Category: 40353-41-1

Lian, Mi published the artcileLogic design and synthesis of quinoxalines via the integration of iodination/oxidation/cyclization sequences from ketones and 1,2-diamines, SDS of cas: 40353-41-1, the main research area is quinoxaline preparation; iodination oxidation cyclization aryl ketone diamine; phenylene diamine iodination oxidation cyclization aryl ketone.

A novel protocol for the synthesis of quinoxalines has been developed from simple ketones and 1,2-diamines. This process underwent a logic approach to bis-substituted quinoxalines via a consecutive iodination/Kornblum oxidation/cyclization in the presence of I2/CuO/DMSO and to mono-substituted quinoxalines via an iodination/cyclization/aromatization in the presence of I2/CuO/K3PO4·3H2O.

Tetrahedron published new progress about Aromatization. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, SDS of cas: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Harsha, Kachigere B. published the artcileAn Easy and Efficient Method for the Synthesis of Quinoxalines Using Recyclable and Heterogeneous Nanomagnetic-Supported Acid Catalyst under Solvent-Free Condition, Computed Properties of 40353-41-1, the main research area is quinoxaline preparation solvent free green chem anticancer human; diketone ortho phenylenediamine cyclocondensation nanocatalyst.

Synthesis of quinoxalines from o-phenylenediamines (o-PDs) with electronically diversified 1,2-diketones and α-bromoketones via simple cyclocondensation reaction using an heterogeneous nano-gamma-Fe2O3-SO3H catalyst has been reported under solvent free condition. Low cost, easy workup, high yield, operational simplicity, less reaction time, environmentally benign nature and catalyst is magnetically retrievable and can be reused up to five catalytic cycles without significant loss in the product yields are the noteworthy features of this protocol.

ChemistrySelect published new progress about Antitumor agents. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Computed Properties of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Harsha, Kachigere B. published the artcileOne-step approach for the synthesis of functionalized quinoxalines mediated by T3P-DMSO or T3P via a tandem oxidation-condensation or condensation reaction, Related Products of quinoxaline, the main research area is phenyldiamine hydroxyketone propylphosphonic anhydride tandem oxidation condensation quinoxaline preparation; bromoketone phenyldiamine propylphosphonic anhydride tandem oxidation condensation quinoxaline preparation; diketone phenyldiamine propylphosphonic anhydride condensation quinoxaline preparation; quinoxaline preparation structure activity relationship antitumor activity.

An easy and efficient propylphosphonic anhydride (T3P)-DMSO or T3P mediated oxidation-condensation or condensation reaction for the synthesis of quinoxalines derived from the interaction of different arrays of condensing partners with ortho-phenylene diamines (o-PDs) under simple and mild reaction conditions in one step were reported for the first time.

RSC Advances published new progress about Antitumor agents. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Li, Xiaoqing published the artcileAn iodobenzene-catalysed domino route toward quinoxaline derivatives from simple ketones and o-phenylenediamines in one pot, SDS of cas: 40353-41-1, the main research area is quinoxaline derivative preparation iodobenzene catalyst.

An iodobenzene-catalyzed domino route to quinoxalines from ketones and o-phenylenediamines in one pot was developed. This transformation consisted of the generation of Koser’s generation, α-tosyloxylation of ketones, nucleophilic substitution and intramol. dehydration with o-phenylenediamines, and dehydrogenation.

Journal of Chemical Research published new progress about Dehydration reaction. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, SDS of cas: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

McKinney, Andrew M. published the artcileA rapid and efficient method for the reduction of quinoxalines, Application In Synthesis of 40353-41-1, the main research area is quinoxaline borane stereoselective reduction; hydroquinoxaline preparation.

Mono- and di-substituted alkyl- and arylquinoxalines are rapidly reduced in high yield to their resp. 1,2,3,4-tetrahydro derivatives by BH3 in THF solution In the case of the 2,3-di-substituted compounds, reduction is stereoselective yielding exclusively the cis-isomers. NaBH4 in AcOH also reduces alkyl- and arylquinoxalines, but proceeds with lower yields and often produces side products. NaBH4 in EtOH reduces quinoxaline and 2-methylquinoxaline in high yield. However, the reaction is very slow, whereas 2,3-dialkyl- and 2-arylquinoxalines are not efficiently reduced by NaBH4 in EtOH.

Journal of Heterocyclic Chemistry published new progress about Reduction, stereoselective. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Application In Synthesis of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Shi, Ren-xin published the artcileSodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives, Safety of 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline benzodiazepine preparation sodium tetrachloroaurate; furan thiophene phenyl quinoxaline preparation.

Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocyclic components in pharmaceutical compounds The synthesis of the target compounds was achieved efficiently and cleanly using benzenediamine and ketones as reactants and sodium tetrachloroaurate(III) dihydrate as catalyst. This catalyst was shown to be effective for the synthesis of quinoxaline derivatives from phenylenediamine and α-bromo ketones under similar reaction conditions.

Journal of Zhejiang University, Science, B published new progress about Cyclocondensation reaction. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Safety of 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Peng, Yun published the artcileReactivity Umpolung of the C=N Bond in Quinoxaline Scaffold Enabling Direct Nucleophilic Attack of Alkyl Grignard Reagents at the N-Terminus, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline Grignard reagent tandem regioselective alkylation carbon bond cleavage; quinoxalinone preparation.

The reactivity umpolung of the C=N bond in the quinoxaline scaffold was successfully realized for the first time by introduction of a formyl or an acyl group adjacent to the C-position of the C=N moiety. The reversed reactivity of the C=N bond thus enabled direct nucleophilic attack of alkyl Grignard reagents at the N-terminus rather than the C-terminus, thereby providing an unprecedented and efficient method for the synthesis of quinoxalin-2(1H)-one derivatives involving a tandem N-alkylation/C-C bond cleavage process.

Organic Letters published new progress about Alkylation, regioselective. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lou, Shao-Jie published the artcilePd(OAc)2-catalyzed regioselective aromatic C-H bond fluorination, Name: 2-(Thiophen-2-yl)quinoxaline, the main research area is palladium acetate catalyzed regioselective aromatic carbon hydrogen bond fluorination.

A novel Pd(OAc)2-NFSI-TFA system was developed for the highly selective ortho-monofluorination directed by diverse aryl-N-heterocyclic directing groups e.g., quinoxaline, pyrazole, benzo[d]oxazole, and pyrazine derivatives A Pd(ii/iv) catalytic cycle was proposed based on the ESI-MS/MS studies.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-H bond activation (aromatic). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Name: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Satish, Gandhesiri published the artcileI2Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: application to synthesis of pyrazine, β-carboline and quinoxalines, Category: quinoxaline, the main research area is enedione preparation stereoselective; ketoester domino reaction iodine copper acetate catalyst; quinoxaline carboline pyrazine preparation; diamine aryl enedione preparation nucleophilic addition iodine catalyst.

A self-sorting domino reaction of aryl β-ketoesters RC6H4C(O)CH2C(O)OCH2CH3 into sym. E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R was reported by an I2/Cu system. The reaction proceeds through tandem iodination, self-dimerization and Krapcho dealkoxycarbonylation in one pot under open air condition. Further, E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R were successfully employed for the synthesis of bioactive pyrazine, β-carboline and quinoxalines I via aza-Michael addition, intramol. cyclization and C-C bond cleavage of 1,3-dicarbonyl unit under mild reaction condition.

RSC Advances published new progress about Diastereoselective synthesis. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Category: quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ucar, Sefa published the artcileTransition Metal-Free Heteroarylation of Quinoxaline: Construction of Heteroaryl-Fused Phenazines by Oxidative Coupling, Formula: C12H8N2S, the main research area is heteroarylquinoxaline preparation quinoxaline heteroarylation transition metal free fluorescence; phenazine heteroaryl fused preparation diheteroarylquinoxaline oxidative coupling fluorescence.

A concise method for the construction of heteroaryl-fused phenazines was developed via PIFA-BF3·Et2O-mediated oxidative coupling of di-heteroarylated quinoxalines for the first time. Synthesis of mono- and di-heteroarylation of quinoxaline was performed effectively using only LiTMP reagent under transition metal-free conditions and without the use of halogen-containing starting compounds In addition, nonsym. di-heteroarylated quinoxalines were synthesized through reheteroarylation of mono-heteroarylated quinoxalines in the same way. Oxidation of the saturated compounds formed after heteroarylation was easily accomplished with iodine. The UV-vis absorption and fluorescence features of some compounds were examined

Journal of Organic Chemistry published new progress about Diastereoselective synthesis. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Formula: C12H8N2S.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider