Category: 57825-30-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.Synthetic Route of C9H7NO2. The article 《A one-pot procedure for the synthesis of aromatic aldehydes in a heterogeneous medium》 in relation to this compound, is published in Revista de Chimie (Bucharest, Romania). Let’s take a look at the latest research on this compound (cas:57825-30-6).

Aromatic aldehydes were obtained from halogenated compounds and DMSO in solvent free medium. The method involves a Kornblum’s oxidation of organic halide in mild conditions using microwaves. An inorganic base such as solid potassium bicarbonate is used. The procedure is a smooth alternative to obtain aromatic aldehydes in heterogeneous medium. The important benefits of the method are also the absence of catalysts, the low time, and the good yield of the synthesis.

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SDS of cas: 57825-30-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Phenylboronic acid-catalyzed tandem construction of S-S and C-S bonds: a new method for the synthesis of benzyl disulfanylsulfone derivatives from S-benzyl thiosulfonates. Author is Jannapu Reddy, Raju; Waheed, Md.; Rama Krishna, Gamidi.

A unique phenylboronic acid-catalyzed dimerization-sulfonylation of S-benzyl thiosulfonates has been disclosed. A metal-free tandem construction of S-S and C-S bonds is an operationally simple method to access a wide range of benzyl disulfanylsulfone derivatives I (Ar1 = C6H5, 4-ClC6H5, 1-naphthyl, etc.; Ar2 = C6H5, 4-MeOC6H5, 2-thienyl, etc.) in high to excellent yields. Moreover, the robustness of this tandem transformation has been demonstrated by gram-scale reactions, and a plausible mechanism is also proposed.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The effect of vinyl esters on the enantioselectivity of the lipase-catalyzed transesterification of alcohols, published in 2001-03-19, which mentions a compound: 57825-30-6, Name is 1-(Bromomethyl)-4-ethylbenzene, Molecular C9H11Br, Application In Synthesis of 1-(Bromomethyl)-4-ethylbenzene.

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol (I) was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alc. was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, resp. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalyzed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of I was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-I and then the enantioselective hydrolysis of the resultant ester to afford (S)-I.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Buchynskyy, Andriy; Gillespie, J. Robert; Hulverson, Matthew A.; McQueen, Joshua; Creason, Sharon A.; Ranade, Ranae M.; Duster, Nicole A.; Gelb, Michael H.; Buckner, Frederick S. researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).COA of Formula: C9H11Br.They published the article 《Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors》 about this compound( cas:57825-30-6 ) in Bioorganic & Medicinal Chemistry. Keywords: aminoethyl benzyloxyphenyl benzamide derivative preparation Trypanosoma brucei; Hit-to-lead optimization; Human African Trypanosomiasis; Trypanosoma brucei inhibitor; “Sleeping Sickness”. We’ll tell you more about this compound (cas:57825-30-6).

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-Ph benzamides as a starting point for hit-to-lead medicinal chem. Eighty two analogs were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50 = 0.001 μM. The compounds displayed drug-like properties when tested in a number of in vitro assays. Compound 73 was orally bioavailable and displayed good plasma and brain exposure in mice, cured 2 out of 3 mice infected with Trypanosoma brucei in acute model when dosed orally at 50 mg/kg once per day for 4 days. Given its potent antiparasitic properties and its ease of synthesis, compound 73 represents a potential lead for the development of drug to treat Human African Trypanosomiasis.

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Product Details of 57825-30-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors. Author is Buchynskyy, Andriy; Gillespie, J. Robert; Hulverson, Matthew A.; McQueen, Joshua; Creason, Sharon A.; Ranade, Ranae M.; Duster, Nicole A.; Gelb, Michael H.; Buckner, Frederick S..

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-Ph benzamides as a starting point for hit-to-lead medicinal chem. Eighty two analogs were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50 = 0.001 μM. The compounds displayed drug-like properties when tested in a number of in vitro assays. Compound 73 was orally bioavailable and displayed good plasma and brain exposure in mice, cured 2 out of 3 mice infected with Trypanosoma brucei in acute model when dosed orally at 50 mg/kg once per day for 4 days. Given its potent antiparasitic properties and its ease of synthesis, compound 73 represents a potential lead for the development of drug to treat Human African Trypanosomiasis.

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Qi, Zaojuan; Li, Weihe; Niu, Yanning; Benassi, Enrico; Qian, Bo published the article 《A General Method for the Dibromination of Vicinal sp3 C-H Bonds Exploiting Weak Solvent-Substrate Noncovalent Interactions》. Keywords: dibromoalkyl benzene preparation; arylethane dibromination.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Recommanded Product: 57825-30-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A general procedure of 1,2-dibromination of vicinal sp3 C-H bonds of arylethanes using N-bromosuccinimide as the bromide reagent without an external initiator was established. The modulation of the strength of the intermol. noncovalent interactions between the solvent and arylethane ethanes, quant. evaluated via quantum chem. calculations, allowed to circumvent the fact that arylethane ethane cannot be dibrominated through traditional methods. The mechanism was explored by both experiments and quantum chem. calculations, revealing a radical chain with HAA process.

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Yamamoto, Yasuo; Kawanishi, Eiji; Koga, Yuichi; Sakamaki, Shigeki; Sakamoto, Toshiaki; Ueta, Kiichiro; Matsushita, Yasuaki; Kuriyama, Chiaki; Tsuda-Tsukimoto, Minoru; Nomura, Sumihiro published the article 《N-glucosides as human sodium-dependent glucose co-transporter 2 (hSGLT2) inhibitors》. Keywords: urinary glucose amino glycoside preparation human hyperglycemia structure activity; amino glycoside preparation antidiabetic human SGLT2 inhibitor pharmacokinetic; Diabetes; Glucoside; N-glucoside; SGLT2; Sodium-dependent glucose cotransporter.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Computed Properties of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

Inhibition of renal sodium-dependent glucose co-transporter 2 (SGLT2) increases urinary glucose excretion (UGE), and thus reduces blood glucose levels in hyperglycemia. A series of N-glucosides was synthesized for biol. evaluation as human SGLT2 (hSGLT2) inhibitors. Among these compounds, N-glucoside 9d possessing an indole core structure showed good in vitro activity (IC50 = 7.1 nM against hSGLT2). Furthermore, 9d exhibited favorable in vivo potency with regard to UGE in rats based on good pharmacokinetic profiles.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 57825-30-6, is researched, SMILESS is CCC1=CC=C(CBr)C=C1, Molecular C9H11BrJournal, Article, Research Support, Non-U.S. Gov’t, European Journal of Medicinal Chemistry called Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase, Author is Chai, Xiaoyun; Zhang, Jun; Hu, Honggang; Yu, Shichong; Sun, Qingyan; Dan, Zhigang; Jiang, Yuanying; Wu, Qiuye, the main research direction is triazole preparation cytochrome P 450 14 alpha demethylase inhibitor; mol modeling triazole cytochrome P 450 14 alpha demethylase.Electric Literature of C9H11Br.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols I (R = H, 2-F, 2,4-Cl2, 4-MeO2C, PhO2C, etc.) as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. The MIC80 values indicate that compounds I (R = H, 2-F, 4-Me, etc.) exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole, while I (R = COOR1, R1 = Me, Et, iso-Pr, COOAr, etc.; Ar = Ph, 3-O2NC6H4, 4-ClC6H4, 2-MeO2CC6H4, etc.) showed no activity or only moderate activity against all fungi tested. Noticeably, the MIC value of I (R = H, 2-F, 4-Cl) is 64 times lower than that of fluconazole against Microsporum gypseum in vitro. And I (R = H, 2-F, CO2Et) showed 128 times higher activity (with the MIC80 value of 0.0039 μg/mL) than that of fluconazole against Candida albicans and also showed higher activity than that of the other pos. controls. Computational docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. In addition, the activity of the compounds would be enhanced when the side chains were shorter.

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Formula: C9H11Br. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about The effect of vinyl esters on the enantioselectivity of the lipase-catalyzed transesterification of alcohols. Author is Kawasaki, M.; Goto, M.; Kawabata, S.; Kometani, T..

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol (I) was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alc. was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, resp. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalyzed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of I was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-I and then the enantioselective hydrolysis of the resultant ester to afford (S)-I.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Design, synthesis and evaluation of 3-(imidazol-1-ylmethyl)indoles as antileishmanial agents. Part II, the main research direction is benzylimidazolylmethylindole preparation antileishmanial agent; indole benzylimidazolylmethyl preparation antileishmanial agent.Electric Literature of C9H11Br.

A new series of 1-benzyl-3-(imidazol-1-ylmethyl)indoles were synthesized according to a previous 3D-QSAR predictive model and assayed for their antiparasitic activity upon Leishmania mexicana promastigotes. The biol. results obtained for these twelve mols. showed an IC50 ranging from 2.3 to 32 μM and mainly illustrated the importance of the hydrophobic parameter in the para-position of the benzyl group. In order to improve the activities of these compounds and to check the potential influence of the electronic parameter on this particular position, a Craig diagram was used to select original electro-donating and lipophilic substituents. Synthesis and biol. evaluation of ten new compounds (IC50 between 2.5 and 5.4 μM) confirmed that only the hydrophobic field is essential for a high level of activity.

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