Category: 34413-35-9

On April 30, 2011, Khanafari, A.; Olia, M. Seyed Jafari; Sharifnia, F. published an article.SDS of cas: 34413-35-9 The title of the article was Bioconversion of essential oil from plants with eugenol bases to vanillin by Serratia marcescens. And the article contained the following:

Essential oils extraction from native or collective plants with eugenol basses such as Eugenia caryophyllata and Ocimum basilicum and bio-transformation to vanillin by Serratia marcescens (ATCC 13880) was investigated. The oils were obtained by steam distillation and were analyzed by UV and GC-MS. Essential oils with eugenol bases was added to resting phase of bacterium growth curve with final concentration of 20 gL-1 and incubated at 27°C and 150 rpm, for 24 h to bioconversion to vanillin. Crystalline structure of vanillin was isolated and confirmed by GC-MS. Forthy-three and one hundred and fifteen compounds were identified in essential oil of Eugenia caryopyllata by using first and second methods and eugenol was determined as the major component with 88.205 % and 54.628 % resp. Eugenol in essential oil of Ocimum basilicum was rare. The highest vanillin concentration, 0.6 gL-1, was obtained with 46 % purity from flower buds of Eugenia caryopyllata. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).SDS of cas: 34413-35-9

The Article related to eugenia ocimum essential oil eugenol vanillin serratia bioconversion, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.SDS of cas: 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 21, 1995, Ellis, Michael J.; Lloyd, Douglas; McNab, Hamish; Walker, Marion J. published an article.Formula: C8H10N2 The title of the article was Gas-phase pyrolysis of 2,3-dihydro-1,4-diazepines: involvement of the saturated portion of the ring in chemical reactions and novel cis-trans isomerization of a fused ring system. And the article contained the following:

Flash vacuum pyrolysis of 2,3-dihydro-1,4-diazepines in the range 450-550 °C involves interaction of the saturated portion of the mol. with the vinamidine system and causes 1,5-hydrogen shifts which have been established by deuterium labeling experiments; at higher temperatures, ring contraction occurs to give pyrazines as major products. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to isomerization pyrolysis dihydrodiazepine, ring contraction pyrolysis dihydrodiazepine, hydrogen shift pyrolysis dihydrodiazepine, mechanism pyrolysis dihydrodiazepine, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On March 23, 2017, Soeberdt, Michael; Molenveld, Peter; Storcken, Roy P. M.; Bouzanne des Mazery, Renaud; Sterk, Geert Jan; Autar, Reshma; Bolster, Marjon G.; Wagner, Clemens; Aerts, Sebastianus N. H.; van Holst, Frank R.; Wegert, Anita; Tangherlini, Giovanni; Frehland, Bastian; Schepmann, Dirk; Metze, Dieter; Lotts, Tobias; Knie, Ulrich; Lin, Kun-Yuan; Huang, Tai-Yu; Lai, Chih-Ching; Staender, Sonja; Wuensch, Bernhard; Abels, Christoph published an article.Quality Control of 5,6,7,8-Tetrahydroquinoxaline The title of the article was Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo. And the article contained the following:

In order to develop novel κ agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4aR,5S,8aS)-configured decahydroquinoxalines was developed. Physicochem. and pharmacol. properties were fine-tuned by structural modifications in the arylacetamide and amine part of the pharmacophore as well as in the amine part outside the pharmacophore. The decahydroquinoxalines show single-digit nanomolar to subnanomolar κ-opioid receptor affinity, full κ agonistic activity in the [35S]GTPγS assay, and high selectivity over μ, δ, σ1, and σ2 receptors as well as the PCP binding site of the NMDA receptor. Several analogs were selective for the periphery. The anti-inflammatory activity of decahydroquinoxalines after topical application was investigated in two mouse models of dermatitis. The methanesulfonamide I containing the (S)-configured hydroxypyrrolidine ring was identified as potent (Ki = 0.63 nM) and highly selective, κ agonist (EC50 = 1.8 nM) selective for the periphery with dose-dependent anti-inflammatory activity in acute and chronic skin inflammation. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Quality Control of 5,6,7,8-Tetrahydroquinoxaline

The Article related to decahydroquinoxaline stereoselective preparation opioid receptor agonistic antiinflammatory activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On July 1, 2016, Huang, Wen-Xue; Liu, Lian-Jin; Wu, Bo; Feng, Guang-Shou; Wang, Baomin; Zhou, Yong-Gui published an article.Safety of 5,6,7,8-Tetrahydroquinoxaline The title of the article was Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides. And the article contained the following:

A facile method has been developed for the synthesis of chiral piperazines through Ir-catalyzed hydrogenation of pyrazines activated by alkyl halides, giving a wide range of chiral piperazines including 3-substituted as well as 2,3- and 3,5-disubstituted ones with up to 96% ee. The high enantioselectivity, easy scalability, and concise drug synthesis demonstrate the practical utility. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Safety of 5,6,7,8-Tetrahydroquinoxaline

The Article related to pyrazine alkyl halide iridium chiral ligand hydrogenation catalyst, piperazine stereoselective preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 27, 2006, Leclerc, Jean-Philippe; Fagnou, Keith published an article.Application of 34413-35-9 The title of the article was Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides. And the article contained the following:

Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst;. The resulting products can be deoxygenated in high yield or further functionalized by making use of the N-oxide functionality. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Application of 34413-35-9

The Article related to diazine oxide aryl halide cross coupling palladium, aryldiazine oxide preparation deoxygenation, aryl diazine preparation, palladium cross coupling catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On August 31, 2000, Manoharan, Mariappan; De Proft, Frank; Geerlings, Paul published an article.Name: 5,6,7,8-Tetrahydroquinoxaline The title of the article was A computational study of aromaticity-controlled Diels-Alder reactions. And the article contained the following:

The prime role of aromaticity in Diels-Alder reactions is studied computationally by ab initio and DFT methods using various masked dienes and ethylene. The reactions under consideration yield both aromatic stabilized and destabilized products through a concerted transition state due to the effect of ring functions embedded in the diene framework. Computations reveal that the cycloadditions involving various quinodimethanes achieve a progressive aromaticity gain during the reaction by the influence of aromatic functionalization; therefore they are kinetically as well as thermodynamically much more favorable than the typical butadiene-ethylene reaction. A series of these reactions affirms that the degree of aromatization increases with decreasing barrier and increasing exothermicity of a reaction. In reactions of benzo[c]heterocycles, aromaticity is lost due to the reacting heterocycle, but is gained by the adjacent hexagon during the reaction course. A partly occurring aromatic stabilization process in these reactions seems to facilitate the cycloaddition, but the remaining aromatic destabilization decreases the reaction rate and energy as compared to quinodimethane reactions. In the reactions of polyaromatic hydrocarbons viz. styrene, anthracene and pentacene, only loss of aromaticity occurs by virtue of aromatic defunctionalization. The progress of aromatization as well as dearomatization is evidenced from the nucleus independent chem. shifts (NICS) values whereas the aromaticity of the transition state and product is quantified by magnetic susceptibility exaltation (MSE) calculations Calculations thus establish with both magnetic and energetic criteria that the aromatic stabilization process as well as the aromatic ring function of the masked diene accelerates the reaction to the maximum extent through an ‘early’ TS, but the aromatic destabilization deactivates the cycloaddition via a ‘late’ TS. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Name: 5,6,7,8-Tetrahydroquinoxaline

The Article related to dft diels alder aromatization magnetic susceptibility, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Name: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 17, 2000, Manoharan, Mariappan; De Proft, Frank; Geerlings, Paul published an article.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline The title of the article was Enhanced Aromaticity of the Transition Structures for the Diels-Alder Reactions of Quinodimethanes: Evidence from ab Initio and DFT Computations. And the article contained the following:

The Diels-Alder reactions of various quinodimethanes with ethylene are studied by means of ab initio MO and d. functional theory (DFT) to show the effect of aromaticity on the reaction path. The calculations reveal that these reactions are both kinetically and thermodynamically much more favored than the prototype butadiene-ethylene Diels-Alder reaction due to the aromatization process in the transition state (TS) and product. A progressive aromaticity gain is noticed during the reaction, and hence the partial π-delocalized peripheral diene ring function is coupled with the six-electron σ,π-delocalized cyclic unit resulting in an enhanced aromaticity of the TS. The magnetic criteria such as magnetic susceptibility exaltation and nucleus independent chem. shift provide definitive evidence for and fully support the aromatization process and the aromaticity of the TS. The extent of σ-π delocalization and the bond make-break at the TS are consistent with each other, and this is strongly influenced by the adjacent π-aromatization process. Moreover, the aromaticity trends in the resulting TSs and products parallel the activation and reaction energies; the extent of aromatization increases with increasing reaction rate and exothermicity. This confirms that aromaticity is the driving factor governing cycloadditions involving quinodimethanes. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

The Article related to aromaticity transition state diels alder quinodimethane ab initio dft, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On September 28, 2020, Gong, Yu; Li, Zhi-Hua; Yan, Xiaodong; Wang, Ya-Qin; Zhao, Chen-Yang; Han, Wang-Kang; Hu, Qing-Tao; Lu, Hui-Shu; Gu, Zhi-Guo published an article.Application of 34413-35-9 The title of the article was Bivariate Metal-Organic Frameworks with Tunable Spin-Crossover Properties. And the article contained the following:

In this work, pyrazine (A), aminopyrazine (B), quinoxaline (C), and 5,6,7,8-tetrahydroquinoxaline (D) have been screened out among a large number of pyrazine derivatives to construct Hofmann-type metal-organic frameworks (MOFs) Fe(L)[M(CN)4] (M=Pt, Pd) with similar 3D pillared-layer structures. X-ray single-crystal diffraction reveals that the alternate linkage between M and FeII ions through cyano bridges forms the 2D extended metal cyanide sheets, and ligands A-D acted as vertical columns to connect the 2D sheets to give 3D pillared-layer structures. Subsequently, a series of bivariate MOFs were constructed by pairwise combination of the four ligands A-D, which were confirmed by 1H NMR, PXRD, FTIR, and Raman spectroscopy. The results demonstrated that ligand size and crystallization rate play a dominant role in constructing bivariate Hofmann-type MOFs. More importantly, the spin-crossover (SCO) properties of the bivariate MOFs can be finely tuned by adjusting the proportion of the two pillared ligands in the 3D Hofmann-type structures. Remarkably, the spin transition temperatures, Tc↑ and Tc↓ of Fe(A)x(B)1-x[Pt(CN)4] (x=0 to 1) can be adjusted from 239 to 254 K and from 248 to 284 K, resp. Meanwhile, the width of the hysteresis loops can be widened from 9 to 30 K. Changing Pt to Pd, the hysteresis loops of Fe(A)x(B)1-x[Pd(CN)4] can be tuned from 9 (Tc↑=215 K, Tc↓=206 K) to 24 K (Tc↑=300 K, Tc↓=276 K). This research provides wider implications in the development of advanced bistable materials, especially in precisely regulating SCO properties. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Application of 34413-35-9

The Article related to iron pyrazine quinoxaline platinum palladium cyano mof preparation, spin crossover iron pyrazine quinoxaline platinum palladium cyano mof, thermal stability iron pyrazine quinoxaline platinum palladium cyano mof, crystal structure iron pyrazine quinoxaline platinum palladium cyano mof, hofmann, bivariate, hysteresis loops, metal-organic frameworks, spin-crossover and other aspects.Application of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 17, 2000, Manoharan, Mariappan; De Proft, Frank; Geerlings, Paul published an article.Electric Literature of 34413-35-9 The title of the article was Enhanced Aromaticity of the Transition Structures for the Diels-Alder Reactions of Quinodimethanes: Evidence from ab Initio and DFT Computations. And the article contained the following:

The Diels-Alder reactions of various quinodimethanes with ethylene are studied by means of ab initio MO and d. functional theory (DFT) to show the effect of aromaticity on the reaction path. The calculations reveal that these reactions are both kinetically and thermodynamically much more favored than the prototype butadiene-ethylene Diels-Alder reaction due to the aromatization process in the transition state (TS) and product. A progressive aromaticity gain is noticed during the reaction, and hence the partial π-delocalized peripheral diene ring function is coupled with the six-electron σ,π-delocalized cyclic unit resulting in an enhanced aromaticity of the TS. The magnetic criteria such as magnetic susceptibility exaltation and nucleus independent chem. shift provide definitive evidence for and fully support the aromatization process and the aromaticity of the TS. The extent of σ-π delocalization and the bond make-break at the TS are consistent with each other, and this is strongly influenced by the adjacent π-aromatization process. Moreover, the aromaticity trends in the resulting TSs and products parallel the activation and reaction energies; the extent of aromatization increases with increasing reaction rate and exothermicity. This confirms that aromaticity is the driving factor governing cycloadditions involving quinodimethanes. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Electric Literature of 34413-35-9

The Article related to aromaticity transition state diels alder quinodimethane ab initio dft, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Electric Literature of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

He, Yuqin; Zhang, Haide; Wen, Nana; Hu, Rongsuo; Wu, Guiping; Zeng, Ying; Li, Xiong; Miao, Xiaodan published an article in 2018, the title of the article was Effects of maltose and lysine treatment on coffee aroma by flash gas chromatography electronic nose and gas chromatography-mass spectrometry.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

BACKGROUND : Arabica coffee is a sub-tropical agricultural product in China. Coffee undergoes a series of thermal reactions to form abundant volatile profiles after roasting, so it loses a lot of reducing sugars and amino acids. Adding carbonyl compounds with amino acids before roasting could ensure the nutrition and flavor of coffee. The technol. is versatile for the development of coffee roasting process. This investigation evaluates the effects of combining maltose and lysine (Lys) to modify coffee aroma and the possibly related mechanisms. Arabica coffee was pretreated with a series of solvent ratios of maltose and Lys with an identical concentration (0.25 mol L-1) before microwave heating. RESULTS : It was found that the combination of maltose and Lys significantly (P ≤ 0.05) influenced quality indexes of coffee (pH and browning degree). Ninety-six aromatic volatiles have been isolated and identified. Twelve volatile profiles revealed the relationship between fragrance difference and compound content in coffee. Moreover, coffee aroma was modified by a large number of volatiles with different chem. classes and character. CONCLUSION : Thus, our results suggest that the combination of reagents changed overall aroma quality through a series of complex thermal reactions, especially the ratio of Lys/maltose over 2:1. © 2017 Society of Chem. Industry. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

The Article related to coffee aroma maltose lysine flash gas chromatog electronic nose, maillard reaction, coffee, electronic nose, lysine, solid-phase microextraction-gas chromatography-mass spectrometry (spme-gc-ms) and other aspects.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider