Category: 49679-45-0

Related Products of 49679-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article£¬once mentioned of 49679-45-0

Synthesis and reactions of 1H-1,5-benzodiazepino-[2,3-b]quinoxaline, a new heterocyclic system

A convenient method for the synthesis of the new heterocyclic system, 1H-1, 5-benzodiazepino-[2,3-b]quinoxaline (1) and some of its derivatives are described.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1901 | ChemSpider

Reference of 49679-45-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a Patent£¬once mentioned of 49679-45-0

Quinoxaline signal pathway inhibitor as well as preparation method and application thereof (by machine translation)

The invention belongs to the field, of pharmaceutical chemistry and particularly provides a quinoxaline signal pathway inhibitor as well as a preparation method and application, of the quinoxaline signal pathway inhibitor. , The preparation method can prepare more quinoxaline compounds, has good anti-cancer effect, both in vitro and in vivo, and has good application prospects, in the aspects of anticancer new drug research and development and the like. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 49679-45-0

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Synthetic Route of 49679-45-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate, introducing its new discovery.

AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE

The present invention provides aromatic nitrogen-containing 6-membered ring compounds having execellent PDE10 inhibitory activity. The present invention relates to an aromatic nitrogen-containing 6-membered ring compound represented by the following formula [I 0 ] or a pharmaceutically acceptable salt thereof, a method for preparing the same, and use of said compounds for PDE10 inhibitors, and a pharmaceutical composition comprising said compounds as an active ingredient: Formula [I 0 ] wherein: X 1 , X 2 and X 3 each independently are N or CH, and at least two of X 1 , X 2 and X 3 are N; A is *-CH=CH-, *-C(Alk)=CH-, *-CH 2 -CH 2 – or *-O-CH 2 – (* is a bond with R 1 ); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R 1 is an optionally substituted nitrogen-containing heterocyclic group, a nitrogen-containing heterocyclic moiety of which is a moiety selected from the group consisting of quinoxalinyl, quinolyl, isoquinolyl, quinazolinyl, pyrazinyl, pyrimidinyl and a moiety thereof fused with a 5 to 6-membered aliphatic ring thereto; Y 0 is a group selected from the group consisting of the following (1) to (5): (1) an optionally substituted phenyl or an optionally substituted aromatic monocyclic 5 to 6-membered heterocyclic group; (2) an optionally substituted aminocarbonyl; (3) an optionally substituted amino lower alkyl; (4) -O-R 2 wherein R 2 is hydrogen, an optionally substituted lower alkyl, lower cycloalkyl, aliphatic monocyclic 5 to 6-membered heterocyclic group, or Formula [AA]; (5) mono- or di-substituted amino; provided that, when Y 0 is mono- or di-substituted amino, the nitrogen-containing heterocyclic moiety of R 1 is not quinoxalinyl or quinolyl

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 49679-45-0. In my other articles, you can also check out more blogs about 49679-45-0

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Application of 49679-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article£¬once mentioned of 49679-45-0

Synthesis and some reactions of quinoxalinecarboazides

Chlorination of ethyl(quinoxalin-2(1 H)one)-3-carboxylate 1 gave ethyl (2-chloroquinoxaline)-3-carboxylate 2;thionation of 1 by P2S5 or 2 by thiourea yielded the same product 3.Reaction of chloro compound 2 or thiocompound 3 with hydrazine hydrate gave pyrazolylquinoxaline 4. The reaction of ester 1 with thiourea or hydrazine hydrate afforded pyrimidoquinoxaline 5 or carbohydrazide 6; the reaction of 6 with carbon disulfide in basic medium followed by alkylation afforded oxadiazoloquinoxaline derivatives 7, 8a, b. Carboazide 9 was produced by reaction of 5 with nitrous acid. Compound 9 on heating in an inert solvent, with or without amines, in alcohols or hydrolysis in H2O undergoes Curtius rearrangments to yield 10-13.Reaction of 13 with thiosemicarbazide gave triazoloquinoxaline 14 which on reaction with alkylhalides or hydrazine hydrate yielded 15a-c while hydrolysis of 13 gave 3-aminoquinoxalinone 16 which was used as an intermediate to produce 17-20.

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Quinoxaline | C8H6N1905 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: quinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2

A Comparison of Nucleophilic Reactions of 3-Benzenesulfonyloxyalloxazine and its 1-Methyl Analog.

Reactions of 3-benzenesulfonyloxyalloxazine (1a) and its 1-methyl analog 1b with a number of nucleophilic reagents are reported.Relatively small nucleophiles, such as hydroxide ion, methanol, ethanol, methylamine, hydrazine and hydroxylamine converted 1a to 4-carboxy-s-triazolo<4,3-a>quinoxalin-1(2H)-ones and the corresponding esters or amides.As the size of the amine increased from methylamine to ethylamine, dimethylamine, propylamine and isopropylamine, there were obtained 4-(carboxamido)-s-triazolo<4,3-a>quinoxalin-1(2H)-ones, (1-carboxamido)imidazolo<4,5-b>quinoxalines and 2,3-bis(ureido)quinoxalines.Sodium hydride or potassium cyanide in hot DMF degraded 1a to imidazolo<4,5-b>quinoxaline.However, methylmercaptide and benzylmercaptide ions attacked the sulfonate group of 1a to form 3-hydroxyalloxazine. 1-Methyl-3-benzenesulfonyloxyalloxazine (1b) reacted with methanol, ethanol, 1-propanol, and to some degree 2-propanol, in the presence of triethylamine to furnish anhydro-1-hydroxy-3-methyl-4-(alkoxycarbonyl)-s-triazolo<4,3-a>quinoxalinium hydroxides.However, sodium methoxide in methanol converted this starting material to a mixture of anhydro-1-hydroxy-3-methyl-s-triazolo<4,3-a>quinoxalinium hydroxide and 1-methyl-3-hydroxyflavazole.A saturated aqueous solution of triethylamine transformed 1b to anhydro-1-hydroxy-3-methyl-s-triazolo<4,3-a>quinoxalinium hydroxide, apparently via the corresponding unstable 4-carboxylic acid.The reactions of 1b with a number of aliphatic amines yielded either amides based on the above mesionic system or on the 3-carboxamido-2-quinoxalyl semicarbazide structure.The reaction of 1b with potassium cyanide furnished 1-methylimidazolo<4,5-b>quinoxaline.Mechanisms to explain all of the degradations are advanced.

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Quinoxaline | C8H6N1896 | ChemSpider

49679-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article£¬once mentioned of 49679-45-0

Quinoxaline chemistry. Part 12. 3-Carboxy-2[phenoxyl-6(7)substituted quinoxalines and N-[4-(6(7) substituted-3-carboxyquinoxalin- 2-yl)hydroxy]-benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity

Thirty quinoxalines bearing a substituted phenoxy or hydroxybenzoylglutamate group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate the in vitro anticancer activity. Screening over 21 compounds selected at the National Cancer Institute (Bethesda, MD) showed that only few derivatives exhibited a moderate growth inhibition activity on various tumor panel cell lines at 10-4 molar concentration. The acid derivatives showed no growth inhibition activity. The results obtained in this series seem to indicate that in general carboxy or carboethoxy groups close to O-link with phenyl or benzoyl glutamates on position 2 are detrimental for anticancer activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 49679-45-0, In my other articles, you can also check out more blogs about 49679-45-0

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Chemistry is traditionally divided into organic and inorganic chemistry. 49679-45-0, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 49679-45-0

PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS

The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered mono- cyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6- membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O-, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor

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Quinoxaline | C8H6N1886 | ChemSpider

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate,introducing its new discovery., 49679-45-0

Rapid and convenient synthesis of original 5-substituted quinolino[3,4- b ]quinoxalin-6(5 H)-ones under eco-friendly conditions

We report herein the synthesis of 5-(substituted)quinolino[3,4-b]quinoxalin-6(5H)-one derivatives from ethyl 3-(2-bromophenyl)quinoxaline-2-carboxylate under one-pot Buchwald-Hartwig coupling-lactamization reaction.

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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

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Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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