Category: 49679-45-0

Synthesis of condensed quinoxalines. VI. Synthesis of 1H-pyrazolo[3,4-b]quinoxaline N-oxides and related compounds was written by Yoshida, Kei;Otomasu, Hirotaka. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Synthetic Route of C11H9ClN2O2 This article mentions the following:

Oxidation of 1H-pyrazolo[3.4-b]quinoxalines I (R = H, Me; n = 0) with m-chloroperbenzoic acid (MCPBA) gave the 4-oxides I (n = 1). The structures of I (n = 1) were confirmed by synthesis, by condensing 2-chloroquinoxaline-3-carboxaldehyde 4-oxide with appropriate hydrazines. Further oxidation of I (R = Me, n = 1) with MCPBA gave the 4,9-dioxide. Treatment of 1,2-dihydro-2-oxoquinoxaoline-3-carboxamide and 1,2-dihydro-2-oxoquinoxaline-3-carbonitrile 4-oxide with a mixture of POCl₃ and PCl₅ or POCl₃-DMF afforded 2-chloroquinoxaline-3-carbonitrile and its 4-oxide, resp., which reacted with hydrazines to give the corresponding 3-amino-1H-pyrazolo[3,4-b]-quinoxalines II (R¹ = H, Me) and their 4-oxides in high yields. The reaction of Et 2-chloroquinoxaline-3-carboxylate with hydrazine hydrate afforded a mixture of uncyclized products, N,N‘-bis(2-ethoxycarbonyl-3-quinoxalinyl)hydrazine, Et 2-hydrazinoquinoxaline-3-carboxylate and 2-hydrazinoquinoxaline-3-carbohydrazide. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Synthetic Route of C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Synthetic Route of C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

A theoretical study of a family of new quinoxaline derivatives was written by Pis Diez, Reinaldo;Duchowicz, Pablo R.;Castaneta, Heriberto;Castro, Eduardo A.;Fernandez, Francisco M.;Albesa, Alberto G.. And the article was included in Journal of Molecular Graphics & Modelling in 2006.SDS of cas: 49679-45-0 This article mentions the following:

Hybrid d. functional calculations are performed on a series of 21 new quinoxaline derivatives, which would likely exhibit important biol. activities. Optimized geometries, harmonic vibrational frequencies, and ¹H chem. shifts are reported and compared with exptl. data when available. In addition, m.ps. of 75 derivatives are predicted resorting to the quant. structure-property relationship (QSPR) theory, doing the variable selection by means of the replacement method and using 875 theor. descriptors obtained from Dragon 5 software. The best relationship found has seven descriptors with R = 0.8818 and R_l-10%-o = 0.7705. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0SDS of cas: 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.SDS of cas: 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis of 2-(Quinoxalin-2-ylamino-benzotriazolyl) Pentanedioic Derivatives as Potential Anti-Folate Agents was written by Briguglio, I.;Piras, S.;Corona, P.;Pirisi, M. A.;Burrai, L.;Boatto, G.;Gavini, E.;Rassu, G.. And the article was included in Journal of Heterocyclic Chemistry in 2016.Reference of 49679-45-0 This article mentions the following:

The chem. properties of quinoxalines and quinoxaline 1,4-dioxides with those of benzotriazole nucleus were combined with the aim to evaluate the resulting biol. properties. Two main new series, including more than 60 compounds, were prepared In the first one, the benzotriazole moiety was linked through the nitrogen atoms 1, 2, or 3, to a glutaric acid substituent to simulate a glutamic moiety. In the second series, the glutaric acid was substituted with acetic acid moiety to evaluate the effects of steric hindrance. Here, we described the multistep chem. processes to obtain all titled quinoxalines starting from com. available diamines. The classical oxidation of selected quinoxalines was unsuccessful and an independent synthetic pathway was explored to obtain new derivatives linked to the benzotriazole moieties starting from synthons bearing N-oxide functionality. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Reference of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Reference of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Quinoxaline chemistry. Part 8. 2-[anilino]-3-[carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity was written by Loriga, Mario;Moro, Pierangelo;Sanna, Paolo;Paglietti, Giuseppe;Zanetti, Stefania. And the article was included in Farmaco in 1997.Application of 49679-45-0 This article mentions the following:

Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10^-5 and 10^-4 molar concentrations Interesting selectivities were also recorded between 10^-8 and 10^-6 M for a few compounds One single compound exhibited good activity against Candida albicans. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-l-glutamates as analogues-homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity was written by Piras, Sandra;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 2002.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)phenylacetyl-l-glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and biological activity of heterocyclic derivatives derived from ethyl-2-hydroxyquinoxaline-3-carboxylate was written by Fernandes, P. S.;Sonar, T. M.. And the article was included in Journal of the Indian Chemical Society in 1986.Application of 49679-45-0 This article mentions the following:

The heterocyclic derivatives of morpholinoquinoxaine I (R = Ph, 4-MeOC₆H₄, 4-ClC₄H₄; X = O, S) and II were prepared from Et 2-chloroquinoxaline-3-carboxylate in 4 steps, and were tested for their antibacterial activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-{[4-(substituted 2-quinoxalinyloxy) phenyl] acetyl} glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity was written by Piras, Sandra;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 2004.Synthetic Route of C11H9ClN2O2 This article mentions the following:

Fourteen out of 21 quinoxaline derivatives described in the present paper were selected at NCI for evaluation of their in vitro anticancer activity. Preliminary screening showed that some derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10^-5 and 10^-4 M concentrations Interesting selectivities were also recorded between 10^-8 and 10^-6 M for the compounds 9 and 13. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Synthetic Route of C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Synthetic Route of C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Antidepressant potential of 5-HT₃ receptor antagonist, N-n- propyl-3-ethoxyquinoxaline-2-carboxamide (6n) was written by Mahesh, R.;Bhatt, S.;Devadoss, T.;Jindal, A. K.;Gautam, B. K.;Pandey, D. K.. And the article was included in Journal of Young Pharmacists in 2012.Related Products of 49679-45-0 This article mentions the following:

The present study was designed to evaluate the antidepressant potential of 5-HT3 receptor antagonist N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n). The compound “6n” with optimum log P and pA₂ value identified from a series of compounds synthesized in our laboratory was subjected to forced Swim Test (FST) (1, 2, and 4 mg/kg, i.p) and Tail Suspension Test (TST) (1, 2, and 4 mg/kg, i.p.). The compound “6n” significantly reduced the duration of immobility in mice without affecting the baseline locomotion. Moreover, “6n” (2 mg/kg, i.p.) potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and “6n” at tested dose (1 and 2 mg/kg, i.p.) reversed the reserpine-induced hypothermia in rats. In interaction studies of “6n” with various standard drugs/ligands using FST, “6n” (1 mg/kg, i.p.) potentiated the antidepressant effect of venlafaxine (4 and 8 mg/kg, i.p.) and fluoxetine (10 and 20 mg/kg, i.p.). Addnl., “6n” (1 and 2 mg/kg, i.p.) influenced the effect of harmane (5 mg/kg, i.p.) as well as reversed the effect of parthenolide (1 mg/kg, i.p.) by reducing the duration of immobility in FST. Furthermore, “6n” (1 mg/kg/, i.p.) potentiated the effect of bupropion (10 and 20 mg/kg, i.p.) in TST. Chronic “6n” (1 and 2 mg/kg, i.p.) treatment attenuated the behavioral abnormalities in olfactory bulbectomized rats. In conclusion, these various findings reiterated the antidepressant-like effects of “6n” in behavioral models of depression. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Related Products of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Related Products of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-l-glutamates as analogues-homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity was written by Piras, Sandra;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 2002.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)phenylacetyl-l-glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and biological activity of heterocyclic derivatives derived from ethyl-2-hydroxyquinoxaline-3-carboxylate was written by Fernandes, P. S.;Sonar, T. M.. And the article was included in Journal of the Indian Chemical Society in 1986.Application of 49679-45-0 This article mentions the following:

The heterocyclic derivatives of morpholinoquinoxaine I (R = Ph, 4-MeOC₆H₄, 4-ClC₄H₄; X = O, S) and II were prepared from Et 2-chloroquinoxaline-3-carboxylate in 4 steps, and were tested for their antibacterial activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider