Category: 40353-41-1

Matsumura, Mio published the artcileSynthesis of 2-arylquinoxalines: triarylstibane-catalyzed oxidative cyclization of α-hydroxy ketones with 1,2-diamines under aerobic conditions, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline aryl preparation; diamine hydroxy ketone aerobic oxidative cyclization triarylstibane catalyst.

The reaction of α-hydroxy ketones ArC(O)CH2OH (Ar = Ph, 4-bromophenyl, 2-naphthyl, 2-thienyl, etc.) with 1,2-diamines such as benzene-1,2-diamine, 4,5-dibromobenzene-1,2-diamine, naphthalene-2,3-diamine, etc. in the presence of triphenylstibane (10 mol%) as catalyst led to the formation of 2-arylquinoxalines I (R1 = H, MeO, Me, Br, CN, CF3; R2 = H, MeO, Br, Me, CN; R1R2 = CH=CH-CH=CH) in moderate to good yield under aerobic conditions. This reaction is the first example of oxidative cyclization catalyzed by organoantimony compounds

Heterocycles published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Guntreddi, Tirumaleswararao published the artcileElemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids, Quality Control of 40353-41-1, the main research area is aminophenol cinnamic acid decarboxylative coupling reaction; arylmethyl benzoxazole preparation; mercaptoaniline cinnamic acid decarboxylative coupling reaction; benzothiazole arylmethyl preparation; aminoaniline cinnamic acid decarboxylative coupling reaction; aryl quinoxaline preparation.

An easy and practical method was developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines resp. under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids led to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation was versatile and compatible with a number of functional groups.

RSC Advances published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Quality Control of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Xu, Yingying published the artcileIridium-Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β-Keto Thioethers in Water, Formula: C12H8N2S, the main research area is keto thioether green preparation carbenoid insertion annulation water; quinoxaline green preparation carbenoid insertion annulation water.

Sulfoxonium ylides as safe carbene precursors are described for iridium-catalyzed carbene insertions and annulation, providing a facile and green approach to access a variety of quinoxaline derivatives in water. This water-mediated method also allows the preparation of β-keto thioethers under mild condition.

European Journal of Organic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent) (ortho). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Formula: C12H8N2S.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Emmadi, Narender Reddy published the artcileSodium dodecylsulfate induced synthesis of quinoxalines, Related Products of quinoxaline, the main research area is quinoxaline preparation; phenylenediamine bromo ketone sodium dodecyl sulfate heterocyclization green chem.

A simple and efficient sodium dodecylsulfate (SDS) induced method for the synthesis of quinoxalines in excellent yields in water at room temperature by the reaction of phenacyl bromides and o-phenylene diamines was developed. Simple reaction conditions, wide compatibility and high yields were the advantages of this protocol.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent) (bromo). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Liu, Yun-Kui published the artcileRegiospecific Synthesis of Nitroarenes by Palladium-Catalyzed Nitrogen-Donor-Directed Aromatic C-H Nitration, Category: quinoxaline, the main research area is nitro arene regioselective preparation palladium catalyst; regioselective nitration arene nitrogen functional group guided.

Regioselective approach to nitroarenes involving palladium-catalyzed direct ortho-nitration of aromatic C-H bonds guided by a nitrogen functional group is described. E.g., Pd-catalyzed ortho-nitration of aromatic C-H bonds directed by a quinoxaline ligand (e.g., I) in presence of Pd(OAc)2, AgNO2, and K2S2O8 as oxidant gave 86% nitroarene II. The nitrating protocol was applied to other N-donor tethered aromatics [e.g., 2-arylpyridines, benzo[h]quinoline, 2-arylpyrazoles].

Chemistry – A European Journal published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Category: quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Crundwell, Guy published the artcileBis[2-(thiophen-2-yl)quinoxaline-κN 4]silver(I) tetrafluoridoborate, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is crystal structure coordination compound silver bisthienylquinoxaline complex tetrafluoridoborate; mol structure silver bisthienylquinoxaline complex tetrafluoridoborate.

In the title compound, [Ag(C12H8N2S)2]BF4, the two-coordinate AgI ion lies on a crystallog. inversion center and is linearly bonded to the N-donor atoms of two sep. quinoxaline ligands. The thienyl ring of the ligand is nearly coplanar with the quinoxaline ring system [dihedral angle = 9.15 (13)°]. In the crystal, the complex mols. pack in layers parallel to (-102) and form weak π-π ring stacking interactions [min. ring centroid separation = 3.7054 (17) Å]. The tetrafluoridoroborate anion is equally disordered about an inversion center. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Dubovtsev, Alexey Yu. published the artcileNature of the Nucleophilic Oxygenation Reagent Is Key to Acid-Free Gold-Catalyzed Conversion of Terminal and Internal Alkynes to 1,2-Dicarbonyls, SDS of cas: 40353-41-1, the main research area is alkyne gold catalyst dichloropyridine nitrogen oxide nucleophilic oxygenation; diketone preparation; azaheterocycle one pot preparation.

2,3-Dichloropyridine N-oxide, a novel oxygen transfer reagent, allows the conductance of the gold(I)-catalyzed oxidation of alkynes to 1,2-dicarbonyls in the absence of any acid additives and under mild conditions to furnish the target species, including those derivatized by highly acid-sensitive groups. The developed strategy is effective for a wide range of alkyne substrates such as terminal- and internal alkynes, ynamides, alkynyl ethers/thioethers, and even unsubstituted acetylene (40 examples; yields up to 99%). The oxidation was successfully integrated into the trapping of reactive dicarbonyls by one-pot heterocyclization and into the synthesis of six-membered azaheterocycles. This synthetic acid-free route was also successfully applied for the total synthesis of a natural 1,2-diketone.

Journal of Organic Chemistry published new progress about Catalyst supports, oxidation catalyst supports. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, SDS of cas: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gazit, Aviv published the artcileTyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins, Related Products of quinoxaline, the main research area is quinoxaline tyrosine kinase inhibitor preparation structure; platelet growth factor receptor kinase preparation; quinoline tyrosine kinase inhibitor preparation structure; indole tyrphostin tyrosine kinase inhibitor preparation; MSBAR tyrosine kinase inhibitor tyrphostin.

A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The potency of the inhibitors was quinoxalines >quinolines >indoles. Lipophilic groups (Me, methoxy) in the 6 and 7 positions and Ph at the 3 position of quinoxalines and quinolines were essential for potency, in contrast to the hydrophilic catechol group in tyrphostins active against EGFR kinase inhibition at different sites. The inhibitors showed selectivity for PDGF and were not active against EGF receptor and HER-2/c-ErbB-2 receptor.

Journal of Medicinal Chemistry published new progress about. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Liu, Yunkui published the artcileMultifold Bond Cleavage and Formation between MeOH and Quinoxalines (or Benzothiazoles): Synthesis of Carbaldehyde Dimethyl Acetals, Product Details of C12H8N2S, the main research area is quinoxaline methanol potassium persulfate cross coupling; quinoxalinyl carbaldehyde dimethyl acetal preparation green chem; benzothiazole methanol potassium persulfate cross coupling; benzothiazolyl carbaldehyde dimethyl acetal preparation green chem.

A K2S2O8-mediated direct cross-coupling of quinoxalines (or benzothiazoles) with methanol leading to 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde di-Me acetals has been achieved. 2-Quinoxalinyl carbaldehyde di-Me acetals were readily converted into 2-quinoxalinyl carbaldehydes in good to excellent yields under acidic conditions. Preliminary mechanistic studies suggest that the reaction proceeds via multifold bond cleavage and formation between methanol and N-heterocycles involving a dioxygen-participated radical process. This method allows for the synthesis of a variety of 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde di-Me acetals directly via cross-coupling of simple N-heterocyclic C-H bond and methanol under aldehyde-, acid-, and transition-metal-free conditions.

Journal of Organic Chemistry published new progress about Aryl aldehydes, heteroaryl Role: SPN (Synthetic Preparation), PREP (Preparation) (quinoxalinyl). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Product Details of C12H8N2S.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sahoo, Subas Chandra published the artcileDirect Aerobic Oxidative Reactions of 2-Hydroxyacetophenones, Quality Control of 40353-41-1, the main research area is phthalide preparation; isochromandione hydroxyacetophenone aerobic oxidation; quinoxaline preparation; diamine aryl hydroxyacetophenone aerobic oxidation; amide keto preparation; pyrrolidine hydroxyacetophenone aerobic oxidation.

Valuable and direct aerobic oxidation reactions of 2-hydroxyacetophenones R1C(O)CH2OH (R1 = thien-2-yl, 2H-1,3-benzodioxol-5-yl, 2-O2NC6H4, etc.) were explored. The concept was based on the in situ treatment of small quantities of aerobically formed α-keto aldehydes that drove the reactions to the corresponding products. This new strategy was applied for a variety of oxidative reactions of 2-hydroxyacetophenones, and valuable products such as phthalides I (R2 = H, 7-CH3O), quinoxalines II (R3 = H, 6,7-Cl2, 6-NO2) and α-keto amides R1(C(O))2X (X = pyrrolidin-1-yl) were obtained in good to high yields.

European Journal of Organic Chemistry published new progress about Amides, oxo Role: SPN (Synthetic Preparation), PREP (Preparation). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Quality Control of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider