Category: 62163-09-1

On October 18, 1988, Kato, Shozo; Ishizaki, Masahiko; Osada, Seiji published a patent.Recommanded Product: 62163-09-1 The title of the patent was Preparation of halogenated heterocydes as intermediates for agrochemicals and drugs. And the patent contained the following:

Polyhalogenated heterocycles are dehalogenated in H2O and/or alcs. in the presence of Fe powder and inorganic bases to give halogenated heterocycles. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Recommanded Product: 62163-09-1

The Article related to halogenated heterocycle intermediate drug agrochem, dehalogenation polyhaloheterocycle, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Recommanded Product: 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On January 31, 1981, Poradowska, Henryka; Kaniewska, Alicja published an article.Formula: C8H5ClN2 The title of the article was The mass spectra of halo derivatives of quinoxaline. And the article contained the following:

The mass spectra of 17 haloquinoxalines I (R-R3 = H, Br, Cl, Me) were recorded. All I gave mol.-ion peaks with typical isotopic ratios. The fragmentation path depended on the position of the halo atom: pyrazine-bound halo derivatives fragmented primarily via elimination of a halogen radical with insignificant cyanogen halide elimination, whereas benzene-bound halo derivatives fragmented via successive elimination of 2 RCN mols. (R = H, Me). The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Formula: C8H5ClN2

The Article related to haloquinoxaline mass spectra, quinoxaline halo mass spectra, methylquinoxaline halo mass spectra, Physical Organic Chemistry: Spectral and Related Studies and other aspects.Formula: C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On December 29, 2020, Xiong, Yunkui; Wang, Tao; Zhang, Yu; Qi, Liping published a patent.Application of 62163-09-1 The title of the patent was Phosphorus-containing quinoxaline compounds, its preparation method and application. And the patent contained the following:

A phosphorus-containing quinoxaline compounds, its preparation method and application having economical, easy operation, high yield, and suitable for large-scale production is provided. The phosphorus-containing quinoxaline compounds having following structure shown in formula I or formula II. The preparation method of phosphorus-containing quinoxaline compounds comprises the following steps: under the condition of participation of peroxide, mixing quinoxaline compound and diphenylphosphonium oxide compound react to obtain phosphorus-containing quinoxaline compound The application of phosphorus-containing quinoxaline compound was used to prepare medicines, optoelectronic materials, flame retardant materials or as phosphine ligands. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

The Article related to quinoxaline phosphine oxide preparation, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On January 28, 2021, Pan, Shiow-Lin; Yang, Chia-Ron; Huang, Han-Li; Tu, Huang-Ju; Liou, Jing-Ping; Teng, Che-Ming published a patent.Electric Literature of 62163-09-1 The title of the patent was Preparation of hydroxamic acid compounds as histone deacetylase 6 inhibitors and method for treating neuropathic pain. And the patent contained the following:

Disclosed herein are hydroxamic acid compounds of formula I. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6. Compounds of formula I wherein A is absent and CR1R2; E is absent and CR3R4; W is bicyclic aryl and bicyclic heteroaryl; X is CR5R6, O, S and NH and derivatives; Y is arylene and heteroarylene; Z is a bond, methylene and ethylene; R1, R2, R3 and R4 are independently H, halo, CN, amino, OH, etc.; R5 and R6 are independently H, (un)substituted C1-5 alkyl, (un)substituted C1-5 alkenyl, (un)substituted aryl, etc.; are claimed. Example compound II was prepared by reductive amination of Me 4-formylbenzoate with 3-quinolinamine followed by amidation with hydroxylamine hydrochloride. The invention compounds were evaluated for their HDAC6 inhibitory activity.y. From the assay, it was determined that compound II exhibited IC50 values of 19.11 nM and 0.78μM towards HDAC6 and HDAC1, resp. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Electric Literature of 62163-09-1

The Article related to hydroxamic acid preparation hdac6 inhibitor treatment neuropathic pain, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Electric Literature of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Poradowska, Henryka; Grzechowska, Alicja published an article in 1980, the title of the article was The investigations on synthesis and properties of halogenoquinoxalines.Application of 62163-09-1 And the article contains the following content:

Haloquinoxalines I and II (R = Cl, Br; R1, R2 = H, Me) were obtained in 10-34% yield by diazotization and halogenation of I and II (R = NH2), prepared by cyclizing phenylenetriamines with R1COCOR2. Spectra of I and II are discussed. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

The Article related to haloquinoxaline, quinoxaline halo, spectra haloquinoxaline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On March 31, 1984, McNab, Hamish published an article.Electric Literature of 62163-09-1 The title of the article was The thermolysis of polyazapentadienes. Part 4. Formation of indoles and quinoxalines from 5-(2,6-disubstituted phenyl)-1,2,5-triazapentadienes and related compounds. And the article contained the following:

7-Methylindole and 5-substituted quinoxalines are the main cyclized products from the gas-phase thermolysis of PhNHN:CRCH:NC6H3Me2-2,6 (R = H, Me) and MeON:CHCMe:NC6H3Me2-2,6. Both heterocyclic systems arise by competitive decomposition of a spirodienyl radical intermediate, the indole by loss of MeCN and an H atom, and the quinoxalines by loss of Me•. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Electric Literature of 62163-09-1

The Article related to pyrolysis cyclization aryltriazapentadiene mechanism, triazapentadiene aryl pyrolysis cyclization mechanism, quinoxaline, methylindole, indole methyl, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Electric Literature of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On August 9, 2012, Lankau, Hans-Joachim; Langen, Barbara; Grunwald, Christian; Hoefgen, Norbert; Stange, Hans; Dost, Rita; Egerland, Ute published a patent.Recommanded Product: 62163-09-1 The title of the patent was Preparation of (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases for treating CNS disorders and other diseases. And the patent contained the following:

The invention relates to (1,2,4)triazolo[4,3-a]quinoxaline derivatives of Formula I (wherein R1 is Ph, 2-pyridyl, 3-pyridyl or 4-pyridyl, all optionally substituted; R2 is H or (un)substituted C1-4 alkyl; R3, R4, R5 and R6 are independently H, halo, (un)substituted C1-4 alkyl, etc.) that are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases. Synthetic procedures for preparing I are exemplified. Example compound II was prepared in a 5-step synthesis that culminates in cyclization of intermediate 2-chlorobenzoic acid N’-(7-chloro-3-methylquinoxalin-2-yl)hydrazide. In assays measuring inhibition of recombinant PDE10A and PDE2A (expressed in baculovirus/SF21 cells), II had IC50 values of 0.045 and 0.003 μM, resp. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Recommanded Product: 62163-09-1

The Article related to triazoloquinoxaline derivative preparation inhibitor phosphodiesterase treatment cns disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On August 31, 1982, McNab, Hamish published an article.Synthetic Route of 62163-09-1 The title of the article was The thermolysis of polyazapentadienes. Part 2. Formation of quinoxalines from 5-aryl-1-phenyl-1,2,5-triazapentadienes. And the article contained the following:

Gas phase pyrolysis of RC6H4N:CHCH:NNHPh (I; R = p-Me, -OMe, -Cl, -Ac) at 600° and 10-2 Torr gave the quinoxalines II (R = Me, OMe, Cl, Ac, R1 = H) in 13-42% yield. Similarly, I (R = o-Me, -OMe, -Cl) gave II (R = H, R1 = Me, OMe, Cl) but in lower yields; II (R = R1 = H) was the major by-product due to ipso attack and elimination of the substituent. Meta-substituted I gave mixtures of 5- and 6-substituted quinoxalines on pyrolysis. The 5-isomer is dominant for compounds with meta-alkyl substituents whereas the 6-isomer is the major product for those with electron-withdrawing or -donating meta-substituents. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Synthetic Route of 62163-09-1

The Article related to pyrolysis cyclization aryltriazapentadiene regiochem, triazapentadiene aryl pyrolysis cyclization, quinoxaline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Synthetic Route of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On August 31, 1986, Nasielski-Hinkens, R.; Vande Vyver, E.; Nasielski, J. published an article.Related Products of 62163-09-1 The title of the article was Regioselectivity in the reaction of nitroquinoxaline N-oxides with phosphoryl chloride. And the article contained the following:

Oxidation of nitroquinoxalines I (n = 0; R, R1 = H, Me) by m-ClC6H4CO2OH gave their N-oxides; the NO2 group orients the O atom preferentially to N-1, but the N-4:N-1 selectivity is diminished in the methylated derivatives Meisenheimer reaction of I (n = 1, R = R1 = H) with POCl3 gave I (n = 0, R = Cl, R1 = H). The orientation of the entering Cl is discussed on the basis of electronic effects induced by the N-oxide and NO2 groups. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Related Products of 62163-09-1

The Article related to nitroquinoxaline oxide phosphoryl chloride regiochem, chloroquinoxaline, quinoxaline chloro, meisenheimer nitroquinoxaline oxide regiochem, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 1, 2013, Troian-Gautier, Ludovic; De Winter, Julien; Gerbaux, Pascal; Moucheron, Cecile published an article.Formula: C8H5ClN2 The title of the article was A Direct Method for Oxidizing Quinoxaline, Tetraazaphenanthrene, and Hexaazatriphenylene Moieties Using Hypervalent λ3-Iodinane Compounds. And the article contained the following:

An efficient oxidation reaction of various electron-poor quinoxaline-core-containing compounds, such as quinoxalines, 1,4,5,8-tetraazaphenanthrenes, and 1,4,5,8,9,12-hexaazatriphenylene, using [bis(trifluoroacetoxy)iodo]benzene is reported. These compounds are converted into the corresponding quinoxalinediones in good to high yields at room temperature using an acetonitrile/water solvent mixture This unprecedented reaction should enable the synthesis of a wide variety of compounds useful in several fields of chem. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Formula: C8H5ClN2

The Article related to quinoxaline tetraazaphenanthrene hexaazatriphenylene hypervalent iodinane oxidation, quinoxalinedione derivative preparation trifluoroacetoxyiodobenzene, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider