Category: 57825-30-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.Recommanded Product: (4-(Pyridin-4-yl)phenyl)methanol. The article 《Synthesis and biological studies of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives》 in relation to this compound, is published in Organic Communications. Let’s take a look at the latest research on this compound (cas:57825-30-6).

A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, 1H-NMR, 13C NMR, LCMS mass spectra and elemental anal.

Although many compounds look similar to this compound(57825-30-6)HPLC of Formula: 57825-30-6, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists, published in 2010-03-11, which mentions a compound: 57825-30-6, Name is 1-(Bromomethyl)-4-ethylbenzene, Molecular C9H11Br, Formula: C9H11Br.

Parathyroid hormone (PTH) is an effective bone anabolic agent. However, only when administered by daily s.c. injections exposure of short duration is achieved, a prerequisite for an anabolic response. Instead of applying exogenous PTH, mobilization of endogenous stores of the hormone can be envisaged. The secretion of PTH stored in the parathyroid glands is mediated by a calcium sensing receptor (CaSR) a GPCR localized at the cell surface. Antagonists of CaSR (calcilytics) mimic a state of hypocalcemia and stimulate PTH release to the bloodstream. Screening of the internal compound collection for inhibition of CaSR signaling function afforded 2a (I). In vitro potency could be improved > 1000 fold by optimization of its chem. structure. The binding mode of our compounds was predicted based on mol. modeling and confirmed by testing with mutated receptors. While the compounds readily induced PTH release after iv application a special formulation was needed for oral activity. The required profile was achieved by using microemulsions. Excellent PK/PD correlation was found in rats and dogs. High levels of PTH were reached in plasma within minutes which reverted to baseline in about 1-2 h in both species.

Although many compounds look similar to this compound(57825-30-6)Formula: C9H11Br, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives, Author is Xu, Yulan; Sheng, Chunquan; Wang, Wenya; Che, Xiaoying; Cao, Yongbing; Dong, Guoqiang; Wang, Shengzheng; Ji, Haitao; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian, which mentions a compound: 57825-30-6, SMILESS is CCC1=CC=C(CBr)C=C1, Molecular C9H11Br, Name: 1-(Bromomethyl)-4-ethylbenzene.

In an attempt to find novel azole antifungal agents with improved activity and broader spectrum, computer modeling was used to design a series of new azoles with piperidin-4-one O-substituted oxime side chains. Mol. docking studies revealed that they formed hydrophobic and hydrogen-bonding interactions with lanosterol 14α-demethylase of Candida albicans (CACYP51). In vitro antifungal assay indicates that most of the synthesized compounds showed good activity against tested fungal pathogens. In comparison with fluconazole, itraconazole and voriconazole, several compounds (such as I, R = H, 3-Cl, 2-F) show more potent antifungal activity and broader spectrum, suggesting that they are promising leads for the development of novel antifungal agents.

Although many compounds look similar to this compound(57825-30-6)Name: 1-(Bromomethyl)-4-ethylbenzene, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Synthesis and biological studies of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives.Electric Literature of C9H11Br.

A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, 1H-NMR, 13C NMR, LCMS mass spectra and elemental anal.

Although many compounds look similar to this compound(57825-30-6)Electric Literature of C9H11Br, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Mechanism of aromatic side-chain reactions with special reference to the polar effects of substituents. IV. The mechanism of quaternary salt formation》. Authors are Baker, John W.; Nathan, Wilfred S..The article about the compound:1-(Bromomethyl)-4-ethylbenzenecas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1).Formula: C9H11Br. Through the article, more information about this compound (cas:57825-30-6) is conveyed.

cf. C. A. 29, 4657.5. The following data are given for the reaction of RC6H4CH2Br with C5H5N in dry Me2CO at the temperatures given, where R is: p-Me, 20°, 2.020 (kp × 104, g.-mol./l./sec.); 40°, 7.983; p-Et, 20°, 1.811; 30°, 3.517; 40°, 6.733; p-iso-Pr, 20°, 1.633; 40°, 6.500; p-tert-Bu, 20°, 1.652; 30°, 3.357; 40°, 6.467; 2,4-Me2, 20°, 6.287; 30°, 12.48; 40°, 24.05; 2,4-(NO2)2, 20°, 2.288; 30°, 4.700; 40°, 8.960. The results show that the small retarding effect of a p-NO2 group is replaced by an accelerating effect when a 2nd NO2 group is introduced into the 2-position. In a series of substituents arranged in order of decreasing +I or increasing -I effects, a min. velocity is found with the p-NO2 compound: 2,4-Me2 > (p-tert-Bu < p-iso-Pr < p-Et < p-Me) > H > p-NO2 ≪ 2,4-(NO2)2. The position of the 2,4-(NO2)2 group illustrates a new phenomenon, viz., the occurrence of a min. velocity in a graded polar series without change in reaction kinetics. The interaction of the 2,4-dinitrobenzyl bromide with C5H5N is strictly bimol., the velocity coefficient in Me2CO at 40° being independent of the concentration The accelerating effect of the 2,4-(NO2)2 groups observed in dry Me2CO is almost absent in aqueous 90% Me2CO and becomes a retarding effect in aqueous 90% EtOH. The results thus far show (1) the reaction between benzyl halides and tert-bases in non-aqueous media is strictly bimol. and involves a simultaneous addition and dissociation; the Arrhenius energy of activation E is, within exptl. error, unaffected by substituents and is closely related to the energy changes involved in the electron cycle as a whole; the velocity of the reaction, as affected by substituent groups in the aryl bromide, is determined mainly by some factor which is incorporated in the term P of the equation kp = PZe-E/RT; electron accession toward the side chain (+I effect) increases the reaction velocity; up to a point (at p-NO2), decrease of electron availability in the side chain decreases the velocity, but greater electron recession (in 2,4-(NO2)2) from the side chain to the nucleus reverses this effect and greatly increases the velocity. 2,4-Dinitrobenzylpyridinium bromide, m. 196° (decomposition). p-Ethylbenzyl bromide, b0.8 84°, m. 14.5-5.2°, from the chloride and NaBr in 90% aqueous Me2CO; iso-Pr homolog, b0.4 75°; tert-Bu homolog, b0.3 99°, m. 15.1°; 2,4-dimethylbenzyl bromide, b1.2 79°, m. 15°.

Although many compounds look similar to this compound(57825-30-6)Formula: C9H11Br, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Category: quinoxaline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. Author is Xu, Yulan; Sheng, Chunquan; Wang, Wenya; Che, Xiaoying; Cao, Yongbing; Dong, Guoqiang; Wang, Shengzheng; Ji, Haitao; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian.

In an attempt to find novel azole antifungal agents with improved activity and broader spectrum, computer modeling was used to design a series of new azoles with piperidin-4-one O-substituted oxime side chains. Mol. docking studies revealed that they formed hydrophobic and hydrogen-bonding interactions with lanosterol 14α-demethylase of Candida albicans (CACYP51). In vitro antifungal assay indicates that most of the synthesized compounds showed good activity against tested fungal pathogens. In comparison with fluconazole, itraconazole and voriconazole, several compounds (such as I, R = H, 3-Cl, 2-F) show more potent antifungal activity and broader spectrum, suggesting that they are promising leads for the development of novel antifungal agents.

Although many compounds look similar to this compound(57825-30-6)Category: quinoxaline, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya called Competing electrophilic aromatization of methylene-1,3- and -1,4-cyclohexadienes, Author is Rozenberg, V. I.; Nikanorov, V. A.; Gorbacheva, R. I.; Reutov, O. A., which mentions a compound: 57825-30-6, SMILESS is CCC1=CC=C(CBr)C=C1, Molecular C9H11Br, SDS of cas: 57825-30-6.

Reaction of 5:1 5-ethyl-6-methylene-1,3- (I) and 3-ethyl-6-methylene-1,4-cyclohexadiene (II) with HgCl2 followed by reduction with LiAlH4 gave 5:1 2- (III) and 4-EtC6H4Me (IV) in 90% overall yield. Adding a 10-fold excess of HCl gave 50:1 III-IV. Reaction of 5:1 I-II with AuBr3 or (Ph3P)AuBr3 gave 3.8:1 III-IV in 17 and 85% combined yield, resp.

Although many compounds look similar to this compound(57825-30-6)SDS of cas: 57825-30-6, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Qiao; Wang, Simin; Zhang, Qian; Xiong, Tao published the article 《Radical Addition-Triggered Remote Migratory Isomerization of Unactivated Alkenes to Difluoromethylene-Containing Alkenes Enabled by Bimetallic Catalysis》. Keywords: difluoromethyl alkene preparation diastereoselective; alkene radical addition isomerization.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Reference of 1-(Bromomethyl)-4-ethylbenzene. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A fascinating alkene remote migratory isomerization engendered by carbon radical addition to C=C bond in alkenes Ar(CH2)nCH=CH2 (Ar = C6H5, 4-FC6H4, 2-pyridyl, etc.; n = 2, 4, 5, 6, 7) via bimetallic catalysis has been disclosed. A diverse array of alkenes bearing distantly incorporated the difluoromethylene ArCH=CH(CH2)mCF2C(O)R (m = 1, 4, 5, 6, 9; R = OMe, OEt, morpholin-4-yl, etc.) functionality have been expediently obtained. The retainment of C=C bonds in products could serve as an useful synthetic platform furnishing otherwise difficult to access value-added densely functionalized difluoromethylene containing mols. In addition, some exptl. studies have been implemented to shed light on the probable mechanism.

Although many compounds look similar to this compound(57825-30-6)Reference of 1-(Bromomethyl)-4-ethylbenzene, numerous studies have shown that this compound(SMILES:CCC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.Recommanded Product: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. The article 《Synthesis of 5-(bis((5-phenyl-1,3,4-oxadiazol-2-yl)methylthio)methylene)-2-(4-substituted benzylthio)-pyrimidine-4,6-(1H,5H)-dione derivatives》 in relation to this compound, is published in Chemija. Let’s take a look at the latest research on this compound (cas:57825-30-6).

The title compounds I (R = Ph, 4-BrC6H4, 4-EtC6H4, etc.) were synthesized via the three-component coupling of thiobarbituric acid with CS2 and 2-chloromethyl-5-phenyl-1,3,4-oxadiazole followed by S-alkylation of the resultant intermediate with benzyl halides. The newly synthesized compounds were characterized by 1H NMR, 13C NMR, mass, IR and elemental anal.

Compounds in my other articles are similar to this one(1-(Bromomethyl)-4-ethylbenzene)Electric Literature of C9H11Br, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues. Author is Mei, Tie-Wen; Luo, Yu; Feng, Xiang-Jun; Lu, Wei; Yang, Bo.

A concise synthesis of Fingolimod (FTY720) and its analogs was described. The key step involved Suzuki coupling of aryl boronate 11 with different bromides. In addition, the newly synthesized Fingolimod analogs were evaluated for their in vitro cytotoxicity against SMCC-7721 and HL-60 cell lines. The preliminary SAR was discussed.

Compounds in my other articles are similar to this one(1-(Bromomethyl)-4-ethylbenzene)Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider