Thiono and dithio esters. 17. Reaction of dithionoxalic esters with amines was written by Hoppe, H.;Hartke, Klaus. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1975.Electric Literature of C10H10N2O2 This article mentions the following:
ROC(S)C(S)OR (I, R = Me, Et) reacted with primary amines to give R1R2NC(S)C(S)NR1R2 (II, R1 and R2 = H, alkyl, aryl). In dilute alc. solution ROC(:NR1)C(S)OR and ROC(:NR1)C(:NR1)OR were obtained. Reaction of I with secondary amines gave ROC(S)C(S)NR1R2 (III) intermediate to II. III was substituted by primary amines to give R3NHC(S)C(S)NR1R2. On heating in base III rearranged to RSC(O)C(S)NR1R2, which reacted with primary amines to give R3NHC(O)C(S)NR1R2. Reaction of I with o-H2NC6H4XH (X = O, S) gave bibenzazolyls IV (R4 = H, Cl). With o-(H2N)2C6H4 quinoxalines V were obtained. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxyquinoxaline (cas: 6333-43-3Electric Literature of C10H10N2O2).
2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Electric Literature of C10H10N2O2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider