Category: 36856-91-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

To a stirred mixture of N-[(dimethylamino)methylidene]-4-[fra ,-2-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)cyclopropyl]benzenesulfonamide (Intermediate 12) (30 mg, 0.079 mmol) and 2-bromoquinoxaline (29 mg, 0.139 mmol) in toluene (0.79 mL) were added cataCXium A-Pd-G2 [2′-(dimethylamino)-2-biphenyl-palladium(II)-chloride di(l-adamantyl)- ft-butylphosphine complex] (5.3 mg, 0.0079 mmol) and potassium phosphate tribasic (1 M in water, 0.24 mL, 0.24 mmol) sequentially. The resulting mixture was allowed to stir at 100 C for 18 h then allowed to cool to ambient temperature. Ethyl acetate (3 mL) and water (0.5 mL) were added and the mixture was filtered through celite. The filtrate was concentrated to remove organic solvent and the residue was treated with hydrazine hydrate (50-60%, 1 mL) and ethanol (0.5 mL), sonicated for 90 min, then concentrated to dryness. The residue was purified by preparative HPLC, eluting with a gradient of acetonitrile:water:trifluoroacetic acid – 10:90:0.1 to 95:5:0.1. The product-containing fractions were concentrated under reduced pressure to give the title compound. MS: mlz = 326.2 [M+H]. XH NMR (500 MHz, DMSO-c): delta 9.02 (s, 1 H); 8.05 (d, J= 8.3 Hz, 1 H); 8.00 (d, J= 8.3 Hz, 1 H); 7.83 (m, 1 H); 7.82-7.70 (m, 3 H); 7.45 (d, J Hz, 2 H); 7.30 (s, 2 H); 2.86 (m, 1 H); 2.74 (m, 1 H); 1.97 (m, 1 H); 1.78 (m, 1 H)., 36856-91-4

36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; CROWLEY, Brendan, M.; BELL, Ian, M.; HARVEY, Andrew John; SHIPE, William, D.; LEAVITT, Kenneth, J.; SANDERS, John, M.; GUIADEEN, Deodial, G.; SUEN, Linda, M.; GRESHOCK, Thomas, J.; RADA, Vanessa, L.; (75 pag.)WO2018/85171; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

The 1,10-phenanthroline trifluoroethyl ether copper (I) prepared in Example 1,In a nitrogen atmosphere,A polytetrafluoroethylene magnet was placed in the reactor,A solution of 0.36 mmol of 1,1,10-phenanthroline trifluoroethyl ether copper (I)(Phen) 2Cu (OCH2CF3),0.3 mmol of 2-bromoquinoxaline, 0.3 mmol of sodium tert-butoxide and 3 mL of N, N-dimethylformamide solvent,And heated in a closed system at 80 C for 12 h, cooled to room temperature,Extracted with 3 x 10 mL of ether, the extracts were combined and concentrated, and the resulting residue was purified by silica gel column chromatography,The eluent was treated with ether: n-pentane = 1: 5 to give 2-trifluoroethoxyquinoxaline in a yield of 92%

36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Fuzhou University; Weng, Zhi Qiang; Huang, yangjie; Huang, ronglu; Ding, jianping; (9 pag.)CN104557924; (2016); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-bromoquinoxaline (96 mg-, 0.46 mmol) , 3-3-ethynyl-4-methyl-N- (3- ( (4-methylpiperazin-l- yl)methyl) -5- (trifluoromethyl)phenyl)benzamide (174 mg, 0.42 mmol), PdCl2(PPh3)2 (15 mg, 0.021 mmol) in MeCN (10 mL) and Et3N (3 mL) in a sealable tube was added CuI (4 mg, 0.021 mmol) . The tube was sealed and heated at 90 C for 1 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting solid was absorbed onto silica gel (5 mL) and purified via automated flash chromatography (silica gel, 0 to 5% MeOH in CH2Cl2, gradient elution) to afford 4-methyl-3- (2- (quinolin- 3-yl)ethynyl) -N- (3- (trifluoromethyl)phenyl)benzamide. MS m/z = 544 [M+H]+. CaIc’d for C31H28F3N5O: 543

The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2006/44823; (2006); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider