Category: 6298-37-9

6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, c. N-(Quinoxalin-6-yl)acetamide A solution of quinoxalin-6-amine (14.0 g, 0.97 mol) in acetic anhydride (120 mL) was stirred at 100 C. for 1 h. Excess acetic anhydride was removed under reduced pressure. To the residue was added 150 mL of saturated aqueous sodium bicarbonate solution. The mixture was extracted with DCM (3*150 mL), and the combined organic layers were dried over sodium sulfate and concentrated under reduce pressure to give N-(quinoxalin-6-yl)acetamide as a yellow solid (8.4 g, yield 47%). ESI MS: m/z 188.1 [M+H]+.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sunovion Pharmaceuticals Inc.; US2012/178748; (2012); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, 1H-indole-6-amine (116.3 mg, 0.88 mmol), final product 03 (94.5 mg, 0.29 mmol) and triethylamine (95.4 mg, 0.94 mmol) were added to a round bottom flask, and 2 mL of DMF was dissolved.Heat to 50 C and stir overnight.At the end of the reaction, 2 mL of water was added, acidified with trifluoroacetic acid, and purified by HPLC to obtain 87.4 mg of a yellow oil

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0269] A 20 mL vial was charged with picolinic acid (244 mg, 1.981 mmol), quinoxalin-6- amine (250 mg, 1.722 mmol), HATU (851 mg, 2.239 mmol), DMF (6 mL) and Et3N (0.720 mL, 5.17 mmol). The reaction mixture was stirred at 70C for 3 hours, then water was added and a precipitate was formed. The precipitate was isolated by filtration, washed with water, and dried under vacuum overnight to give the title compound. NMR (400 MHz, CD.iCN) delta ppm 7.65 (ddd,.7=7.64, 4.74, 1.26 Hz, 1H), 8.05 (td, J=7.71, 1.77 Hz, 1H), 8,08 – 8.12 (m, 1H), 8.15 – 8.20 (m, 1H), 8.29 (dt,,7=7,83, 1.01Hz, 1H), 8,69 (d, J=2.27 Hz, 1H), 8.74 (d, J=4.84 Hz, 1

6298-37-9, As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GREEN, Jason; HOPKINS, Maria; JONES, Benjamin; KIRYANOV, Andre A.; KUEHLER, Jon; MONENSCHEIN, Holger; MURPHY, Sean; NIXEY, Thomas; SUN, Huikai; (300 pag.)WO2018/183145; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

Step A diethyl N-(6-quinoxalyl)aminomethylenemalonate A mixture of 6-aminoquinoxaline(19.2 g) and diethyl ethoxymethylenemalonate(34.8 g) was heated for an hour at 110 C. After filtration, the crystals thus obtained were crystallized from ethanol to give diethyl N-(6-quinoxalyl)aminomethylenemalonate (37.5 g) as pale yellow needles, m.p. 112-114 C., 6298-37-9

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Taisho Pharmaceutical Co., Ltd.; US4190581; (1980); A;,
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6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

Synthesis of 4-((quinoxalin-6-ylamino)methyl)-1H-pyrazole-5-carboxylic acid (5-B) To a suspension of product (4-B) (100 mg, 0.71 mmol) and quinoxalin-6-amine (104 mg, 0.71 mmol) in a solution of 1,2-dichloroethane (DCE, 5 mL) and DMF (5 mL) was added acetic acid (5 drops) at rt. The reaction mixture was then stuffed for 16 h. MeOH (5 mL) was added, followed by NaBH4 (100 mg, 2.63 mmol). The reaction mixture was stuffed at rt for another 30 mm.The solution was diluted with ethyl acetate (30 mL); washed with 5 % citric acid (10 mL) and brine (20 mL); dried over Na2504 and concentrated to give crude product (5-B) (200 mg, 99 %) as a yellow solid. LC-MS (M+H) = 270.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; X-RX, INC.; KEEFE, Anthony, D.; WAGNER, Richard, W.; CLARK, Matthew; ZHANG, Ying; GIKUNJU, Diana; CUOZZO, John; THOMSON, Heather; WO2013/106414; (2013); A1;,
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6298-37-9,6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluorophenyl)propanoic acid (500 mg, 1.66 mmol) and quinoxalin-6-amine (219 mg, 1.5 mmol) in DMF (7 mL), DIPEA (0.80 mL, 4.5 mmol) was added, followed by HATU (631 mg, 1.66 mmol) and then the reaction mixture was stirred at rt for 16 h. The reaction mixture was partitioned between aq. NaHCCb-NaCl (10 mL) and EtOAc (3 x 25 mL), and the combined organic components were dried (Na2S04), filtered, concentrated and then purified by flash silica chromatography (24 g Silica, eluted with solv A = Hexane / solv B = EtOAc, gradient from 0 – 50%B, hold at 50%B) to afford the title compound (515 mg). LC-MS retention time = 1.15 min; m/z = 429.0 [M+H]+. (Column: Waters Aquity BEH C18 2.1 x 50 mm 1.7U. Solvent A = 100% Water: 0.05% TFA. Solvent B = 100% Acetonitrile: 0.05% TFA. Flow Rate = 0.8 mL/min. Gradient: 2-98% B. Gradient Time = 1.5 min. Wavelength = 220). NMR (400 MHZ, chloroform-d) delta 8.96 – 8.65 (m, 3H), 8.31 (d, J=2.3 Hz, IH), 8.01 (d, J=9.0 Hz, IH), 7.81 (dd, J=9.0, 2.3 Hz, IH), 6.83 (d, J=6.0 Hz, 2H), 6.77 – 6.66 (m, IH), 5.19 (d, J=6.8 Hz, IH), 4.58 (d, J=6.3 Hz, IH), 3.30 (dd, J=14.1, 6.5 Hz, IH), 3.20 – 3.05 (m, IH), 1.46 (s, 9H).

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VIIV HEALTHCARE (No.5) LIMITED; BENDER, John A.; LOPEZ, Omar D.; NGUYEN, Van N.; YANG, Zhong; WANG, Alan Xiangdong; WANG, Gan; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; THANGATHIRUPATHY, Srinivasan; (350 pag.)WO2016/172425; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.,6298-37-9

To a solution of 6-aminoquinoxaline (290 mg, 2 mmol) and hydroxypentadecanoic acid (518 mg, 2 mmol) in dichloromethane (40 ml) are added triethylamine (0.83 ml, 6 mmol), EDC (768 mg, 4 mmol) and HOBt (405 mg, 3 mmol). The mixture is stirred overnight at room temperature under inert atmosphere of nitrogen. The reaction is hydrolyzed, extracted with dichloromethane and then washed with a concentrated NH4Cl solution. The organic phase is dried on anhydrous MgSO4 and concentrated under reduced pressure. The residue obtained is then dissolved in DMF (10 ml), and then imidazole (136 mg, 2 mmol) and TBDMS-Cl (332 mg, 2.2 mmol) are added. The mixture is stirred overnight at room temperature under inert atmosphere of nitrogen. The reaction is hydrolyzed and then extracted with ethyl acetate, dried on anhydrous MgSO4 and concentrated under vacuum. The silylated product is purified on a silica column in a mixture of cyclohexane and ethyl acetate in a proportion of 8:2. The product is then dissolved in THF (10 ml) and TBAF (3 ml, 1 M in THF) is added. After 5 minutes the reaction is hydrolyzed and extracted with ethyl acetate. The organic phase is dried on anhydrous MgSO4 and concentrated under vacuum. The product is obtained with a total yield of 38% on three steps.

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); US2011/118270; (2011); A1;,
Quinoxaline – Wikipedia
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, Example 305: Preparation of N4-cyclopropyl-N2-(quinoxalin-6-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine2-Chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine (0.060 g, 0.253 mmol) and quinoxalin-6-amine (0.037 g, 0.253 mmol) were mixed in acetic acid (1 ml). The mixture was microwaved at 120 C for 20 min and then concentrated. 17 mg of product was recovered after automated reverse phase chromatography (water-MeCN). MS calcd for [Ci6Hi3F3N6+H]+:347.13, found 347.10.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; YALE UNIVERSITY; SHAW, Reuben J.; EGAN, Daniel F.; COSFORD, Nicholas; TURK, Benjamin; VAMOS, Mitchell; PANICKAR, Dhanya Raveendra; CHUN, Matthew; SHEFFLER, Doug; (315 pag.)WO2016/33100; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of an a-halogenoketone, an amine and a base (DIPEA or triethylamine) in a solvent (e.g. DMF, ethanol, acetonitrile, dioxane or THF) was irradiated in a microwave oven at 100C to 200C (more in particular at 120 to 200 C) for 5 to 180 min. (more in particular for 15 to 120 min). The reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Amino-5-bromoquinoxaline hydrobromide 6-Aminoquinoxaline (2.08 g, 14.4 mmol) was dissolved in 11.5 ml glacial acetic acid. The solution was cooled in water-while a solution of bromine (0.74 ml, 2.3 g, 14.4 mmol) in 1.5 ml glacial acetic acid was added slowly over 15 min. After stirring for an additional 30 min, the orange red solid formed was filtered off and washed thoroughly with dry ether. The solid was dried in vacuo overnight to yield 4.44 g crude product (a yield of 100%). The compound, 6-amino-5-bromoquinoxaline hydrobromide, had no definite melting point. A phase change (from fine powder to red crystals) was noticed at about 220 C. Decomposition was observed at about 245 C. It was used directly for the next step., 6298-37-9

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Allergan, Inc.; US5373010; (1994); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider