Category: 532934-95-5

Prodrug Approach toward the Development of a PET Radioligand for Imaging the GluN2A Subunits of the NMDA Receptor was written by Gruber, Stefan;Waser, Valerie;Thiel, Zacharias;Ametamey, Simon M.. And the article was included in Organic Letters in 2021.Reference of 532934-95-5 This article mentions the following:

A straightforward synthesis of a F-18-labeled prodrug of AFA233 is reported. The key step in the preparation of [¹⁸F]AFA233-prodrug is the selective deprotection of the tert-Bu protection groups of the quinoxalinedione moiety without cleavage of the tert-butyl-S-acyl-2-thioethyl protection groups on the phosphate esters. The preparation of the nonradioactive prodrug reference compound of AFA233 is reported. In the experiment, the researchers used many compounds, for example, 7-Bromo-5-methylquinoxaline (cas: 532934-95-5Reference of 532934-95-5).

7-Bromo-5-methylquinoxaline (cas: 532934-95-5) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Reference of 532934-95-5

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The Nitration of 5-Methylquinoxalines in Mixed Acid was written by Marterer, Wolfgang;Prikoszovich, Walter;Wiss, Jacques;Prashad, Mahavir. And the article was included in Organic Process Research & Development in 2003.HPLC of Formula: 532934-95-5 This article mentions the following:

5-Methylquinoxalines are nitrated surprisingly efficiently at the 8 position following a simple nitration protocol with mixed acid at 40-50°. The implications of halogen functionalization at C-7 and modification of the mixed acid conditions on the relative rates of conversion and process safety are discussed. Competing side reactions for 7-halo-5-methylquinoxalines involve hydrolysis at C-7 and halogenation at C-6 or C-8. In the experiment, the researchers used many compounds, for example, 7-Bromo-5-methylquinoxaline (cas: 532934-95-5HPLC of Formula: 532934-95-5).

7-Bromo-5-methylquinoxaline (cas: 532934-95-5) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.HPLC of Formula: 532934-95-5

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider