Category: 57825-30-6

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Shuai; Xiao, Jun-Zhao; Li, Yan-Bo; Shi, Chang-Yun; Yin, Liang researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Related Products of 57825-30-6.They published the article 《Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines》 about this compound( cas:57825-30-6 ) in Journal of the American Chemical Society. Keywords: chiral benzyldiarylphosphine sulfide preparation crystal structure; crystal structure chiral benzyldiarylphosphine sulfide bisphosphine copper bridging halide; mol structure chiral benzyldiarylphosphine sulfide bisphosphine copper bridging halide; bisphosphine copper bridging halide cage complex preparation crystal structure; phosphorus stereogenic chiral tertiary phosphine sulfide preparation. We’ll tell you more about this compound (cas:57825-30-6).

A Cu(I)-catalyzed asym. alkylation of HPAr1Ar2 with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr1Ar2) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some 31P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr1Ar2 does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,RP)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.Quality Control of 1-(Bromomethyl)-4-ethylbenzene.Yu, Shichong; Chai, Xiaoyun; Hu, Honggang; Yan, Yongzheng; Guan, Zhongjun; Zou, Yan; Sun, Qingyan; Wu, Qiuye published the article 《Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase》 about this compound( cas:57825-30-6 ) in European Journal of Medicinal Chemistry. Keywords: triazole preparation inhibitor cytochrome P 450 14 alpha demethylase; click reaction triazole preparation antifungal evaluation. Let’s learn more about this compound (cas:57825-30-6).

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols, which are analogs of fluconazole, have been designed and synthesized as the potential antifungal agents by the click reaction. Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked triazole antifungal derivatives was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of propargylated intermediates with substituted benzyl or alkyl azides. The 1,2,3-triazolyl group was inserted into the side chain of the target mol. which can increase the antifungal activity of compounds

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Dier Junyi Daxue Xuebao called Synthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-butyl-N-substituted benzylamino)-2-propanol, Author is Wei, Ning; Zhao, Xiao-zhong; Chai, Xiao-yun; Guan, Zhong-jun; Dan, Zhi-gang; Yu, Shi-chong; Wu, Qiu-ye, which mentions a compound: 57825-30-6, SMILESS is CCC1=CC=C(CBr)C=C1, Molecular C9H11Br, Name: 1-(Bromomethyl)-4-ethylbenzene.

To study the antifungal activity of triazole alcs. by introducing N-Bu and substituted benzyl as side chain, fourteen title compounds were synthesized and characterized by 1H NMR, IR, and LC-MS. The MICs of the compounds were determined by in vitro test using 8 clin. pathogenic fungi. The title compounds exhibited potent antifungal activities against nearly all fungi tested (except for Aspergillus fumigatus), especially for the deep infection ones. Three compounds showed a 16-fold activity (with a MIC80 value of 0.015 6 μg/mL) as that of fluconazole against Microsporum gypseum. Two compounds showed a 128-fold activity (with a MIC80 value of 0.003 9 μg/mL) as that of fluconazole against Candida albicans, and their activities were higher than those of other pos. controls.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enzyme-Linked Immunosorbent Assay Detection of Pyrrolizidine Alkaloids: Immunogens Based on Quaternary Pyrrolizidinium Salts, published in 1996-04-30, which mentions a compound: 57825-30-6, Name is 1-(Bromomethyl)-4-ethylbenzene, Molecular C9H11Br, Quality Control of 1-(Bromomethyl)-4-ethylbenzene.

Polyclonal antibody-based enzyme-linked immunosorbent assays (ELISAs) were developed for the detection of retrorsine (1, 351 g/mol), monocrotaline (2, 325 g/mol), and retronecine (3, 155 g/mol) in the ppb range. A set of three bifunctional linking arms was synthesized. By N-alkylation of pyrrolizidine alkaloids (PAs) retrorsine, monocrotaline, and retronecine acetonide, six haptens were synthesized and used to generate rabbit antisera. The resulting anti-retrorsine antiserum gave a 50% inhibition (I50) value of 0.9 ppb for retrorsine with detection limits of 0.5-10 ppb. The same ELISA system also detected isatidine (retrorsine N-oxide) dihydrate (403 g/mol) with an I50 of 1 ppb and senecionine (352 g/mol) with an I50 of 100 ppb. A second monocrotaline-based ELISA detected monocrotaline with an I50 of 36 ppb 2 with detection limits of 5-500 ppb and shows no cross-reactivity with 1 or senecionine; this ELISA demonstrates the potential for the substrate-specific detection method. A third retronecine-based ELISA detects 3 with an I50 of 3000 ppb (3 ppm) and detection limits of 600-10,000 ppb. None of these ELISAs cross-react with the structurally similar swainsonine or lupinine alkaloids. PAs were detected in extracts of Senecio vulgaris and Crotalaria retusa, but not in Lupinus spp., as a demonstration of the ELISA’s usefulness.

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Application In Synthesis of 1-(Bromomethyl)-4-ethylbenzene. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1). Author is Deng, Yongqi; Yang, Zhiwei; Shipps, Gerald W.; Lo, Sie-Mun; West, Robert; Hwa, Joyce; Zheng, Shuqin; Farley, Constance; Lachowicz, Jean; van Heek, Margaret; Bass, Alan S.; Sinha, Dinesh P.; Mahon, Craig R.; Cartwright, Mark E..

Inhibitors based on a benzo-fused spirocyclic oxazepine scaffold were discovered for stearoyl-CoA (CoA) desaturase 1 (SCD1) and subsequently optimized to potent compounds with favorable pharmacokinetic profiles and in vivo efficacy in reducing the desaturation index in a mouse model. Initial optimization revealed potency preferences for the oxazepine core and benzylic positions, while substituents on the piperidine portions were more tolerant and allowed for tuning of potency and PK properties. After preparation and testing of a range of functional groups on the piperidine nitrogen, three classes of analogs were identified with single digit nanomolar potency: glycine amides, heterocycle-linked amides, and thiazoles. Responding to concerns about target localization and potential mechanism-based side effects, an initial effort was also made to improve liver concentration in an available rat PK model. An advanced compound 17m with a 5-carboxy-2-thiazole substructure appended to the spirocyclic piperidine scaffold was developed which satisfied the in vitro and in vivo requirements for more detailed studies.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols.Product Details of 57825-30-6.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, e.g., I, as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Rozenberg, V. I.; Gorbacheva, R. I.; Nikanorov, V. A.; Bundel, Yu. G.; Reutov, O. A. researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).HPLC of Formula: 57825-30-6.They published the article 《Addition-splitting off during bromination of olefins》 about this compound( cas:57825-30-6 ) in Zhurnal Organicheskoi Khimii. Keywords: bromination methylenecyclohexadiene; cyclohexadiene methylene bromination; toluene bromo ethyl; aromatization bromination methylenecyclohexadiene. We’ll tell you more about this compound (cas:57825-30-6).

Bromination of a 3:1 mixture of I-II at -20° in an inert atm gave a mixture of III and IV in a 3:1 molar ratio; p- and o-EtC6H4Me were inert to bromination under these conditions excluding the possibility of aromatization followed by bromination.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Synthesis of 5-(bis((5-phenyl-1,3,4-oxadiazol-2-yl)methylthio)methylene)-2-(4-substituted benzylthio)-pyrimidine-4,6-(1H,5H)-dione derivatives.Related Products of 57825-30-6.

The title compounds I (R = Ph, 4-BrC6H4, 4-EtC6H4, etc.) were synthesized via the three-component coupling of thiobarbituric acid with CS2 and 2-chloromethyl-5-phenyl-1,3,4-oxadiazole followed by S-alkylation of the resultant intermediate with benzyl halides. The newly synthesized compounds were characterized by 1H NMR, 13C NMR, mass, IR and elemental anal.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 57825-30-6, is researched, Molecular C9H11Br, about Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design, the main research direction is S1P1 agonist oxazole triazole preparation pharmacophore modeling structure activity; Immunomodulator; Lymphocyte; Pharmacophore; Prodrug; S1P(1) agonist.Formula: C9H11Br.

We have discovered a series of triazole/oxazole-containing 2-substituted 2-aminopropane-1,3-diol derivatives as potent and selective S1P1 agonists (prodrugs) based on pharmacophore-guided rational design. Most compounds showed high affinity and selectivity for S1P1 receptor. Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate. These three compounds were also identified to have favorable pharmacokinetic properties.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus, the main research direction is Ipragliflozin ASP1941 aryl glucoside benzothiophene preparation antidiabeteic SGLT2 mellitus.Computed Properties of C9H11Br.

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative I (R =H) was found to have potent inhibitory activity against SGLT2 and good selectivity vs. SGLT1. Through further optimization of 14a, a novel benzothiophene derivative I (R = F) (ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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