate ratios between the capsule planted at 6 mm and that at 18 mm of the same component in alc., ketone and ester homologues presented different variation trends. The transfer rate ratios when the filter was unventilated to that of ventilated of the same component in these homologues deceased. 2) The puff-by-puff releases and the puff-by-puff releases per unit TPM of monomer aroma components were higher when the capsule was planted at 6 mm than at 18 mm. The puff-by-puff releases were higher and the puff-by-puff releases per unit TPM were lower when the filter was unventilated than ventilated. 3) The releases of those aroma components with a lower b.p., such as Et hexanoate, Et heptanoate, 2-heptanone, 2-octanone and 1-pentanol, increased significantly at the fourth and fifth puffs. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Category: quinoxaline

The Article related to cigarette filter alc ketone ester, cigarettes and other aspects.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Walradt, John P.; Pittet, Alan O.; Kinlin, Thomas E.; Muralidhara, Ranya; Sanderson, Anne published an article in 1971, the title of the article was Volatile components of roasted peanuts.Application of 34413-35-9 And the article contains the following content:

Steam volatile components from roasted Spanish peanuts were fractionated by preparative gas chromatog. Individual fractions were analyzed on a Carbowax 20M gas chromatog. column coupled to a mass spectrometer. Compounds reported for the first time from roasted peanuts include phenols, pyrazines, thiazoles, pyridines, aromatic hydrocarbons, and terpenes. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Application of 34413-35-9

The Article related to peanut volatile component, chromatog volatiles peanut, arachis hypogaea, peanut, phenols, terpenes role: anst (analytical study), volatile substances and other aspects.Application of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Li, Qian; Duan, Zheng-kang; Luo, He-an; Yao, Yuan-yuan published an article in 2016, the title of the article was Analysis of solvent extracts from coal with gas chromatography-mass spectrometry.Related Products of 34413-35-9 And the article contains the following content:

Shanxi coal was extracted with acetone, DMF, cholamine and ethylenediamine by soxhlet extraction and stirring extraction, resp. With ethylenediamine as the solvent and using simple stirring extraction, the extraction yield was up to 17.1%. A gas chromatog.-mass spectrometry (GC/MS) method for determination of ethylenediamine extracts and cholamine extracts was developed. The results showed that 53 organic species were identified from the ethylenediamine extracts, and they can be classified into four groups components: arenes, aliphatic hydrocarbons, nitrogen compounds and oxygen compounds The nitrogen compounds are the most abundant compounds of which relative contents of area normalization is 75.64%. Compared with the detected species of ethylenediamine extracts, the detected species of cholamine extract is less, and the components of cholamine extract are different from that of ethylenediamine extract The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Related Products of 34413-35-9

The Article related to solvent extract coal gas chromatog mass spectrometry, coal role: amx (analytical matrix), anst (analytical study), gas chromatography-mass spectrometry role: pep (physical, engineering or chemical process), prp (properties), proc (process), solvent extraction role: pep (physical, engineering or chemical process), prp (properties), proc (process) and other aspects.Related Products of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Vitzthum, O. G.; Werkhoff, P.; Hubert, P. published an article in 1975, the title of the article was Volatile components of roasted cocoa. Basic fraction.Category: quinoxaline And the article contains the following content:

Roasted cocoa volatiles were isolated using the following technique:extraction with supercritical CO2 under pressure followed by atm. steam distillation; adsorption on Porapak Q and subsequent extraction with purified diethylether; separation of the organic phase into basic and neutral fractions. Identification of basic cocoa aroma constituents was accomplished by mass spectrometry in combination with a 200m × 0.31 mm i.d. glass capillary column. For the 1st time 59 compounds are reported in roasted cocoa including alkyl-, alkenyl, acyl-, furyl- and alicyclic pyrazines, pyridines, quinoxalines, oxazoles, quinoline [91-22-5] and methyl o-aminobenzoate [134-20-3]. The CO2-extraction process described is generally applicable to studies on volatile aroma constituents in food odor research. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Category: quinoxaline

The Article related to cocoa volatile compound, flavor compound cocoa, Foods: Vegetable Origin and other aspects.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On January 24, 2019, Tangherlini, Giovanni; Kalinin, Dmitrii V.; Schepmann, Dirk; Che, Tao; Mykicki, Nadine; Staender, Sonja; Loser, Karin; Wuensch, Bernhard published an article.COA of Formula: C8H10N2 The title of the article was Development of novel quinoxaline-based κ-opioid receptor agonists for the treatment of neuroinflammation. And the article contained the following:

Neuroinflammatory disorders, such as multiple sclerosis or exptl. autoimmune encephalomyelitis (EAE), an established mouse model mimicking part of the human pathol., are characterized by inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells, which cause demyelination and neurodegeneration. Disease onset and perpetuation are mediated by peripherally generated autoreactive T cells infiltrating into the central nervous system, where they are restimulated by antigen-presenting cells. Here, we show that newly designed peripherally active, potent, and selective κ-opioid receptor (KOR) agonists comprising the ethylenediamine KOR pharmacophore in a perhydroquinoxaline scaffold exhibit potent anti-inflammatory capacities in primary antigen presenting cells as well as T cells. In the EAE model, the secondary amine I and the triazole II were able to ameliorate disease severity and to delay disease onset by blocking effector T cell activation. Importantly, the beneficial effects were mediated via signaling through KOR because off-target effects were excluded by using KOR-deficient mouse mutants. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to quinoxaline kappa opioid receptor agonist neuritis antiinflammatory multiple sclerosis, anti multiple sclerosis immunomodulator, Pharmacology: Structure-Activity and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Rychen, Guido; Aquilina, Gabriele; Azimonti, Giovanna; Bampidis, Vasileios; Bastos, Maria de Lourdes; Bories, Georges; Cocconcelli, Pier Sandro; Flachowsky, Gerhard; Gropp, Juergen; Kolar, Boris; Kouba, Maryline; Lopez Puente, Secundino; Lopez-Alonso, Marta; Mantovani, Alberto; Mayo, Baltasar; Ramos, Fernando; Saarela, Maria; Villa, Roberto Edoardo; Wallace, Robert John; Wester, Pieter; Brantom, Paul; Dusemund, Birgit; Hogstrand, Christer; Van Beelen, Patrick; Westendorf, Johannes; Gregoretti, Lucilla; Manini, Paola; Chesson, Andrew; EFSA Panel on Additives and Products or Substances used in Animal Feed published an article in 2017, the title of the article was Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species.Electric Literature of 34413-35-9 And the article contains the following content:

A review. Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 22 compounds belonging to chem. group 24 (pyrazine derivatives). They are currently authorised as flavours in food. The FEEDAP Panel concludes that: 2,3-diethylpyrazine [14.005], 2-ethyl-3-methylpyrazine [14.006], 5,6,7,8-tetrahydroquinoxaline [14.015], 2,3,5,6-tetramethylpyrazine [14.018], 2,3,5-trimethylpyrazine [14.019], 2,5-dimethylpyrazine [14.020], 2,6-dimethylpyrazine [14.021], 2-ethylpyrazine [14.022], 2-ethyl-3,5-dimethylpyrazine [14.024], 2,5 or 6-methoxy-3-methylpyrazine [14.025], 2-methylpyrazine [14.027], acetylpyrazine [14.032], 6,7-dihydro-5-methyl-5H-cyclopenta(b)pyrazine [14.037], 2-isobutyl-3-methoxypyrazine [14.043], 2-acetyl-3-ethylpyrazine [14.049], 2,3-dimethylpyrazine [14.050], 2,3-diethyl-5-methylpyrazine [14.056], 2-(sec-butyl)-3-methoxypyrazine [14.062], 3,(5- or 6-)-dimethyl-2-ethylpyrazine [14.100], 2-ethyl-3-methoxypyrazine [14.112] and 2-methoxy-3-methylpyrazine [14.126] are safe at the proposed maximum dose level (0.5 mg/kg complete feed) as feed for cattle, salmonids and non-food-producing animals, and at the proposed normal use level of 0.1 mg/kg complete feed for pigs and poultry; 5-methylquinoxaline [14.028] are safe only at concentrations below the proposed use levels (0.08 mg/kg complete feed for cattle, salmonids and non-food-producing animals, and 0.05 mg/kg complete feed for pigs and poultry). No safety concern would arise for the consumer from the use of these compounds up to the highest proposed level in feeds. Hazards for skin and eye contact, and respiratory exposure are recognized for the majority of the compounds under application. Most are classified as irritating to the respiratory system. The proposed maximum use levels in feed are unlikely to have detrimental effects on the terrestrial and fresh water compartments. Because all the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Electric Literature of 34413-35-9

The Article related to review safety efficacy pyrazine derivative, chemical group 24, pyrazine derivatives, safety, sensory additives, Food and Feed Chemistry: Reviews and other aspects.Electric Literature of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On April 30, 2002, Adams, T. B.; Doull, J.; Feron, V. J.; Goodman, J. I.; Marnett, L. J.; Munro, I. C.; Newberne, P. M.; Portoghese, P. S.; Smith, R. L.; Waddell, W. J.; Wagner, B. M. published an article.Formula: C8H10N2 The title of the article was The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. And the article contained the following:

A review. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicol. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to review pyrazine flavor gras, Food and Feed Chemistry: Reviews and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Malone, J. P.; McGimpsey, H. C. published an article in 1977, the title of the article was Fungicidal control of foliar diseases of barley in Northern Ireland.Formula: C8H10N2 And the article contains the following content:

Trials were carried out during 1971-74 in which 5 barley cultivars and 9 fungicides were employed for the control of mildew (Erysiphe graminis) and leaf blotch (Rhynchosporium secalis). The highest level of mildew was recorded in 1973 and of leaf blotch in 1972. All of the treatments used in 1973 reduced the level of mildew and several of them the level of leaf senescence, the best result being obtained with tridemorph [24602-86-6]. The treatment also increased grain yield and thousand (M) grain weight (benomyl [17804-35-2] and chlorquinox [9004-32-4] by ∼10%) but the differences between treatments were not significant. When the level of mildew was low, it was reduced by ethirimol [23947-60-6] seed treatment in 1971 and by all the treatments in 1974, but this did not significantly affect yield or M weight In 1971 and 1972 benomyl reduced the level of leaf blotch and in 1972 the level of leaf senescence. It also increased M weight in 1971, and both yield and M weight in 1972. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to barley erysiphe rhynchosporium fungicide, Agrochemicals: Microbial and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Folkes, D. J.; Gramshaw, J. W. published an article in 1977, the title of the article was Volatile constituents of white bread crust.Product Details of 34413-35-9 And the article contains the following content:

A total of 190 volatile components were identified in essences prepared from white bread crust (in 20 cases the identification is provisional); of these compounds 97 have not previously been reported as constituents of white bread. A limited number only, of the compounds reported, may be partially responsible for the crusty notes present in bread aroma. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Product Details of 34413-35-9

The Article related to bread crust odor, Foods: Vegetable Origin and other aspects.Product Details of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider