Category: 49679-45-0

Application of 49679-45-0, New research progress on 49679-45-0 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a Patent，once mentioned of 49679-45-0

A herbicide containing a pyrimidine or triazine derivative of the formula (I): STR1 [wherein A is a furan ring, a pyrimidine ring, a 1,2,4-triazine ring or the like which may suitably be substituted, R is a hydroxyl group or a lower alkoxy group, each of R1 and R2 which may be the same or different, is a halogen atom, a lower alkyl group or a lower alkoxy group, W is an oxygen atom or a sulfur atom, and Z is nitrogen or a methine group] and its salt, as an active ingredient, is presented. The pyrimidine or triazine derivative of the present invention has excellent herbicidal effects against noxious weeds in paddy fields, upland fields and non-agricultural fields.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1885 | ChemSpider

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.49679-45-0, In a article, mentioned the application of 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2

Thirty quinoxalines bearing a substituted phenoxy or hydroxybenzoylglutamate group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate the in vitro anticancer activity. Screening over 21 compounds selected at the National Cancer Institute (Bethesda, MD) showed that only few derivatives exhibited a moderate growth inhibition activity on various tumor panel cell lines at 10-4 molar concentration. The acid derivatives showed no growth inhibition activity. The results obtained in this series seem to indicate that in general carboxy or carboethoxy groups close to O-link with phenyl or benzoyl glutamates on position 2 are detrimental for anticancer activity.

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Quinoxaline – Wikipedia,
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New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.HPLC of Formula: C11H9ClN2O2, In a article, mentioned the application of 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2

Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared In order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6 M for a few compounds. One single compound exhibited good activity against Candida albicans.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C11H9ClN2O2, you can also check out more blogs about49679-45-0

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Related Products of 49679-45-0, New research progress on 49679-45-0 in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article，once mentioned of 49679-45-0

The present invention provides a tri-substituted pyrimidine compound having an excellent PDE10 inhibitory activity. The present invention relates to a tri-substituted pyrimidine compound represented by the following formula [I0] or a pharmaceutically acceptable salt thereof, a method for preparing the same, and use of said compound for PDE10 inhibitor, and a pharmaceutical composition comprising said compounds as an active ingredient: wherein: either one of X1 and X2 is N, and the other of X1 and X2 is CH; A is *-CH?CH?, *-C(Alk)=CH?, *-CH2?CH2? or *-O?CH2? (* is a bond with R1); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R1 is an optionally substituted quinoxalinyl or an optionally substituted quinolyl; Y0 is mono- or di-substituted amino group, or a pharmaceutically acceptable salt thereof.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1884 | ChemSpider

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.Product Details of 49679-45-0, In a article, mentioned the application of 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2

Chloropyrimidines 2, 3 and Chlorquinazolines 9, 10, after conversion into trimethylammonio derivatives 4, 5, 11, 12, react with tetraethylammonium cyanide 1a under very mild conditions to give pyrimidine carbonitriles 6, 7 and quinazoline carbonitriles 13, 14.Direct synthesis of quinoxaline carbonitriles 19 is possible by reaction of chloroquinoxalines 15, 18 with 1a.

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Product Details of 49679-45-0, New Advances in Chemical Research in 2021. Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article，once mentioned of 49679-45-0

Ethyl-2-chloroquinoxaline-3-carboxylate obtained from ethyl-2-hydroxyquinoxaline-3-carboxylate upon treatment with morpholine gave ethyl-2-morpholinoquinoxaline-3-carboxylate (1).This ester upon reaction with hydrazine hydrate (99percent) gave respective carboxy hydrazide (2).This hydrazide on reaction with phenyl isothiocyanates gave thiosemicarbazides (3a-c).The thiosemicarbazides on reaction with concentrated sulphuric acid or anhydrous phosphoric acid gave 2-(4-substituted)-anilino-5-((2′-morpholino)quinoxalino)-1,3,4-thiadiazoles (4a-c).The thiosemicarbazides on reaction with 4percent sodium hydroxide formed 4-(para-substituted-phenyl)-3-mercapto-5-((2′-morpholino)quinoxalino)-1,2,4-triazoles (5a-c), and on reaction with I2 in KI gave 2-(4-substituted)anilino-5-((2′-morpholino)quinoxalino)-1,3,4-oxadiazoles (6a-c) respectively.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1894 | ChemSpider

49679-45-0, New research progress on 49679-45-0 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a Patent，once mentioned of 49679-45-0

The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered mono- cyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6- membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O-, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1886 | ChemSpider

New Advances in Chemical Research, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry.COA of Formula: C11H9ClN2O2, In a article, mentioned the application of 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2

Oxidation of 1H-pyrazolo<3,4-b>quinoxalines (1a: R=H, 1b: R=CH3) with m-chloroperbenzoic acid (MCPBA) gave the 4-oxides (2a, b).The structures of 2a, b were confirmed by synthesis, by condensing 2-chloroquinoxaline-3-carbaldehyde 4-oxide (6) with appropriate hydrazines.Further oxidation of 2a with MCPBA gave the 4,9-dioxide (8).Treatment of 1,2-dihydro-2-oxoquinoxaline-3-carboxamide (10) and 1,2-dihydro-2-oxoquinoxaline-3-carbonitrile 4-oxide (13) with a mixture of POCl3 and PCl5 or POCl3-dimethylformamide afforded 2-chloroquinoaline-3-carbonitrile (11) and its 4-oxide (14), respectively.When 11 and 14 were reacted with hydrazines, the correponding 3-amino-1H-pyrazolo<3,4-b>-quinoxalines (12a, b) and their 4-oxides (15a, b) were obtained in high yields.The reaction of ethyl 2-chloroquinoxaline-3-carboxylate (16) with hydrazine hydrate afforded a mixture of uncyclized products, N,N’-bis(2-ethoxycarbonyl-3-quinoxalinyl)hydrazine (17), ethyl 2-hydrazinoquinoxaline-3-carboxylate (18) and 2-hydrazinoquinoxaline-3-carbohydrazide (19).Keywords 1H-pyrazolo<3,4-b>quinoxaline 4-oxide; 1H-pyrazolo<3,4-b>quinoxaline 4,9-dioxide; 3-amino-1H-pyrazolo<3,4-b>quinoxaline 4-oxide; 2-chloroquinoxaline-3-carbaldehyde 4-oxide; hydrazine; N,N’-bis(2-ethoxycarbonyl-3-quinoxalinyl)hydrazine; ethyl 2-hydrazinoquinoxaline-3-carboxylate; 2-hydrazinoquinoxaline-3-carbohydrazide

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1911 | ChemSpider

Related Products of 49679-45-0, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article，once mentioned of 49679-45-0

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1880 | ChemSpider

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. Electric Literature of 49679-45-0, In a article, mentioned the application of 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2

Fourteen out of 21 quinoxaline derivatives described in the present paper were selected at NCI for evaluation of their in vitro anticancer activity. Preliminary screening showed that some derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 M concentrations. Interesting selectivities were also recorded between 10-8 and 10-6 M for the compounds 9 and 13.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 49679-45-0

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1908 | ChemSpider