Category: 55687-05-3

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.COA of Formula: C8H4Cl2N2, In a article, mentioned the application of 55687-05-3, Name is 2,5-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 2,5-Dichloroquinoxaline, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 55687-05-3, in my other articles.

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1620 | ChemSpider

New Advances in Chemical Research, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Recommanded Product: 55687-05-3, In a article, mentioned the application of 55687-05-3, Name is 2,5-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Disclosed are quinoxaline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): wherein: each of L1 and L2 is, independently, a bond, ?O? or ?NH?; R2 is C6-C10 aryl or heteroaryl including 5-10 atoms, each of which is (i) substituted with 1 R9, and (ii) optionally further substituted with from 1-4 Re; and each of R4 and R5 is, independently (i) hydrogen; or (ii) halo; or (iii) C1-C6 alkyl or C1-C6 haloalkyl, each of which is optionally substituted with from 1-3 Ra; and R1, R3, R6, R9, Ra and Re are defined herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 55687-05-3, and how the biochemistry of the body works.COA of Formula: C8H4Cl2N2

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1621 | ChemSpider

Safety of 2,5-Dichloroquinoxaline, New research progress on 55687-05-3 in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.55687-05-3, Name is 2,5-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a article，once mentioned of 55687-05-3

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of 2,5-Dichloroquinoxaline, you can also check out more blogs about55687-05-3

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1622 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C8H4Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 55687-05-3, Name is 2,5-Dichloroquinoxaline, molecular formula is C8H4Cl2N2

Antitumor compositions and methods of treatment

This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C8H4Cl2N2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 55687-05-3, in my other articles.

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1620 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of 2,5-Dichloroquinoxaline. Introducing a new discovery about 55687-05-3, Name is 2,5-Dichloroquinoxaline

Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469)

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 2,5-Dichloroquinoxaline, you can also check out more blogs about55687-05-3

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1622 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 55687-05-3, name is 2,5-Dichloroquinoxaline, introducing its new discovery. Computed Properties of C8H4Cl2N2

QUINOXALINE-BASED LXR MODULATORS

Disclosed are quinoxaline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): wherein: each of L1 and L2 is, independently, a bond, ?O? or ?NH?; R2 is C6-C10 aryl or heteroaryl including 5-10 atoms, each of which is (i) substituted with 1 R9, and (ii) optionally further substituted with from 1-4 Re; and each of R4 and R5 is, independently (i) hydrogen; or (ii) halo; or (iii) C1-C6 alkyl or C1-C6 haloalkyl, each of which is optionally substituted with from 1-3 Ra; and R1, R3, R6, R9, Ra and Re are defined herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 55687-05-3, and how the biochemistry of the body works.Computed Properties of C8H4Cl2N2

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1621 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-05-3,2,5-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 2 Preparation of 4-N’,N’-dimethylamino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide A suspension of sodium hydride (60%, 114 mg, 2.85 mmol) in N,N-dimethylformamide (10 ml) under nitrogen at room temperature was treated with p-dimethylaminobenzenesulfonamide (214 mg, 1.07 mmol), and after stirring one hour, solid 2,5-dichloroquinoxaline (231 mg, 1.16 mmol) was added. After stirring overnight, the reaction mixture was poured into water (100 ml) and the pH adjusted to 3-4 by the addition of 1N hydrochloric acid solution. The resulting precipitate was collected, dried and purified by silica gel flash chromatography (EtOAc/hexanes/THF) to yield the title product (56 mg, 14%) as a solid. Analysis of the title compound gave the following results: 1 H NMR (300 MHz, d6 -DMSO)delta2.92(s, 6H, CH3), 6.72 (d, 2H, J=7.8 Hz, Ar-H), 7.68-7.84 (overlapping multiplets, 3H, Ar-H), 7.85 (d, 2H, J=8.0 Hz, Ar-H), 8.61 (s, 1H, Ar-H), 11.78(s, 1H, exchanges with D2 O, NH); IR(KBr) 1600, 1582, 3.448, 1148 and 1089 cm-1; FDMS(DMSO) m/e=362, 364 (M+). Analysis of C16 H15 ClN4 O2 S: Theory: C, 52.96; H, 4.17; N, 15.44. Found: C, 53.17; H, 4.30; N, 15.30., 55687-05-3

55687-05-3 2,5-Dichloroquinoxaline 10679487, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Eli Lilly and Company; US5529999; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-05-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-05-3,2,5-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

Step 4: 2,5-dichloroquinoxaline (90 mg, 0.452 mmol), 3-bromophenol (86 mg, 0.497 mmol) and potassium carbonate (82 mg, 0.542 mmol) were heated to 90 C. in anhydrous acetonitrile (3 mL) for 18 hours. The reaction was allowed to cool to room temperature and transferred to a separatory funnel with ethyl acetate and washed with water, 1N aqueous sodium hydroxide solution, brine, dried (MgSO4), filtered, and the solvent removed in vacuo, to give an off white solid. This material was adsorbed onto silica and purified by column chromatography, eluding with a gradient of 0-25% ethyl acetate in hexane to afford 2-(3-bromophenoxy)-5-chloroquinoxaline as a white solid (130 mg, 86% Yield); MS (ESI) m/z 333.95087; HRMS: calcd for C14H8BrClN2O+H+, 334.9581. found (ESI, [M+H]+ Obs’d), 334.9583.

The synthetic route of 55687-05-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2010/120778; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider