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A cyanoketone derivative of the following formula (1) STR1 wherein A1 is a substituted or unsubstituted phenyl or naphthyl group or a substituted or unsubstituted heterocyclic group; each of X1, X2 and X3 is independently an oxygen or sulfur atom; each of B1, B2 and B3 is independently a hydrogen atom or C1 -C6 -alkyl group; each of Y1, Y2, Y3 and Y4 is independently a hydrogen atom, a halogen atom or a C1 -C6 -alkyl group; and A2 is a substituted or unsubstituted group selected from the group consisting of a C1 -C6 -alkyl group, a C2 -C6 -alkenyl group, a C2 -C6 -alkynyl group, a C1 -C4 -alkoxy group, a C1 -C4 -alkylthio group, a C1 -C6 -alkoxycarbonyl group, an unsubstituted benzoyl group, a halogen-substituted benzoyl group, a cyano group or a group as defined in A1 ; provided that when B1 is a hydrogen atom and B2 is alkyl, the compound of the formula (1) is an R- or S-enantiomer with regard to asymmetric carbon to which B1 and B2 are bonded, or a mixture of these enantiomers. The cyanoketone derivative has a remarkably high herbicidal activity and is effective against a variety of gramineous weeds.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1857 | ChemSpider

 

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Novel 5-methyltetrazolo<1,5-a>quinoxalin-4-ones (5) and 5-methyl-1,2,4-triazolo<4,3-a>quinoxalin-4-ones (7) could be synthesized from 1-methyl-3-chloroquinoxalin-2-ones (3) and 1-methyl-3-hydrazinoquinoxalin-2-ones (6), respectively.Further extensive study was carried out to synthesize 4- or 7- substituted and 4,7-disubstituted tetrazolo<1,5-a>quinoxalines (10) and 1,2,4-triazolo<4,3-a>quinoxalines (12).

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Reference:
Quinoxaline – Wikipedia,
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Thirty-three quinoxalines bearing an aminobenxoyl or aminobenzoylglutammate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31.37) the antifungal activity was prevailing.

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SUBSTITUTED QUINOXALINE DERIVATIVES AS PEST CONTROL AGENT

The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, R5, R6, Y1 and Y2 have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as acaricides and/or insecticides for controlling animal pests. The compounds of the formula (I) are also suitable as nematicides for plant-damaging pests and/or anthelminthics for endoparasites in humans and animals.

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Reference:
Quinoxaline – Wikipedia,
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AMINO-SUBSTITUTED ISOTHIAZOLES

The present invention relates to isothiazoles of general formula (I) which inhibit the mitotic checkpoint : in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

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Quinoxaline – Wikipedia,
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FUSED HETEROCYCLIC COMPOUND

The fused heterocyclic compound represented by formula (1) has excellent effectiveness in pest control. (In the formula, J represents formula J1, J2, J3, J4, J5 or J6; A1 represents a nitrogen atom, etc.; A2 represents a nitrogen atom, etc.; A3 represents a nitrogen atom, etc.; A4 represents a nitrogen atom, etc.; A5 represents a nitrogen atom, etc.; B1 represents a nitrogen atom, etc.; B2 represents a nitrogen atom, etc.; B3 represents NR15, etc.; B4 represents a nitrogen atom, etc.; B5 represents a nitrogen atom, etc.; B6 represents a nitrogen atom, etc.; R1 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R2 and R3 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R4 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group W; R5 and R6 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; and n represents 0, 1,2).

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Quinoxaline – Wikipedia,
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FACILE SYNTHESIS AND HERBICIDAL ACTIVITIES OF NOVEL FLUOROQUINOXALINES

The synthesis of new 2-fluoro-, 3-fluoro- and 2,3-difluoroquinoxalines by nucleophilic substitution with cesium fluoride as coupled with 18-crown-6 and their herbicidal activities are described.

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THE SYNTHESES OF NOVEL 2-(2-QUINOXALINYL)PYRIDAZIN-3(2H)-ONES

The first syntheses of 4-chloro-2-(2-quinoxalinyl)-pyridazin-3(2H)-one derivatives are reported.They could be synthesized from 2-hydrazinoquinoxaline derivatives as starting materials.

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Quinoxaline chemistry. Part 4. 2-(R)-anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity

Thirty-five quinoxalines bearing a substituted amiline group on position 2 and various substituents on positions 3, 6, 7 and 8 were prepared in order to evaluate in vitro anticancer activity. Structural elucidation of some isomeric quinoxalinones formed by ring closure of 4-substituted-1,2-diaminobenzenes with dicarbonyl compounds was achieved by comparison with one isomer coming from an unambiguous independent route. Preliminary in vitro screening at NCI showed that many compounds exhibited a moderate to strong growth inhibition activity on various cell lines between 10-5 and 10-4 molar concentrations.

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THE FACILE SYNTHESIS OF QUINOXALINYL-2-OXYPHENOLS

Facile synthesis of quinoxalinyl-2-oxyphenols are described.The condensation of 2-chloroquinoxalines with three molar equivalent of dihydroxybenzene in basic medium gave preferentially quinoxalinyl-2-oxyphenols, which involves nucleophilic cleavage of the initially formed bis(quinoxalinyl-2-oxy)benzenes by an excess of dihydroxybenzene.

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