Category: 39267-05-5

Ammar, Y. A. published the artcileSynthesis of some newer thiazolo and thiadiazino derivatives from 6-methyl- or 6-nitro-2,3-dichloroquinoxalines, HPLC of Formula: 39267-05-5, the main research area is chloroquinoxaline cyclocondensation thiourea; quinoxaline dichloro cyclocondensation thiourea; diquinoxalinodithiin; aminoiminodihydrothiazoloquinoxaline preparation cyclization carbon disulfide; thiazoloquinoxaline preparation reaction.

Interaction of 6-methyl- or 6-nitro-2,3-dichloroquinoxaline with thiourea in EtOH led to the formation of diquinoxalinodithiin derivatives I (R = Me, NO2) together with 2-imino-2,3-dihdyrothiazolo[4,5-b]quinoxalines II (R1 = H). 7-Methyl- or 7-nitro-3-amino-2-imino-2,3-dihydrothiazolo[4,5-b]quinoxalines II (R1 = NH2) were also prepared Reaction of II (R1 = NH2) with CS2 gave the corresponding 2-mercaptothiadiazine[5,6-b]quinoxaline derivatives III. Other reactions are also described.

Journal of the Indian Chemical Society published new progress about chloroquinoxaline cyclocondensation thiourea; quinoxaline dichloro cyclocondensation thiourea; diquinoxalinodithiin; aminoiminodihydrothiazoloquinoxaline preparation cyclization carbon disulfide; thiazoloquinoxaline preparation reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Obafemi, Craig A. published the artcilePermanganate oxidation of quinoxaline and its derivatives, Application In Synthesis of 39267-05-5, the main research area is permanganate oxidation quinoxaline; chloroquinoxaline permanganate oxidation; quinoxalinone permanganate oxidation; quinoxalinedione permanganate oxidation.

The oxidation reactions of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described. Neutral oxidation of 2-chloro- and 2,3-dichloroquinoxalines afforded the corresponding chloro- and dichloropyrazinedicarboxylic acids in good yield. On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alk. medium gave different products, with the quinoxalin-2(1H)-one forming 1,4-dihydroquinoxaline-2,3-dione, while various substituted quinoxalin-2,3-dione derivatives gave dimeric products.

Helvetica Chimica Acta published new progress about Oxidation. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Application In Synthesis of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kolli, Sunder Kumar published the artcileLigand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: An unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis, Related Products of quinoxaline, the main research area is thienyl pyrroloquinoxaline preparation PDE4 inhibitor apoptosis hepatotoxicity; Apoptosis; PDE4; Palladium; Pyrroloquinoxaline; Zebrafish.

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacol. properties when tested in vitro and in zebrafish embryos.

European Journal of Medicinal Chemistry published new progress about Apoptosis. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Romer, Duane R. published the artcileSynthesis and fungicidal activity of 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is quinoxaline derivative fungicide structure activity.

A series of 11 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles (I, R1 = H, Cl, CF3, MeO, CN, Ac, NO2; R2 = H, Cl Me, NO2) was prepared by reaction of 2,3-dichloroquinoxalines with disodium (Z)-2,3-dimercapto-2-butenedinitrile in N,N-dimethylformamide. These products were tested for in-vitro fungicidal activity by a Min. Inhibitory Concentration method. Several of these compounds showed broad-spectrum fungicidal activity. The activity exhibited by these compounds was greatly dependent upon the substituents of the quinoxaline ring, with the nitro-substituted derivatives showing the highest levels of antifungal activity. None of the compounds prepared, however, showed fungicidal activity comparable to that of the com. fungicides screened.

Pesticide Science published new progress about Fungicides. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Romer, Duane R. published the artcileSynthesis of 2,3-dichloroquinoxalines via Vilsmeier reagent chlorination, Product Details of C9H6Cl2N2, the main research area is quinoxaline dichloro preparation Vilsmeier reagent chlorination dihydroxyquinoxaline.

A convenient and high-yielding synthesis of 2,3-dichloroquinoxalines from the corresponding 2,3-dihydroxyquinoxalines has been developed. Treatment of a slurry of the 2,3-dihydroxyquinoxaline with N,N-dimethylformamide in the presence of excess thionylchloride in 1,2-dichloroethane results in the rapid and high-yielding formation of the 2,3-dichloroquinoxaline derivatives Simplified workup and purification procedures for these compounds are also described.

Journal of Heterocyclic Chemistry published new progress about Chlorination. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Product Details of C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ahmad, Yusuf published the artcileQuinoxaline derivatives. XI. Reaction of quinoxaline 1,4-dioxide and some of its derivatives with acetyl chloride, Formula: C9H6Cl2N2, the main research area is quinoxaline dioxide reaction; acetyl chloride reaction; chloroquinoxaline dioxide.

Quinoxaline 1,4-dioxide with AcCl gives 6-chloroquinoxaline 1-oxide (I). On heating, and progressively increasing the time of reaction, the yield of I increases, and 3-chloroquinoxaline 1-oxide, and 6.7-dichloroquinoxaline appear as addnl. products. 7-Ethoxy-, 7-methoxy-, 7-methylquinoxaline 1,4-dioxides show a similar behavior, giving corresponding 6-chloro, and 3-chloro derivatives as main products. Further increase in the reaction time results in the formation of 2,6-dichloro and 2,3-dichloro compounds as addnl. products. However, none of the 2-chloro 4-oxide derivatives were isolated. The mechanisms for these transformations were proposed and discussed.

Journal of Organic Chemistry published new progress about Chlorination. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Babu, P. Vijaya published the artcileLigand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo, Synthetic Route of 39267-05-5, the main research area is PDE4 luciferase mouth cancer cell proliferation zebrafish; pyrroloquinoxaline preparation PDE4 inhibitor; dichloroquinoxaline intramol Heck reaction.

A series of 1,3-disubstituted pyrrolo[2,3-b]quinoxalines was designed for the potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer catalyst) free intramol. Heck cyclization strategy was used to prepare these compounds, some of which showed significant inhibition of PDE4B (IC50 ≈ 5-14 μM) and growth inhibition of oral cancer cells (CAL 27) but not inhibition of luciferase in vitro. They also showed acceptable safety profiles but no apoptosis in zebrafish embryos.

Organic & Biomolecular Chemistry published new progress about Heck reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Synthetic Route of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lee, Young Bok published the artcileSynthesis, anticancer activity and pharmacokinetic analysis of 1-[(substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is preparation anticancer piperazine derivative drug bioavailability.

Based on the anticancer activity of novel quinoxalinyl-piperazine compounds, 1-[(5 or 6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives published in Bioorganic Med. Chem.2010, 18, 7966, we further explored the synthesis of 7 or 8-substituted quinoxalinyl piperazine derivatives From in vitro studies of the newly synthesized compounds using human cancer cell lines, we identified some of the 8-substituted compounds, for example 6p, 6q and 6r, which inhibited the proliferation of various human cancer cells at nanomolar concentrations Compound 6r, in particular, showed the lowest IC50 values, ranging from 6.1 to 17 nM, in inhibition of the growth of cancer cells, which is better than compound 6k (compound 25 in the reference cited above). In order to select and develop a leading compound among the quinoxaline compounds with substitutions on positions 5, 6, 7 or 8, the compounds comparable to compound 6k in in vitro cancer cell growth inhibition were chosen and their pharmacokinetic properties were evaluated in rats. In these studies, compound 6k showed the highest oral bioavailability of 83.4%, and compounds 6j and 6q followed, with 77.8% and 57.6%, resp. From the results of in vitro growth inhibitory activities and the pharmacokinetic study, compound 6k is suggested for further development as an orally deliverable anticancer drug.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sastry, C. V. Reddy published the artcileSynthesis and biological activities of some 1,5-dihydro[1,2,4]ditriazolo[4,3-a:3′,4′-c]quinoxaline-1,6-diones, HPLC of Formula: 39267-05-5, the main research area is ditriazoloquinoxalinedione preparation pharmacol; antiallergic ditriazoloquinoxalinedione preparation; antimicrobial ditriazoloquinoxalinedione preparation; antiprotozoal ditriazoloquinoxalinedione preparation; anthelmintic ditriazoloquinoxalinedione preparation; nitrodihydroditriazoloquinoxalinedione preparation antiallergic.

Title compounds I (R = H, R1 = H, Cl, Me, NO2; R = NO2, Cl, Me, OMe, R1 = NO2) were prepared and tested for their antiallergic, antimicrobial, antiprotozoal and anthelmintic activities. I (R = H, NO2, Cl, R1 = NO2) had egg albumin-induced rat passive cutaneous anaphylaxis (PCA) activity >90% at 50 mg/kg.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Allergy inhibitors. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sonawane, Yogesh A. published the artcileSynthesis of novel diphenylamine-based fluorescent styryl colorants and study of their thermal, photophysical, and electrochemical properties, Synthetic Route of 39267-05-5, the main research area is diphenylamine styryl fluorescent probe thermal stability Knoevenagel condensation.

Three novel “”Y””-shaped acceptor-π-donor-π-acceptor-type compounds were synthesized from 4,4′-(hexylimino)bis(benzaldehyde) as a donor and 2-methylthiazolo[4,5-b]quinoxaline derivatives as strong electron acceptors condensed by classical Knoevenagel condensation. Their absorption, emission, and thermal properties and electrochem. stability were investigated. It was found that the strong electron acceptor-donor chromophoric system of these compounds showed high Stokes shift, excellent thermal stability, and electrochem. reversibility. The solvatochromic behavior of these colorants was studied by using various solvents such as toluene, chloroform, Et acetate, THF, methanol, and N,N-dimethylformamide in increasing order of polarity. The dyes were characterized by means of elemental anal., 1H NMR, and mass spectrometry. Graphical abstract

Monatshefte fuer Chemie published new progress about Cyclic voltammetry. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Synthetic Route of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider