Category: 36856-91-4

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Preparation of compound 2a A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline (100 mg, 0.48 mmol), 4- Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane (1.0 mL/4.0 ml), K2C03 (132 mg, 0.96 mmol). The resulting solution was degassed for 15 min, then Pd(PPh3)4 (27 mg, 0.024 mmol) was added. The reaction mixture was warmed to 100 C and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHC03, brine, dried over Na2S04. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with EtOAc hexanes solvent system afforded the desired compound (40 mg, 38% yield). NMR (400 MHz, CDC13) delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25 (m, 1H).

36856-91-4, The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; PARHI, Ajit; PILCH, Daniel, S.; KAUL, Malvika; WO2013/106756; (2013); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

Under nitrogen protection,The diprazole pyrene intermediate 100 mmol,2-bromoquinoxaline 223 mmol,Tris (dibenzylideneacetone) dipalladium 5.0 mmol,Sodium tert-butoxide,Tri-tert-butylphosphine (20.1 mmol) was placed in a reaction vessel,And dissolved in 500 ml of toluene,110 reflux reaction 24h,The reaction end point was determined by thin layer chromatography (TLC)After completion of the reaction, the mixture was cooled to room temperature, passed through a silica gel funnel, washed with methylene chloride, spin dried, recrystallized from dichloromethane / petroleum ether,After drying, 81 mmol of compound 15 was obtained in 81% yield.

36856-91-4, As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Keliente Chemical Materials Co., Ltd.; Yin Enxin; Lin Wenjing; (17 pag.)CN104262347; (2017); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under the protection of nitrogen,Weighing compound S5 (15 mmol), S17 (15 mmol), [Pd2(dba)3]¡¤CHCl3(0.3 mmol) and HP(tBu)3¡¤BF4 (0.6 mmol),Add to a 100 mL two-necked flask.Inject 30 mL of toluene into the two-necked flask (pre-pass N2 for 15 min to remove oxygen).Then, 3.6 mL of a 1 M aqueous solution of K2CO3 (previously passed N2 for 15 min to remove oxygen) was added dropwise, and stirred at room temperature overnight.After the reaction was over, 50 mL of deionized water was added.Then add a few drops of 2M HCl. Extract with dichloromethane.Collect organic phase,It was dried over anhydrous Na2SO4.Filter the dried solution,The solvent was removed using a rotary evaporator to give a crude material.The crude product was purified by silica gel column chromatography.Final purification gave solid P4 (13.2 mmol, 88%)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Gao Wei; Wang Xiangcheng; Zhang Lei; Niu Jinghua; (47 pag.)CN108358905; (2018); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

c. Preparation of compound 6c A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline (13 mg, 0.063 mmol), boronate ester 6b (25 mg, 0.063 mmol), water/dioxane (1.0 mL/4.0 ml), K2C03 (17 mg, 0.126 mmol). The resulting solution was degassed for 15 min, then Pd(PPh3)4 (5 mg) was added. The reaction mixture was warmed to 100C and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHC03, brine, dried over Na2S04. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with 10 % EtOAc/hexanes solvent system afforded the desired compound (15 mg, 60 % yield) . 1H NMR (300 MHz, CDC13) delta 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H), 8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J =12.0 Hz, 2H), 7.58 (d, J= 12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H).

36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; PARHI, Ajit; PILCH, Daniel, S.; KAUL, Malvika; WO2013/106756; (2013); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen inloutlet adapter was charged with 2-bromoquinoxaline (100 mg, 0.48 mmol),4-Fluorophenylboronic acid (80 mg, 0.57 mmol), water dioxane (1.0 mL4.0 ml), K2C03 (132 mg, 0.96 mmol). The resulting solution was degassed for 15 mm, then Pd(PPh3)4 (27 mg, 0.024 mmol) was added. The reaction mixture was warmed to 100 C. and stirred for 1 h. Afier cooled to roomtemperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHCO3, brine, dried over Na2504. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with EtOAc hexanes solvent system afforded the desired compound (40mg, 38% yield). 1H NMR (400 MHz, CDCl3) oe 9.34 (s, 1H),8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25 (m, 1H)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Rutgers, The State University of New Jersey; LaVoie, Edmond J.; Parhi, Ajit; Pilch, Daniel S.; Kaul, Malvika; (36 pag.)US9822108; (2017); B2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

36856-91-4, 2-bromoquinoxaline 100mmol, eight membered nitrogen (or sulfur) heterocyclic boride intermediate 220mmol were added to 1L three-necked flask and dissolved in 400mL of toluene, was added under nitrogen tetrakistriphenylphosphine palladium 1.5mmol, 250mmol potassium carbonate, distilled water 100mL, the reaction was stirred at reflux for 24 hours, cooled to room temperature, after the reaction liquid separation, silica gel funnel, washing, spin-dry, recrystallized, filtered, 71mmol obtain compound 17 as a gray solid, yield 71%.

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Ma, Xiaoyu; Song, Qiaohong; Zhao, He; (22 pag.)CN105315229; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with2-bromoquinoxaline (13 mg, 0.063 mmol), 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-carbomethoxy-4?-(t-butyl)phenyl-[1,1?]biphenyl (25 mg, 0.063mmol), water/dioxane (1.0 mL/4.0 ml), K2CO3 (17 mg, 0.126mmol). The resulting solution wasdegassed for 15 min, then Pd(PPh3)4 (5 mg) wasadded. The reaction mixture was warmedto 100oC and stirred for 1 h.After cooled to room temperature, the reaction mixture was diluted withEtOAc and washed with saturated NaHCO3, brine, dried over Na2SO4.The organic layer was concentrated in rotavapor and purified on silicagel. Elution with 10 % EtOAc/hexanessolvent system afforded the desired compound (15 mg, 60 % yield) . 1HNMR (300 MHz, CDCl3) delta 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H),8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J =12.0 Hz, 2H), 7.58 (d, J= 12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H).

36856-91-4, The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Bromoquinoxaline 50 (350 mg, 1.67 mmol, 1 eq) was dissolved in EtOAc (16 ml). Octanal (1.05 ml,6.715 mmol, 4 eq) and TMSN3 (0.44 ml, 6.698 mmol, 2 eq) were added. Phi(OCOCF3)2 (1.44 g, 6.698mmol, 2 eq) was added portionwise over 10 min and the mixture turned orange in colour. The mixturewas stirred at room temperature for 2 h. Further TMSN3 (0.44 ml, 6.698 mmol, 2 eq) and Phi(OCOCF3)220 (1.44 g, 6.698 mmol, 2 eq) were added and reaction was stirred for 18 h. Triethylamine (2 ml) was addeddropwise and the mixture was stirred for 15 min. The reaction mixture was concentrated and the crudemixture was purified by silica gel column chromatography (50:1 pentane: EtOAc) to afford product 51 as ayellow solid (259 mg, 61%). Rt = 0.38 (10:1 cyclohexane: EtOAc); m.p. = 43-48 oc; 1H NMR (400 MHz,CDCI3) o 8.16-8.04 (m, 2H), 7.90-7.81 (m, 2H), 3.18 (t, J = 7.5 Hz, 2H), 1.83-1.75 (m, 2H), 1.44-25 1.28 (m, 8H), 0.89 (t, J = 7.0 Hz, 3H); 13C NMR (101 MHz, CDCI3) o 201.5, 149.8, 143.3, 139.6, 134.8,132.6, 131.2, 129.8, 128.61, 40.7, 31.8, 29.3, 29.2, 23.7, 22.8, 14.2; IR (CHCI3) (vmax, cm-1) 3429, 1708,1560; HRMS (ESI) [M + Hf calc 335.0759 for C16H20N20 79Br, found 335.0759., 36856-91-4

The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY COLLEGE DUBLIN; GUIRY, Patrick; GODSON, Catherine; (148 pag.)WO2018/33642; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline(100 mg, 0.48 mmol), 4-Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane(1.0 mL/4.0 ml), K2CO3 (132 mg, 0.96 mmol). The resulting solution was degassed for 15min, then Pd(PPh3)4 (27mg, 0.024 mmol) was added. Thereaction mixture was warmed to 100 oC and stirred for 1 h. After cooled to room temperature, thereaction mixture was diluted with EtOAc and washed with saturated NaHCO3,brine, dried over Na2SO4. The organic layer wasconcentrated in rotavapor and purified on silica gel. Elution with EtOAc/hexanes solvent systemafforded the desired compound (40 mg, 38% yield). 1H NMR (400 MHz, CDCl3)delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25(m, 1H).

36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mE round bottom flask equipped with a magneticstirrer, a condenser and a nitrogen inoutlet adapter was charged with 2-bromoquinoxaline (13 mg, 0.063 mmol), boronate ester 6b (25 mg, 0.063 mmol), water/dioxane (1.0 mE/4.0 ml), K2C03 (17 mg, 0.126 mmol). The resulting solution was degassed for 15 mm, then Pd(PPh3)4 (5 mg)was added. The reaction mixture was warmed to 1000 C. and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHCO3, brine, dried over Na2SO4. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with 10% EtOAc/hexanes solvent system afforded the desired compound (15 mg, 60% yield).1H NMR (300 MHz, CDCl3) oe 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H), 8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J=12.0 Hz, 2H), 7.58 (d, J=12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Rutgers, The State University of New Jersey; LaVoie, Edmond J.; Parhi, Ajit; Pilch, Daniel S.; Kaul, Malvika; (36 pag.)US9822108; (2017); B2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider