Category: 57825-30-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.Name: Chloro(1,5-cyclooctadiene)copper(I) dimer. The article 《Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:57825-30-6).

A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229, I) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clin. development.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Bromomethylation of aromatic compounds》. Authors are Nazarov, I. N.; Semenovskii, A. V..The article about the compound:1-(Bromomethyl)-4-ethylbenzenecas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1).Synthetic Route of C9H11Br. Through the article, more information about this compound (cas:57825-30-6) is conveyed.

Passage of HBr into 150 ml. MePh, 15 g. paraformaldehyde, 8.5 g. ZnCl2, and a little P 1 hr. at 50° gave after washing with NaHCO3 and H2O, 58% mixed MeC6H4CH2Br isomers (I), b10 82-90°, and some diaryl derivatives b13 145-50°. Passage of HBr into 150 ml. CCl4, 15 g. paraformaldehyde, and 10 g. ZnCl2 with a little P for 35 min. and dropwise addition of 53 g. EtPh at 50° in a continuous stream of HBr over 1.3 hrs. similarly gave 48.3% mixed EtC6H4CH2Br (II), b7.5 96-100°. Passage of HBr 6 hrs. into 90 ml. concentrated HBr, 70 g. MePh, 30 g. paraformaldehyde, and a little P, followed by 19 hrs. at 50° gave, after washing, 71.3% mixed MeC6H4CH2Br, b23 112-20°; similarly, EtPh gave 85% mixed EtC6H4CH2Br, b10 101-4°, while iso-PrPh gave 78% mixed iso-PrC6H4CH2Br (III), b20 126-30°. Hydrolysis of I gave mixed o- and p-MeC6H4CH2OH, b12 106-10°; II gave the corresponding Et analogs, b12 120-4° and III gave mixed iso-Pr analogs, b12 121-5°. The hydrolyses were run with chalk in hot H2O 24 hrs. Oxidation of the alcs. with CrO3 gave mixtures of o- and p-C6H4(CO2H)2; oxidation with 10% HNO3 in an autoclave at 200° gave the same products, in which the p-isomers predominated.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.Product Details of 57825-30-6.Wei, Ning; Zhao, Xiao-zhong; Chai, Xiao-yun; Guan, Zhong-jun; Dan, Zhi-gang; Yu, Shi-chong; Wu, Qiu-ye published the article 《Synthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-butyl-N-substituted benzylamino)-2-propanol》 about this compound( cas:57825-30-6 ) in Dier Junyi Daxue Xuebao. Keywords: triazole difluorophenyl butylbenzylamino propanol preparation antifungal agent. Let’s learn more about this compound (cas:57825-30-6).

To study the antifungal activity of triazole alcs. by introducing N-Bu and substituted benzyl as side chain, fourteen title compounds were synthesized and characterized by 1H NMR, IR, and LC-MS. The MICs of the compounds were determined by in vitro test using 8 clin. pathogenic fungi. The title compounds exhibited potent antifungal activities against nearly all fungi tested (except for Aspergillus fumigatus), especially for the deep infection ones. Three compounds showed a 16-fold activity (with a MIC80 value of 0.015 6 μg/mL) as that of fluconazole against Microsporum gypseum. Two compounds showed a 128-fold activity (with a MIC80 value of 0.003 9 μg/mL) as that of fluconazole against Candida albicans, and their activities were higher than those of other pos. controls.

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Recommanded Product: 57825-30-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about An efficient synthesis of benzyl bromides from aromatic aldehydes using polymethylhydrosiloxane and (bromodimethyl)sulfonium bromide or N-bromosuccinimide. Author is Das, Biswanath; Srinivas, Yallamalla; Holla, Harish; Laxminarayana, Keetha; Narender, Ravirala.

Polymethylhydrosiloxane (PMHS) in combination with (bromodimethyl)sulfonium bromide or NBS was utilized for the first time for reductive bromination of aromatic aldehydes at room temperature to afford the corresponding benzyl bromides in excellent yields.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Synthesis of Isothiochroman-3-ones via Metal-Free Oxidative Cyclization of Alkynyl Thioethers, the main research direction is isothiochromanone preparation metal free oxidative cyclization alkynyl thioether.Reference of 1-(Bromomethyl)-4-ethylbenzene.

A novel Bronsted acid-catalyzed oxidative C-H functionalization of alkynyl thioethers has been developed. This method allows the practical synthesis of valuable isothiochroman-3-ones in mostly moderate to good yields under mild reaction conditions and features a broad substrate scope and wide functional group tolerance. Moreover, this metal-free oxidation can also be used to promote formal N-H insertion involving an unexpected 1,2-sulfur migration, affording useful 1,4-benzothiazin-3-ones.

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Name: 1-(Bromomethyl)-4-ethylbenzene. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Polymer-supported reagents: polar effects in substrate selectivity. Author is Cainelli, Gianfranco; Contento, Michele; Manoscalchi, Francsco; Plessi, Laura.

A selectivity effect was observed in the competitive reaction of a polymer-supported nucleophile with pairs of halides of analogous size but different polarity. Competitive esterification with Amberlyst A-26 (AcO-) of Br(CH2)4CO2Et and Me(CH2)7Br showed a marked preference for the halide with a polar tail, the relative rates being 1.9 and 1.0, resp.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ) is researched.Safety of 1-(Bromomethyl)-4-ethylbenzene.Chai, Xiaoyun; Zhang, Jun; Yu, Shichong; Hu, Honggang; Zou, Yan; Zhao, Qingjie; Dan, Zhigang; Zhang, Dazhi; Wu, Qiuye published the article 《Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols》 about this compound( cas:57825-30-6 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: triazolyl difluorophenyl aralkylamino propanol preparation antifungal activity computational chem. Let’s learn more about this compound (cas:57825-30-6).

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, e.g., I, as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

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Electric Literature of C9H11Br. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of stereospecific cytotoxicity of (8R,8’R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring. Author is Yamauchi, Satoshi; Nishimoto, Asuka; Nishiwaki, Hisashi; Nishi, Kosuke; Sugahara, Takuya.

One of the arctigenin stereoisomers, (8R,8’R)-trans-form 1, showed stereospecific cytotoxicity against insect cells, Sf9 and NIAS-AeAl-2 cells. By the comparison with other stereoisomers, the most importance of the 8’R stereochem. for the higher activities was clarified. On the other hand, the wider range of activity level among stereoisomers against cancer cells, HL-60, was not observed The structure-activity relationship research using derivatives bearing (8R,8’R)-trans-form was performed to show the same level of activities of 3-iodo, 4-iodo, and 3,4-methylenedioxy derivatives 28, 29, and 36 as (8R,8’R)-trans-arctigenin 1. In the examination of thiono derivatives, 4-iodo thiono and 3,4-methylenedioxy thiono derivatives 66, 67 showed similar level of activities to that of (8R,8’R)-trans-arctigenin 1. The expression of ribosomal 28S rRNA gene of Sf9 cells was increased by (8R,8’R)-trans-arctigenin 1, whereas a degradation of DNA was not observed

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Formula: C9H11Br. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about A one-pot procedure for the synthesis of aromatic aldehydes in a heterogeneous medium. Author is Bratulescu, George.

Aromatic aldehydes were obtained from halogenated compounds and DMSO in solvent free medium. The method involves a Kornblum’s oxidation of organic halide in mild conditions using microwaves. An inorganic base such as solid potassium bicarbonate is used. The procedure is a smooth alternative to obtain aromatic aldehydes in heterogeneous medium. The important benefits of the method are also the absence of catalysts, the low time, and the good yield of the synthesis.

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Khurana, Jitender M.; Maikap, Golak C. published the article 《Bromomethylation of aromatics mediated by low frequency ultrasound》. Keywords: ultrasound aromatic bromomethylation.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Product Details of 57825-30-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.

Bromomethylation of aromatics mediated by low frequency ultrasound yielded bromomethylated aromatic rings which are useful synthetic intermediates. E.g., PhMe was bromomethylated with paraformaldehyde, 48% aqueous HBr and glacial HOAc on exposure to ultrasound to give 90% 4-methylbenzyl bromide. Among the 7 other compounds similarly prepared were 93% 2,5-dimethylbenzyl bromide, 93% 4-ethylbenzyl bromide, 92% 1-bromomethylnaphthalene and 95% 1-bromomethyl-2-methylnaphthalene.

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