Category: 57825-30-6

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase, published in 2009-05-31, which mentions a compound: 57825-30-6, Name is 1-(Bromomethyl)-4-ethylbenzene, Molecular C9H11Br, Safety of 1-(Bromomethyl)-4-ethylbenzene.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols I (R = H, 2-F, 2,4-Cl2, 4-MeO2C, PhO2C, etc.) as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. The MIC80 values indicate that compounds I (R = H, 2-F, 4-Me, etc.) exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole, while I (R = COOR1, R1 = Me, Et, iso-Pr, COOAr, etc.; Ar = Ph, 3-O2NC6H4, 4-ClC6H4, 2-MeO2CC6H4, etc.) showed no activity or only moderate activity against all fungi tested. Noticeably, the MIC value of I (R = H, 2-F, 4-Cl) is 64 times lower than that of fluconazole against Microsporum gypseum in vitro. And I (R = H, 2-F, CO2Et) showed 128 times higher activity (with the MIC80 value of 0.0039 μg/mL) than that of fluconazole against Candida albicans and also showed higher activity than that of the other pos. controls. Computational docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. In addition, the activity of the compounds would be enhanced when the side chains were shorter.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Design, synthesis and activity evaluation of 9-substituted-2-amino-6-guanidinopurines as acrosin inhibitors.Reference of 1-(Bromomethyl)-4-ethylbenzene.

Acrosin, a trypsin-like endoprotease, present in the acrosome of spermatozoa, is a promising target for contraceptive agents. Based on the previous homol. modeling and the anal. of the properties of the activity site of human acrosin, a series of 9-substituted-2-amino-6-guanidinopurines were designed and synthesized on a scaffold represented by KF950. The structures of all the title compounds were confined by 1H NMR, MS, IR and elemental anal. Intermediate 5m was determined by single crystal X-ray diffraction anal. The inhibitory activities against acrosin of all target compounds were tested in vitro and all of them exhibited much more inhibitory activities against acrosin, resp., with pos. control, TLCK. Compound 6z exhibited similar inhibitory activities against KF950.

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Zhang, Xiao-Meng; Zhu, Ju; Liu, Xue-Fei; Sheng, Chun-Quan; Zheng, Can-Hui; Fu, Xiao-Dan; Song, Yun-Long; Zhou, You-Jun; Lu, Jia-Guo published an article about the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1 ).SDS of cas: 57825-30-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:57825-30-6) through the article.

Acrosin, a trypsin-like endoprotease, present in the acrosome of spermatozoa, is a promising target for contraceptive agents. Based on the previous homol. modeling and the anal. of the properties of the activity site of human acrosin, a series of 9-substituted-2-amino-6-guanidinopurines were designed and synthesized on a scaffold represented by KF950. The structures of all the title compounds were confined by 1H NMR, MS, IR and elemental anal. Intermediate 5m was determined by single crystal X-ray diffraction anal. The inhibitory activities against acrosin of all target compounds were tested in vitro and all of them exhibited much more inhibitory activities against acrosin, resp., with pos. control, TLCK. Compound 6z exhibited similar inhibitory activities against KF950.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, the main research direction is triazolyl difluorophenyl aralkylamino propanol preparation antifungal activity computational chem.Application of 57825-30-6.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, e.g., I, as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Design, synthesis and evaluation of 3-(imidazol-1-ylmethyl)indoles as antileishmanial agents. Part II.Safety of 1-(Bromomethyl)-4-ethylbenzene.

A new series of 1-benzyl-3-(imidazol-1-ylmethyl)indoles were synthesized according to a previous 3D-QSAR predictive model and assayed for their antiparasitic activity upon Leishmania mexicana promastigotes. The biol. results obtained for these twelve mols. showed an IC50 ranging from 2.3 to 32 μM and mainly illustrated the importance of the hydrophobic parameter in the para-position of the benzyl group. In order to improve the activities of these compounds and to check the potential influence of the electronic parameter on this particular position, a Craig diagram was used to select original electro-donating and lipophilic substituents. Synthesis and biol. evaluation of ten new compounds (IC50 between 2.5 and 5.4 μM) confirmed that only the hydrophobic field is essential for a high level of activity.

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Khurana, Jitender M.; Maikap, Golak C. published an article about the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1 ).Related Products of 57825-30-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:57825-30-6) through the article.

Bromomethylation of aromatics mediated by low frequency ultrasound yielded bromomethylated aromatic rings which are useful synthetic intermediates. E.g., PhMe was bromomethylated with paraformaldehyde, 48% aqueous HBr and glacial HOAc on exposure to ultrasound to give 90% 4-methylbenzyl bromide. Among the 7 other compounds similarly prepared were 93% 2,5-dimethylbenzyl bromide, 93% 4-ethylbenzyl bromide, 92% 1-bromomethylnaphthalene and 95% 1-bromomethyl-2-methylnaphthalene.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.Recommanded Product: 57825-30-6.Yu, Shichong; Chai, Xiaoyun; Hu, Honggang; Yan, Yongzheng; Guan, Zhongjun; Zou, Yan; Sun, Qingyan; Wu, Qiuye published the article 《Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase》 about this compound( cas:57825-30-6 ) in European Journal of Medicinal Chemistry. Keywords: triazole preparation inhibitor cytochrome P 450 14 alpha demethylase; click reaction triazole preparation antifungal evaluation. Let’s learn more about this compound (cas:57825-30-6).

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols, which are analogs of fluconazole, have been designed and synthesized as the potential antifungal agents by the click reaction. Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked triazole antifungal derivatives was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of propargylated intermediates with substituted benzyl or alkyl azides. The 1,2,3-triazolyl group was inserted into the side chain of the target mol. which can increase the antifungal activity of compounds

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COA of Formula: C9H11Br. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Direct conversion of alkyl halides into benzimidazoles using pyridine-N-oxide and 1,2-diaminobenzenes.

Benzimidazole heterocycles I [R1 = C6H5, 4-CH3CH2C6H4, 4-FC6H4, 1H-pyrrol-2-yl, etc.; R2 = H, 5-OCH3, 5-CH3] were obtained from halogenated compounds R1CH2Br and aromatic 1,2-diamines such as o-phenylenediamine, 4-methyl-1,2-benzenediamine, 4-methoxy-1,2-benzenediamine. A mild oxidizing reagent such as pyridine N-oxide is required to produce the benzimidazole core I. The method is solvent-free and provides products without the need for chromatog. Good yields, moderate reaction temperature, and fast reaction rates are important advantages of this procedure.

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Matharu, Daljit S.; Flaherty, Daniel P.; Simpson, Denise S.; Schroeder, Chad E.; Chung, Donghoon; Yan, Dan; Noah, James W.; Jonsson, Colleen B.; White, E. Lucile; Aube, Jeffrey; Plemper, Richard K.; Severson, William E.; Golden, Jennifer E. published the article 《Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity》. Keywords: quinazolinedione inhibitor respiration syncytial virus RNA polymerase.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).COA of Formula: C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability (selectivity index, SI ∼ 24). Scaffold optimization delivered analogs with improved potency and selectivity profiles. Most notable were compounds 15 and 19 (EC50 = 300-500 nM, CC50 > 50 μM, SI > 100), which significantly reduced viral titer (>400,000-fold), and several analogs were shown to block the activity of the RNA-dependent RNA-polymerase complex of RSV.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.Computed Properties of C16H16Cl2Cu2. The article 《Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:57825-30-6).

In an attempt to find novel azole antifungal agents with improved activity and broader spectrum, computer modeling was used to design a series of new azoles with piperidin-4-one O-substituted oxime side chains. Mol. docking studies revealed that they formed hydrophobic and hydrogen-bonding interactions with lanosterol 14α-demethylase of Candida albicans (CACYP51). In vitro antifungal assay indicates that most of the synthesized compounds showed good activity against tested fungal pathogens. In comparison with fluconazole, itraconazole and voriconazole, several compounds (such as I, R = H, 3-Cl, 2-F) show more potent antifungal activity and broader spectrum, suggesting that they are promising leads for the development of novel antifungal agents.

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