Category: 39267-05-5

Srinivas, B. published the artcileSynthesis and Antimicrobial Screening of Novel Tetrazolo Triazolo Substituted Mercapto Quinoxalines, HPLC of Formula: 39267-05-5, the main research area is thio tetrazolotriazoloquinoxaline preparation antibacterial antifungal.

A novel and convenient synthesis of 6-thio-tetrazolo[1,5-a][1,2,4]triazolo[3,4-c]quinoxalines I [R = allyl, (CH2)2Br, prop-2-yn-1-yl, Bn; R1 = R2 = H, Me; R1 = Me, R2 = H] starting from 2,3-dichloroquinoxalines was reported. The newly synthesized compounds I were screened for their in vitro anti-microbial activity against Staphylococcus aureus and Bacillus subtilis as Gram-pos. bacteria, Escherichia coli and Pseudomonas aeruginosa as Gram-neg. bacteria. Among all the synthesized compounds, compounds I [R = (CH2)2Br, R1 = R2 = H; R = (CH2)2Br, R1 = Me, R2 = H; R = (CH2)2Br, R1 = R2 = Me] showed good activity and I [R = allyl; R1 = R2 = H, Me] showed moderate activity against B. subtilis and Gram-neg. bacterial strains E. coli and P. aeruginosa. They were also evaluated for their in vitro anti-fungal potential against Candida albicans and compounds I [R = (CH2)2Br, R1 = R2 = H; R = (CH2)2Br, R1 = Me, R2 = H; R = (CH2)2Br, R1 = R2 = Me] showed appreciable activity and I [R = allyl; R1 = R2 = H] showed moderate activity against tested fungal strains C. albicans organism.

Pharma Chemica published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Alhayek, Alaa published the artcileDiscovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases, Name: 2,3-Dichloro-6-methylquinoxaline, the main research area is FDA approved inhibitor clostridia bacillus collagenase antibacterial.

In view of the worldwide antimicrobial resistance (AMR) threat, new bacterial targets and anti-infective agents are needed. Since important roles in bacterial pathogenesis have been demonstrated for the collagenase H and G (ColH and ColG) from Clostridium histolyticum, collagenase Q1 and A (ColQ1 and ColA) from Bacillus cereus represent attractive antivirulence targets. Furthermore, repurposing FDA-approved drugs may assist to tackle the AMR crisis and was addressed in this work. Here, we report on the discovery of two potent and chem. stable bacterial collagenase inhibitors: synthesized and FDA-approved diphosphonates and hydroxamates. Both classes showed high in vitro activity against the clostridial and bacillary collagenases. The potent diphosphonates reduced B. cereus-mediated detachment and death of cells and Galleria mellonella larvae. The hydroxamates were also tested in a similar manner; they did not have an effect in infection models. This might be due to their fast binding kinetics to bacterial collagenases.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Name: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Obafemi, Craig A. published the artcileSynthesis and some reactions of 3-chloro-2-(cyanomethylene)-1,2-dihydroquinoxalines, Application In Synthesis of 39267-05-5, the main research area is dichloroquinoxaline malononitrile substitution; chloroquinoxaline cyanomethylene preparation.

2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and Et cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene)-1,2-dihydroquinoxaline derivatives, e.g., I. The reaction of 3-chloro-2-(dicyanomethylene)-1,2-dihydroquinoxaline (I) with pyridine and its Me derivatives led to zwitterionic structures, e.g., II. The structures of the newly synthesized compounds were assigned by spectroscopic data and elemental analyses.

Molecules published new progress about Substitution reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Application In Synthesis of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Henen, Morkos A. published the artcile[1,2,4]Triazolo[4,3-a]quinoxaline: synthesis, antiviral, and antimicrobial activities, Quality Control of 39267-05-5, the main research area is triazoloquinoxaline bioisostere pyrimidotriazoloquinoxaline preparation antibacterial antifungal antiviral agent.

Several novel [1,2,4]triazolo[4,3-a]quinoxaline derivatives and their isosteres, pyrimidine-quinoxaline derivatives [i.e., Pyrimido[1′,2′:1,5][1,2,4]triazolo[4,3-a]quinoxaline derivatives] were designed as potential antiviral and antimicrobial agents and the synthesis of the target compounds was achieved using 4-chloro-8-methyl[1,2,4]triazolo[4,3-a]quinoxalin-1-amine as a key intermediate in an an aromatic nucleophilic substitution with different amines or triazolethiol. Some of the title compounds were subjected to an in-vitro antiviral and cytotoxicity screening by a plaque-reduction assay method. Most of the tested compounds exhibited cytotoxicity at a concentration 160 μg/mL and one compound displayed promising antiviral activity. In-vitro antimicrobial screening against different pathogenic organisms using an agar diffusion method demonstrated that several compounds also exhibited antibacterial and/or antifungal activities.

Medicinal Chemistry Research published new progress about Anti-infective agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Quality Control of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Noorulla, S. Md. published the artcileSynthesis of certain substituted quinoxaline as antiinflammatory agents, Safety of 2,3-Dichloro-6-methylquinoxaline, the main research area is quinoxaline preparation antiinflammatory agent.

Substituted quinoxaline have received considerable attention during last two decades as they are endowed with variety of biol. activities and have wide range of therapeutic properties. A literature survey indicates that quinoxaline derivatives possess different pharmacol. and biol. activities, of which the most potent is anti-inflammatory activity. In view of above literature survey, the authors thought to synthesize a novel substituted quinoxaline system. An example compound thus prepared and evaluated was an isoniazid hydrazide (I) [i.e., 4-pyridinecarboxylic acid 2-[7-methyl-3-[2-[(2,4-dichlorophenyl)methylene]hydrazinyl]-2-quinoxalinyl]hydrazide derivatives, isoniazid quinoxaline Schiff base derivative]. The synthesis of the target compounds was achieved by a condensation of 4-pyridinecarboxylic acid hydrazide (i.e., isoniazid) with 2-chloro-2-[(phenylmethylene)hydrazinyl]quinoxaline derivatives

International Journal of Research in Pharmacy and Chemistry published new progress about Anti-inflammatory agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Safety of 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sun, Huikai published the artcileFirst-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson’s Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is Parkinson’s disease GPR6 inverse agonists GPCR D2R motor.

Parkinson’s disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor (GPCR) with highly restricted expression in dopamine receptor D2-type medium spiny neurons (MSNs) of the indirect pathway, a striatal brain circuit which shows aberrant hyperactivity in PD patients. Potent and selective GPR6 inverse agonists (IAG) were developed starting from a low-potency screening hit (EC50 = 43μM). Herein, we describe the multiple parameter optimization that led to the discovery of multiple nanomolar potent and selective GPR6 IAG, including our clin. compound CVN424 (I). GPR6 IAG reversed haloperidol-induced catalepsy in rats and restored mobility in the bilateral 6-OHDA-lesioned rat PD model demonstrating that inhibition of GPR6 activity in vivo normalizes activity in basal ganglia circuitry and motor behavior. CVN424 is currently in clin. development to treat motor symptoms in Parkinson’s disease.

Journal of Medicinal Chemistry published new progress about Basal ganglia (circuitry). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Clark, Terence published the artcileThe photolysis of quinomethionate in benzene solution, Formula: C9H6Cl2N2, the main research area is photolysis quinomethionate fungicide mechanism; quinoxaline.

Photolysis of the fungicide quinomethionate (I) (C6H6, for 8 h) resulted in cleavage of the dithiole ring with loss of both S atoms to give quinoxaline dione II and the methylquinoxalines III (R ≠ R1 = H, Me). A mechanism is proposed involving initial loss of CO followed by rapid loss of S, either as the element or after oxidation

Pesticide Science published new progress about Cyclocondensation reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

El-Sharief, A. M. SH. published the artcileNovel synthesis and cyclization reactions of 3-amino-2-mercaptopyrrole derivatives, SDS of cas: 39267-05-5, the main research area is pyrrolopyrrolinedione preparation; pyrrolothiazole preparation; pyrrolothiazine preparation; pyrrole aminomercapto preparation cyclization; cyanothioformamide chalcone cyclization; aminomercaptopyrrole preparation cyclization chloroacetate chloroacetamide chloronaphthoquinone; isocyanate cyclization aminomercaptopyrrole; chlorobenzoyl chloride cyclization aminomercaptopyrrole.

Interaction of cyanothioformamides RNHC(:S)CN (R = Me, Et, Ph) with chalcones gave 3-amino-2-mercaptopyrroles I (R1, R2 = H, Cl, Br), which have the tautomeric structures of 3-aminopyrroline-2-thiones and 3-iminopyrrolidine-2-thiones. I reacted with chloroacetic acid, Et chloroacetate, chloroacetamide and 2,3-dichloro-1,4-naphthoquinone to give pyrrolothiazines. Reaction of I with PhN:C:O or p-ClC6H4COCl gave pyrrolothiazoles. Reaction of maleimides with RNHC(:S)CN gave pyrrolopyrrolinediones.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Cyclocondensation reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, SDS of cas: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Borjigin, Naraso published the artcilen- and p-Channel field-effect transistors based on diquinoxalino TTF derivatives, SDS of cas: 39267-05-5, the main research area is diquinoxalino TTF derivative field effect transistor structure optical property.

Three new quinoxalinoTTF derivatives with Me, trifluoromethyl and fluoro groups were synthesized and characterized by UV-visible absorption spectroscopy, DSC, x-ray single crystal anal., x-ray diffraction, and field-effect transistor (FET) characteristics. All of them have π-stacking structures in the single crystals. The quinoxalinoTTF derivative with trifluoromethyl groups exhibited an n-type FET, which is a rare example of n-channel FETs based on TTF derivatives The highest electron mobility is 0.01 cm2 V-1 s. The FET polarity was converted to p-channel from n-channel by replacing the trifluoromethyl groups with Me groups. The hole mobility is ≤0.2 cm2 V-1 s. In contrast, the fluoro substituted derivative did not show FET properties due to the poorly ordered mol. arrangement.

Synthetic Metals published new progress about Differential scanning calorimetry. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, SDS of cas: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nakhi, Ali published the artcilePyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay, Name: 2,3-Dichloro-6-methylquinoxaline, the main research area is luciferase reporter gene assay false pos result; pyrroloquinoxaline preparation inhibitor firefly luciferase.

2-Substituted pyrrolo[2,3-b]quinoxalines having free NH were prepared directly from 3-alkynyl-2-chloroquinoxalines in a single pot by using readily available and inexpensive methanesulfonamide (or p-toluenesulfonamide) as an ammonia surrogate. The reaction proceeded in the presence of Cu(OAc)2 affording the desired product in moderate yield. The crystal structure anal. of a representative compound and its supramol. interactions are presented. Some of the compounds synthesized exhibited inhibitory activities against luciferase that was supported by the predictive binding mode of these compounds with luciferase enzyme through mol. docking studies. The key observations disclosed here can alert users of luciferase reporter gene assays for possible false pos. results due to the direct inhibition of luciferase.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Name: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider