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The synthesis of new 2-fluoro-, 3-fluoro- and 2,3-difluoroquinoxalines by nucleophilic substitution with cesium fluoride as coupled with 18-crown-6 and their herbicidal activities are described.

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The present invention relates to isothiazoles of general formula (I) which inhibit the mitotic checkpoint : in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

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New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. Recommanded Product: 2-Chloro-6-(trifluoromethyl)quinoxaline, We’ll be discussing some of the latest developments in chemical about CAS: 41213-32-5, name is 2-Chloro-6-(trifluoromethyl)quinoxaline. In an article,Which mentioned a new discovery about 41213-32-5

The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, R5, R6, Y1 and Y2 have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as acaricides and/or insecticides for controlling animal pests. The compounds of the formula (I) are also suitable as nematicides for plant-damaging pests and/or anthelminthics for endoparasites in humans and animals.

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The fused heterocyclic compound represented by formula (1) has excellent effectiveness in pest control. (In the formula, J represents formula J1, J2, J3, J4, J5 or J6; A1 represents a nitrogen atom, etc.; A2 represents a nitrogen atom, etc.; A3 represents a nitrogen atom, etc.; A4 represents a nitrogen atom, etc.; A5 represents a nitrogen atom, etc.; B1 represents a nitrogen atom, etc.; B2 represents a nitrogen atom, etc.; B3 represents NR15, etc.; B4 represents a nitrogen atom, etc.; B5 represents a nitrogen atom, etc.; B6 represents a nitrogen atom, etc.; R1 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R2 and R3 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R4 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group W; R5 and R6 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; and n represents 0, 1,2).

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A cyanoketone derivative of the following formula (1) STR1 wherein A1 is a substituted or unsubstituted phenyl or naphthyl group or a substituted or unsubstituted heterocyclic group; each of X1, X2 and X3 is independently an oxygen or sulfur atom; each of B1, B2 and B3 is independently a hydrogen atom or C1 -C6 -alkyl group; each of Y1, Y2, Y3 and Y4 is independently a hydrogen atom, a halogen atom or a C1 -C6 -alkyl group; and A2 is a substituted or unsubstituted group selected from the group consisting of a C1 -C6 -alkyl group, a C2 -C6 -alkenyl group, a C2 -C6 -alkynyl group, a C1 -C4 -alkoxy group, a C1 -C4 -alkylthio group, a C1 -C6 -alkoxycarbonyl group, an unsubstituted benzoyl group, a halogen-substituted benzoyl group, a cyano group or a group as defined in A1 ; provided that when B1 is a hydrogen atom and B2 is alkyl, the compound of the formula (1) is an R- or S-enantiomer with regard to asymmetric carbon to which B1 and B2 are bonded, or a mixture of these enantiomers. The cyanoketone derivative has a remarkably high herbicidal activity and is effective against a variety of gramineous weeds.

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The present invention relates to compounds of formulawherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.

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COA of Formula: C9H4ClF3N2, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 41213-32-5, Name is 2-Chloro-6-(trifluoromethyl)quinoxaline, molecular formula is C9H4ClF3N2. In a article,once mentioned of 41213-32-5

Thirty-five quinoxalines bearing a substituted amiline group on position 2 and various substituents on positions 3, 6, 7 and 8 were prepared in order to evaluate in vitro anticancer activity. Structural elucidation of some isomeric quinoxalinones formed by ring closure of 4-substituted-1,2-diaminobenzenes with dicarbonyl compounds was achieved by comparison with one isomer coming from an unambiguous independent route. Preliminary in vitro screening at NCI showed that many compounds exhibited a moderate to strong growth inhibition activity on various cell lines between 10-5 and 10-4 molar concentrations.

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Synthetic Route of 41213-32-5, New research progress on 41213-32-5 in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 41213-32-5, Name is 2-Chloro-6-(trifluoromethyl)quinoxaline, molecular formula is C9H4ClF3N2. In a Article,once mentioned of 41213-32-5

Novel 5-methyltetrazolo<1,5-a>quinoxalin-4-ones (5) and 5-methyl-1,2,4-triazolo<4,3-a>quinoxalin-4-ones (7) could be synthesized from 1-methyl-3-chloroquinoxalin-2-ones (3) and 1-methyl-3-hydrazinoquinoxalin-2-ones (6), respectively.Further extensive study was carried out to synthesize 4- or 7- substituted and 4,7-disubstituted tetrazolo<1,5-a>quinoxalines (10) and 1,2,4-triazolo<4,3-a>quinoxalines (12).

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Facile synthesis of quinoxalinyl-2-oxyphenols are described.The condensation of 2-chloroquinoxalines with three molar equivalent of dihydroxybenzene in basic medium gave preferentially quinoxalinyl-2-oxyphenols, which involves nucleophilic cleavage of the initially formed bis(quinoxalinyl-2-oxy)benzenes by an excess of dihydroxybenzene.

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The first syntheses of 4-chloro-2-(2-quinoxalinyl)-pyridazin-3(2H)-one derivatives are reported.They could be synthesized from 2-hydrazinoquinoxaline derivatives as starting materials.

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