Category: 39267-05-5

Kumar, Sonu published the artcileRegioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines, Computed Properties of 39267-05-5, the main research area is aryl alkynyl quinoxaline regioselective iodocyclization; iodobenzophenazine preparation.

A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallog. studies of the compound

Organic & Biomolecular Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Computed Properties of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Mohan Saini, Kapil published the artcileTrifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines, Category: quinoxaline, the main research area is furoquinoxaline preparation; dichloroquinoxaline alkyne cyclization copper palladium catalyst; furopyrazine preparation; pyrazine alkyne cyclization copper palladium catalyst.

A trifluoroacetic acid promoted step-economical one-pot approach to the synthesis of furo-fused quinoxalines/ I (R = C6H5, 4-CF3C6H4, thiophen-3-yl, etc.; R1, R2 = H, Me, Cl)/pyrazines II (R3 = 2-Me, 4-Et, 4-nBu, etc.) by the reaction of 2,3-dichloroquinoxalines such as 2,3-dichloroquinoxaline, 2,3-dichloro-6-methylquinoxaline, 2,3-dichloro-6,7-dimethylquinoxaline, 2,3,6,7-tetrachloroquinoxaline /2,3-dichloropyrazine with alkynes RCCH is described. The reaction involves a selective in-situ Sonogashira coupling step and a hydroxylation followed by a metal-free 5-endo-dig cyclization. Preliminary experiments show that trifluoroacetic acid acts as a source of oxygen for the oxyarylation step, and isotopic labeling studies support the proposal that the mechanistic pathway involves activation of the alkyne by the acidic medium. Various kinds of substituents are tolerated, which should prove valuable for structural and biol. investigations.

European Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Category: quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Pei-Ming published the artcileA One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst, SDS of cas: 39267-05-5, the main research area is dichloroquinoxaline preparation green chem; aromatic diamine oxalic acid tandem heterocyclization silica gel catalyst.

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives I (R1 = H, H3CO, Cl, etc.; R2 = H, F, CH3, etc.; R3 = H, CH3; R1R2 = CH=CH-CH=CH). The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamines 2-H2N-3-R3-4-R1-5-R2C6HNH2 and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines I have been obtained in good to excellent overall yields.

Journal of Heterocyclic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, SDS of cas: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ko, Kwangseok published the artcileDiscovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis, Formula: C9H6Cl2N2, the main research area is atopic dermatitis H4 receptor antagonist preparation; pyrido tetrazolo pyrazine analog preparation atopic dermatitis.

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been developed yet. Here, we have discovered a novel class of orally available H4R antagonists showing strong anti-itching and anti-inflammation activity as well as excellent selectivity against off-targets. A pharmacophore-based virtual screening system constructed in house successfully identified initial hit compound 9, and the subsequent homol. model-guided optimization efficiently led us to discover pyrido[2,3-e]tetrazolo[1,5-a]pyrazine analog 48 as a novel chemotype of a potent and highly selective H4R antagonist. Importantly, orally administered compound 48 exhibits remarkable efficacy on antipruritus and anti-inflammation with a favorable pharmacokinetic (PK) profile in several mouse models of AD. Thus, these data strongly suggest that our compound 48 is a promising clin. candidate for treatment of AD.

Journal of Medicinal Chemistry published new progress about 5-HT receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gan, Linling published the artcileTetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Partial Agonists: Design, Synthesis, Structure-Activity Relationship, and Anticancer Activities, HPLC of Formula: 39267-05-5, the main research area is tetrazanbigen derivative peroxisome proliferator activated receptor gamma partial agonist; anticancer tetrazanbigen derivative.

Tetrazanbigen (TNBG) is a novel sterol isoquinoline derivative with poor water solubility and moderate inhibitory effects on human cancer cell lines via lipoapoptosis induction. Herein, we developed a series of novel TNBG analogs with improved water solubility and antiproliferative activities. The CCK-8 assay enabled us to identify a novel compound, 14g, which strongly inhibited HepG2 and A549 cell growth with IC50 values of 0.54 and 0.47μM, resp. The anticancer effects might be explained by the partial activation and upregulation of PPARγ expression, as indicated by the transactivation assay and western blotting evaluation. Furthermore, the in vitro antiproliferative activity was verified in an in vivo xenograft model in which 14g strongly reduced tumor growth at a dose of 10 mg/kg. In line with these pos. observations, 14g exhibited an excellent water solubility of 31.4 mg/mL, which was more than 1000-fold higher than that of TNBG (4μg/mL). Together, these results suggest that 14g is a promising anticancer therapeutic that deserves further investigation.

Journal of Medicinal Chemistry published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (PTEN). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kumar, Sonu published the artcilePalladium-Catalyzed Intramolecular Fujiwara-Hydroarylation: Synthesis of Benzo[a]phenazines Derivatives, COA of Formula: C9H6Cl2N2, the main research area is benzophenazine preparation palladium catalyzed intramol Fujiwara hydroarylation; hydroarylation ethynylquinoxaline benzophenazine preparation deuterium labeling.

An atom-economical Pd-catalyzed approach for the synthesis of benzophenazine derivatives using substituted 2-aryl-3-(aryl/alkylethynyl) quinoxaline in the presence of trifluoroacetic acid at 65 °C has been described. The chem. involves in situ generation of cationic Pd(II) species, which functionalized the aromatic C-H bonds via electrophilic metalation followed by concomitant intramol. trans-insertion of C-C triple bond to aryl-Pd complex. The results were supported by various control experiments including with electron-deficient arenes and deuterium labeling studies. The deuterium labeling studies supports electrophilic palladation of aromatic C-H over activation of C-C triple bond of alkyne. The structure of synthesized compounds was further confirmed by X-ray crystallog. studies. This catalytic protocol has been efficiently applied for novel synthesis of highly functionalized benzo fused phenazines.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, COA of Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bouanane, Zohra published the artcileSynthesis, structural, catecholase, tyrosinase and DFT studies of pyrazoloquinoxaline derivatives, Safety of 2,3-Dichloro-6-methylquinoxaline, the main research area is pyrazolylquinoxaline derivative preparation copper ligand catecholase activity; mol structure pyrazolylquinoxaline copper complex DFT; electronic structure pyrazolylquinoxaline copper complex DFT.

Six functional multidentate ligands: 2,3-bis(3,5-dimethyl-1H-pyrazol-1-yl) quinoxaline L1, 2,3-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-nitroquinoxaline L2, 2,3-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylquinoxaline L3, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-hydrazinyl-6-nitroquinoxaline L4, 2-chloro-3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylquinoxaline L5, 2-chloro-3-(3,5-dimethyl-1H-pyrazol-1-yl)quinoxaline L6, (I – VI) and a new copper (II) complex (VII) , were prepared and evaluated for their catecholase activities at aerobic conditions. We found that, the reaction rate depends on: the nature of the substituents in the quinoxaline ring, counter anion, metal, concentration of ligand and the used solvent. The complex obtained in-situ from reaction of one equivalent of ligand L1 and two equivalent of Cu(CH3COO)2 in methanol showed the highest oxidation rate activity (V = 33.48 μmol L-1. min-1). In addition, geometry optimizations of the complexes in order to get better insight into the geometry and the electronic structure and chem. reactivity were carried out by means of DFT calculations

Journal of Molecular Structure published new progress about Counterions (counterion effect on catecholase activity). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Safety of 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nakhi, Ali published the artcileAlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest, HPLC of Formula: 39267-05-5, the main research area is diarylvinyl arylquinoxaline preparation aluminum chloride mediated hydroarylation heteroarylation; densely functionalized olefin arylquinoxaline mol docking sirtuin protein inhibitor.

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, 2-(2,2-diarylvinyl)-3-arylquinoxalines, such as I, as potential inhibitors of sirtuins.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Inoue, Mami published the artcileInherently Chiral Cavitand Curvature: Diastereoselective Oxidation of Tethered Allylsilanes, Formula: C9H6Cl2N2, the main research area is chiral cavitand tethered allylsilane preparation stereoselective oxidation; epoxide chiral cavitand tethered silane preparation.

Syntheses of inwardly and outwardly directed allylsilanes those are tethered to new inherently chiral cavitands are described. Oxidized with mCPBA, these allylsilanes result in diastereomeric mixtures of epoxide mols. Thus, it enables the authors to have comparative study of cavitand-structure diastereoselectivity relation, which revealed that an inward allylsilane group flanked by a dibenzo[f, h]quinoxaline and two bridged methylene groups have the best chem. yield and diastereoselection.

European Journal of Organic Chemistry published new progress about Epoxidation, stereoselective. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider